Elizabeth B Doherty

US Patent:

6977264, Dec 20, 2005

Filed:

Jul 24, 2002

Appl. No.:

10/205649

Inventors:

Christopher H. Fotsch - Thousand Oaks CA, US
Michael Croghan - Thousand Oaks CA, US
Elizabeth M. Doherty - Newbury Park CA, US
Michael G. Kelly - South San Francisco CA, US
Mark H. Norman - Thousand Oaks CA, US
Duncan M. Smith - Thousand Oaks CA, US
Nuria Tamayo - Newbury Park CA, US
Ning Xi - Thousand Oaks CA, US
Shimin Xu - Ventura CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D211/06
A61K031/445

US Classification:

514330, 546226

Abstract:

Selected substituted piperidine compounds are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

US Patent:

7053088, May 30, 2006

Filed:

May 20, 2003

Appl. No.:

10/445170

Inventors:

Elizabeth M. Doherty - Newbury Park CA, US
Jiawang Zhu - Simi Valley CA, US
Markian Stec - Fillmore CA, US
Mark H. Norman - Thousand Oaks CA, US
Vassil I. Ognyanov - Thousand Oaks CA, US
Christopher H. Fotsch - Thousand Oaks CA, US
Ning Chen - Thousand Oaks CA, US
Partha P. Chakrabarti - Simi Valley CA, US
Liping H. Pettus - Thousand Oaks CA, US
Hui-Ling Wang - Thousand Oaks CA, US
Xianghong Wang - Moorpark CA, US
Premilla Arasasingham - Thousand Oaks CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 31/50

US Classification:

514247, 514367, 544242, 544284, 548152

Abstract:

Compounds having the general structure.

US Patent:

7144888, Dec 5, 2006

Filed:

Aug 8, 2003

Appl. No.:

10/638009

Inventors:

Elizabeth M. Doherty - Newbury Park CA, US
Jiawang Zhu - Simi Valley CA, US
Markian Stec - Fillmore CA, US
Mark H. Norman - Thousand Oaks CA, US
Hui-Ling Wang - Thousand Oaks CA, US
Christopher H. Fotsch - Thousand Oaks CA, US
Ning Chen - Thousand Oaks CA, US
Partha P. Chakrabarti - Simi Valley CA, US
Celia Dominguez - Thousand Oaks CA, US
James Richard Falsey - Westlake Village CA, US
Christopher Hulme - Simi Valley CA, US
Jodie Katon - Ventura CA, US
Thomas Nixey - Newbury Park CA, US
Vassil I. Ognyanov - Thousand Oaks CA, US
Liping H. Pettus - Thousand Oaks CA, US
Robert Michael Rzasa - Ventura CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 239/34
C07D 239/38
C07D 401/12
C07D 403/12
C07D 405/12
C07D 409/12
C07D 417/12
A61K 31/505
A61K 31/506
A61K 31/4427
A61P 19/02
A61P 25/06

US Classification:

514269, 544319, 544315, 544323

Abstract:

Compounds having the general structure.

US Patent:

7148221, Dec 12, 2006

Filed:

Aug 1, 2005

Appl. No.:

11/195134

Inventors:

Elizabeth M. Doherty - Newbury Park CA, US
Jiawang Zhu - Simi Valley CA, US
Markian Stec - Fillmore CA, US
Mark H. Norman - Thousand Oaks CA, US
Hui-Ling Wang - Thousand Oaks CA, US
Christopher H. Fotsch - Thousand Oaks CA, US
Ning Chen - Thousand Oaks CA, US
Partha P. Chakrabarti - Simi Valley CA, US
Celia Dominguez - Thousand Oaks CA, US
James Richard Falsey - Westlake Village CA, US
Christopher Hulme - Simi Valley CA, US
Jodie Katon - Ventura CA, US
Thomas Nixey - Newbury Park CA, US
Vassil I. Ognyanov - Thousand Oaks CA, US
Liping H. Pettus - Thousand Oaks CA, US
Robert Michael Rzasa - Ventura CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 237/14
C07D 237/18
C07D 223/16
C07D 223/18
A61K 31/501
A61P 25/06

US Classification:

514247, 51425201, 514183, 51421703, 51422202, 5142268, 5142278, 5142288, 5142315, 514214, 514242, 514245, 544238, 544239, 544179, 544180, 540484, 540596

Abstract:

Compounds having the general structure.

US Patent:

7265138, Sep 4, 2007

Filed:

Feb 9, 2004

Appl. No.:

10/775980

Inventors:

Elizabeth M. Doherty - Newbury Park CA, US
Christopher H. Fotsch - Thousand Oaks CA, US
Nianhe Han - Thousand Oaks CA, US
Randall W. Hungate - Camarillo CA, US
Qingyian Liu - Camarillo CA, US
Mark H. Norman - Thousand Oaks CA, US
Ning Xi - Thousand Oaks CA, US
Shimin Xu - Thousand Oaks CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 31/425
C07D 277/04

US Classification:

514365, 514374, 514396, 548146, 548215, 5483001

Abstract:

Compounds having the general structure.

US Patent:

7332511, Feb 19, 2008

Filed:

Aug 1, 2005

Appl. No.:

11/195159

Inventors:

Elizabeth M. Doherty - Newbury Park CA, US
Jiawang Zhu - Simi Valley CA, US
Markian Stec - Fillmore CA, US
Mark H. Norman - Thousand Oaks CA, US
Hui-Ling Wang - Thousand Oaks CA, US
Christopher H. Fotsch - Thousand Oaks CA, US
Ning Chen - Thousand Oaks CA, US
Partha P. Chakrabarti - Simi Valley CA, US
Celia Dominguez - Thousand Oaks CA, US
James Richard Falsey - Westlake Village CA, US
Christopher Hulme - Simi Valley CA, US
Jodie Katon - Ventura CA, US
Thomas Nixey - Newbury Park CA, US
Vassil I. Ognyanov - Thousand Oaks CA, US
Liping H. Pettus - Thousand Oaks CA, US
Robert Michael Rzasa - Ventura CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 213/30
C07D 213/32
C07D 401/12
C07D 401/14
C07D 403/12
C07D 403/14
A61K 31/4427
A61P 19/02
A61P 35/00

US Classification:

514345, 5462681, 544 8, 544 53, 544 56, 544 59, 544 63, 544 67, 544 88, 544106, 544238, 544242, 544338, 540450, 540484

Abstract:

Compounds having the general structure.

US Patent:

7396831, Jul 8, 2008

Filed:

Aug 1, 2005

Appl. No.:

11/195303

Inventors:

Elizabeth M. Doherty - Newbury Park CA, US
Jiawang Zhu - Simi Valley CA, US
Markian Stec - Fillmore CA, US
Mark H. Norman - Thousand Oaks CA, US
Vassil I. Ognyanov - Thousand Oaks CA, US
Christopher H. Fotsch - Thousand Oaks CA, US
Ning Chen - Thousand Oaks CA, US
Partha P. Chakrabarti - Simi Valley CA, US
Liping H. Pettus - Thousand Oaks CA, US
Hui-Ling Wang - Thousand Oaks CA, US
Xianghong Wang - Moorpark CA, US
Premilla Arasasingham - Thousand Oaks CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 403/12
C07D 403/14
A61K 31/501

US Classification:

514247, 544224, 544238, 51425201, 51425202, 51425203, 51425205

Abstract:

Compounds having the general structure.

US Patent:

7511044, Mar 31, 2009

Filed:

Feb 11, 2005

Appl. No.:

11/056568

Inventors:

Hui-Ling Wang - Thousand Oaks CA, US
Chenera Balan - Thousand Oaks CA, US
Elizabeth M. Doherty - Newbury Park CA, US
James R. Falsey - Moorpark CA, US
Vijay Keshav Gore - Thousand Oaks CA, US
Jodie Katon - Ventura CA, US
Mark H. Norman - Thousand Oaks CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 403/04
A61K 31/496

US Classification:

51425214, 51425218, 51425219, 5142522, 544295

Abstract:

Pyrimidine ethers and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.