Ttoadvisors 2006 - 2008
Managing Director
Wisconsin Alumni Research Foundation Jul 1998 - Oct 2006
General Counsel and Director of Business Development
Stemina Biomarker Discovery Neuropointdx Jul 1998 - Oct 2006
Chief Executive Officer
Stemina Biomarker Discovery, Inc. Jul 1998 - Oct 2006
Chief Executive Officer
Quarles & Brady Llp Aug 1994 - Jul 1998
Associate
Education:
University of Wisconsin - Madison 2000 - 2004
Master of Science, Masters
University of Wisconsin Law School 1991 - 1994
Doctor of Jurisprudence, Doctorates, Law
University of Wisconsin - Whitewater 1989 - 1993
Master of Business Administration, Masters, Finance
University of Wisconsin - Madison 1987
Edgewood High School
Miami University
Skills:
Licensing Biotechnology Intellectual Property Life Sciences Technology Transfer Lifesciences Commercialization Pharmaceutical Industry Start Ups Drug Discovery Protein Chemistry Venture Capital Genomics Entrepreneurship Biochemistry Strategy Patents Biopharmaceuticals Molecular Biology Drug Development Cell Cancer Clinical Trials Cro Bioinformatics R&D Glp Cell Culture Immunology Chemistry Clinical Development Validation Medical Devices Science Infectious Diseases Fda Vaccines Oncology Analytical Chemistry Regulatory Affairs Hplc Cell Biology Strategic Planning Management Leadership Business Development Research Business Strategy Research and Development
Stemina Biomarker Discovery since Oct 2006
CEO
TTOAdvisors 2006 - 2008
Managing Director
Wisconsin Alumni Research Foundation Jul 1998 - Oct 2006
General Counsel and Director of Business Development
US Bank 1988 - 1992
Commercial Lender
Education:
University of Wisconsin-Madison 2000 - 2004
MS, Bacteriology
University of Wisconsin Law School 1991 - 1994
JD, Law
University of Wisconsin-Whitewater 1989 - 1993
MBA, Finance
Miami University
Skills:
Licensing Biotechnology Intellectual Property Life Sciences Technology Transfer Lifesciences Commercialization
Paul R. WEST - Arena WI, US Alan M. SMITH - Madison WI, US Elizabeth L.R. DONLEY - Madison WI, US Gabriela G. CEZAR - Madison WI, US
Assignee:
Stemina Biomarker Discovery, Inc. - Madison WI
International Classification:
C12Q 1/18
US Classification:
435 32
Abstract:
The invention provides biomarker profiles of metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human stem-like cells (hSLCs) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic effects of such chemical compounds. Specifically, a more predictive developmental toxicity model, based on an in vitro method that utilizes both hSLCs and metabolomics to discover biomarkers of developmental toxicity is disclosed.
Diagnosis And Treatment Of Autism Spectrum Disorders Based On Amine Containing Metabotypes
- Madison WI, US Joseph King - Madison WI, US Paul R. West - Arena WI, US Michael Ludwig - Middleton WI, US Elizabeth L.R. Donley - Madison WI, US Robert Burrier - Verona WI, US
International Classification:
G01N 33/68
Abstract:
The invention provides methods of diagnosing autism spectrum disorders (ASD) by analyzing ratios of concentrations of selected amine containing compounds in a sample, such as a blood sample, from a subject. Based on the discovery that specific amine containing compounds and their ratios are dysregulated in patients with ASD, these metabotypes or subtypes of metabolism have the potential to diagnose earlier and suggest more precise treatment based on the metabolism of the individual. The invention provides methods of analyzing amine containing compounds and ratios in a test subject and determining whether the test subject has or is at risk of developing an ASD by comparing ratios from the test subject to ratios from subjects diagnosed with a neurodevelopmental disorder such as ASD who share a common profile of metabolism which is not found in the majority of typically developing subjects. The invention also provides methods of determining a course of treatment for an individual that has or is at risk of developing an ASD based on the individuals metabotype.
Paul West - Arena WI, US Robert Burrier - Verona WI, US Joseph King - Madison WI, US Roxana Alexandridis - Madison WI, US Laura Egnash - Deforest WI, US Elizabeth L.R. Donley - Madison WI, US Michael Ludwig - Middleton WI, US
Assignee:
Stemina Biomarker Discovery, Inc. - Madison WI
International Classification:
G01N 33/68 G01N 30/72
Abstract:
With the present invention, metabolomics biomarkers are used to identify subtypes within the autism spectrum disorder (ASD) population. In one embodiment, levels of the metabolite 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) of about six times or greater than the median level in typically developing (TD) individuals or about 2 μM or greater place the individual in an autism subpopulation that includes less than 20% of the total ASD population. Thus, CMPF is a biomarker able to discriminate a subtype of ASD.
Predicting Human Developmental Toxicity Of Pharmaceuticals Using Human Stem-Like Cells And Metabolomics
- Madison WI, US Alan M. Smith - Madison WI, US Elizabeth L.R. Donley - Madison WI, US Gabriela G. Cezar - Madison WI, US
Assignee:
STEMINA BIOMARKER DISCOVERY, INC. - Madison WI
International Classification:
G01N 33/50
US Classification:
435 29
Abstract:
The invention provides biomarker profiles of metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human stem-like cells (hSLCs) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic effects of such chemical compounds. Specifically, a more predictive developmental toxicity model, based on an in vitro method that utilizes both hSLCs and metabolomics to discover biomarkers of developmental toxicity is disclosed.
Name / Title
Company / Classification
Phones & Addresses
Elizabeth Donley Director
M3 INSURANCE SOLUTIONS, INC
3113 W Beltline Hwy, Madison, WI 53713 9201 Bear Claw Way, Madison, WI 53717
Elizabeth L. Donley Chief Executive Officer
Stemina Biomarker Discovery, Inc. Biotechnology · Biotechnology Company
504 S Rosa Rd SUITE 150, Madison, WI 53719 6082040104, 6082040107