Christopher John Love - Hampshire, GB Joseph Elisabeth Leenaerts - Rijkevorsel, BE Ludwig Paul Cooymans - Beerse, BE Donald Alec Lebsack - San Diego CA, US Bryan James Branstetter - Oceanside CA, US Jason Christopher Rech - San Diego CA, US Elizabeth Ann Gleason - La Mesa CA, US Jennifer Diane Venable - Solana Beach CA, US Danielle Wiener - La Jolla CA, US Deborah Margaret Smith - San Diego CA, US James Guy Breitenbucher - Escondido CA, US
Assignee:
Janssen Pharmaceutica NV - Beerse
International Classification:
C07D 215/38
US Classification:
546146, 546169
Abstract:
The present invention is related to novel compounds of formula (I) having P2X7 antagonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans. (I).
Carbon-Linked Tetrahydro-Pyrazolo-Pyridine Modulators Of Cathepsin S
Michael K. Ameriks - San Diego CA, US Frank U. Axe - Sutter Creek CA, US James P. Edwards - San Diego CA, US Cheryl A. Grice - Carlsbad CA, US Hui Cai - San Diego CA, US Elizabeth Ann Gleason - San Diego CA, US Steven P. Meduna - San Diego CA, US Kevin L. Tays - Cardiff by the Sea CA, US John J. M. Wiener - La Jolla CA, US Alvah T. Wickboldt - San Diego CA, US
Carbon-linked tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.