Elizabeth J Simpson

US Patent:

57504130, May 12, 1998

Filed:

May 4, 1995

Appl. No.:

8/433104

Inventors:

Marjorie A. Morrison - Grayslake IL
Steven E. Lunetta - Waukegan IL
Victoria P. Meucci - Chicago IL
Mariola B. Zajac - Chicago IL
Elizabeth A. Simpson - Skokie IL

Assignee:

Abbott Laboratories

International Classification:

G01N 33536

US Classification:

436537

Abstract:

Cyclosporine derivatives useful as detectable tracer compounds for the immunoassay determination of cyclosporine are disclosed. The cyclosporine derivatives comprise a detectable moiety coupled to the amino acid at the first position (MeBmt) in cyclosporine, the second position (Abu) in cyclosporine, the third position (Sar) in cyclosporine, the eighth position (D-Ala) in cyclosporine, or the tenth position (MeLeu) in cyclosporine. A preferred cyclosporine derivative comprises a fluorescent moiety coupled to the hydroxyl group of the amino acid at the first position in cyclosporine, and is especially useful for the fluorescent polarization immunoassay determination of cyclosporine. A fluorescent polarization immunoassay method and test kit are also disclosed.

US Patent:

54896681, Feb 6, 1996

Filed:

Nov 4, 1993

Appl. No.:

8/148164

Inventors:

Marjorie A. Morrison - Grayslake IL
Steven E. Lunetta - Waukegan IL
Victoria P. Meucci - Chicago IL
Mariola B. Zajac - Chicago IL
Elizabeth A. Simpson - Skokie IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07K 764

US Classification:

530321

Abstract:

Cyclosporine derivatives useful as detectable tracer compounds for the immunoassay determination of cyclosporine are disclosed. The cyclosporine derivatives comprise a detectable moiety coupled to the amino acid at the first position (MeBmt) in cyclosporine, the second position (Abu) in cyclosporine, the third position (Sar) in cyclosporine, the eighth position (D-Ala) in cyclosporine, or the tenth position (MeLeu) in cyclosporine. A preferred cyclosporine derivative comprises a fluorescent moiety coupled to the hydroxyl group of the amino acid at the first position in cyclosporine, and is especially useful for the fluorescent polarization immunoassay deterimination of cyclosporine. A fluorescent polarization immunoassay method and test kit are also disclosed.

Address:

5538 Dunbar Rd, Crossville, TN 38572

Phone:

9317886599

VIN:

3GNCA53V99S523187

Make:

CHEVROLET

Model:

HHR

Year:

2009