Elizabeth H Stoner

US Patent:

6355649, Mar 12, 2002

Filed:

Oct 30, 2000

Appl. No.:

09/699906

Inventors:

Glenn J. Gormley - Westfield NJ
Keith D. Kaufman - Westfield NJ
Elizabeth Stoner - Westfield NJ
Joanne Waldstreicher - Scotch Plains NJ

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

A61K 3144

US Classification:

514284, 514864, 514880

Abstract:

The instant invention involves a method of treating and/or reversing androgenic alopecia and promoting hair growth, and methods of treating acne vulgaris, seborrhea, and female hirsutism, by administering to a patient in need of such treatment a 5-reductase 2 inhibitor, such as finasteride, in a dosage amount under 5 mgs/day.

US Patent:

6403640, Jun 11, 2002

Filed:

Aug 24, 2000

Appl. No.:

09/644998

Inventors:

Elizabeth Stoner - Westfield NJ
Joanne Waldstreicher - Scotch Plains NJ
Curtis J. Nickel - Elginburg, CA
Michel A. Pontari - Lafayette Hill PA

Assignee:

Merck Co., Inc. - Rahway NJ
Temple University of the Commonwealth of Higher Ed. - Philadelphia PA

International Classification:

A61K 3134

US Classification:

514473, 514152, 51425216, 514284, 514315, 514323

Abstract:

The use of a COX-2 selective inhibitor for the treatment of chronic prostatitis or chronic pelvic pain syndrome is disclosed.

US Patent:

6432971, Aug 13, 2002

Filed:

Jun 6, 2001

Appl. No.:

09/875381

Inventors:

Glenn J. Gormley - Westfield NJ
Elizabeth Stoner - Westfield NJ

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

A61K 3144

US Classification:

514284

Abstract:

17-N-monosubstituted-carbamoyl-4-aza-5-androst-1-en-3-ones of the formula wherein R is selected from hydrogen, methyl and ethyl and R is a straight or branched chain alkyl, cycloalkyl, aralkyl of from 1-12 carbons, or monocyclic aryl optionally containing 1 or more lower alkyl substituents of 1-2 carbon atoms and/or 1 or more halogens, and Râ, Râ, Rââ are hydrogen or methyl are useful for the prevention of prostatic carcinoma.

US Patent:

20020042425, Apr 11, 2002

Filed:

Dec 7, 2001

Appl. No.:

10/010678

Inventors:

Glenn Gormley - Westfield NJ, US
Keith Kaufman - Westfield NJ, US
Elizabeth Stoner - Westfield NJ, US
Joanne Waldstreicher - Scotch Plains NJ, US

International Classification:

A61K031/473
A61K007/06

US Classification:

514/290000, 424/070100

Abstract:

The instant invention involves a method of treating and/or reversing androgenic alopecia and promoting hair growth, and methods of treating acne vulgaris, seborrhea, and female hirsutism, by administering to a patient in need of such treatment a 5-reductase 2 inhibitor, such as finasteride, in a dosage amount under 5 mgs/day.

US Patent:

20030069264, Apr 10, 2003

Filed:

Sep 2, 1999

Appl. No.:

09/388658

Inventors:

ELIZABETH STONER - WESTFIELD NJ, US
DANIEL Z. WANG - EDISON NJ, US
JOANNE WALDSTREICHER - SCOTCH PLAINS NJ, US

International Classification:

A61K031/473
C07D221/18
G01N033/53

US Classification:

514/284000, 546/077000

Abstract:

This invention is concerned with a method of determining the risk of a urologic event, particularly an event selected from BPH-related surgery and acute urinary retention in a man by measuring the man's serum PSA level. The present invention also provides for a method of reducing the risk of the urologic event in a man determined to be at risk by the present urologic event risk-determining method by administration to the man of a compound which inhibits 5-reductase. Also provided is a kit for determining the risk of a urologic event.

US Patent:

60461837, Apr 4, 2000

Filed:

Feb 20, 1998

Appl. No.:

9/027105

Inventors:

Glenn J. Gormley - Westfield NJ
Elizabeth Stoner - Westfield NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 3156
A61K 3158
A61K 31505

US Classification:

514170

Abstract:

Disclosed is an improved treatment for men with benign prostatic hyperplasia (BPH), involving combination therapy of a 5. alpha. -reductase inhibitor, e. g. a 17. beta. -substituted 4-azasteroid, a 17. beta. -substituted non-azasteroid, 17. beta. -acyl-3-carboxy-androst-3,5-diene, benzoylaminophenoxybutanoic acid derivative, fused benz(thio)amide or cinnamoylamide derivative, aromatic 1,2-diethers or thioethers, aromatic ortho acylaminophenoxy alkanoic acids, ortho thioalkylacylaminophenoxy alkanoic acids, pharmaceutically acceptable salts and esters thereof, and particularly finasteride, in combination with an. alpha. sub. 1 -adrenergic receptor blocker, i. e. , terazosin. The combination provides therapy at the molecular level for the underlying cause of the disease as well as providing symptomatic relief. Pharmaceutical compositions useful for treatment are also disclosed.

US Patent:

56293186, May 13, 1997

Filed:

Jun 2, 1995

Appl. No.:

8/448451

Inventors:

Glenn J. Gormley - Westfield NJ
Elizabeth Stoner - Westfield NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 3144

US Classification:

514284

Abstract:

The present invention is concerned with the use of 17. beta. -N-monosubstituted-carbamaoyl-4-aza-5. alpha. -androst-1-en-3-one compounds as testosterone-5. alpha. -reductase inhibitors for the treatment of chronic prostatitis.

US Patent:

61748927, Jan 16, 2001

Filed:

Nov 24, 1999

Appl. No.:

9/448930

Inventors:

Glenn J. Gormley - Westfield NJ
Keith D. Kaufman - Westfield NJ
Elizabeth Stoner - Westfield NJ
Joanne Waldstreicher - Scotch Plains NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31435

US Classification:

514284

Abstract:

The instant invention involves a method of treating and/or reversing androgenic alopecia and promoting hair growth, and methods of treating acne vulgaris, seborrhea, and female hirsutism, by administering to a patient in need of such treatment a 5. alpha. -reductase 2 inhibitor, such as finasteride, in a dosage amount under 5 mgs/day.