Elizabeth F Wheeler

US Patent:

7081227, Jul 25, 2006

Filed:

Jun 7, 2004

Appl. No.:

10/862998

Inventors:

David S. Clague - Livermore CA, US
Elizabeth K. Wheeler - Livermore CA, US
Abraham P. Lee - Irvine CA, US

Assignee:

The Reagents of the University of California - Oakland CA

International Classification:

G01N 21/00

US Classification:

422 81, 422 82, 422 50, 422 681, 436518, 436524, 436 52, 435 71, 4352871

Abstract:

A flow cytometer includes a flow cell for detecting the sample, an oil phase in the flow cell, a water phase in the flow cell, an oil-water interface between the oil phase and the water phase, a detector for detecting the sample at the oil-water interface, and a hydrophobic unit operatively connected to the sample. The hydrophobic unit is attached to the sample. The sample and the hydrophobic unit are placed in an oil and water combination. The sample is detected at the interface between the oil phase and the water phase.

US Patent:

7504265, Mar 17, 2009

Filed:

Jun 5, 2006

Appl. No.:

11/447754

Inventors:

David S. Clague - Livermore CA, US
Elizabeth K. Wheeler - Livermore CA, US
Abraham P. Lee - Irvine CA, US

Assignee:

Lawrence Livermore National Security, LLC - Livermore CA

International Classification:

G01N 33/543

US Classification:

436518, 436532, 436534, 436800, 436805, 435 71, 4352831, 4352871, 4352887, 422 8205, 422 8208, 422213, 422215

Abstract:

A flow cytometer includes a flow cell for detecting the sample, an oil phase in the flow cell, a water phase in the flow cell, an oil-water interface between the oil phase and the water phase, a detector for detecting the sample at the oil-water interface, and a hydrophobic unit operatively connected to the sample. The hydrophobic unit is attached to the sample. The sample and the hydrophobic unit are placed in an oil and water combination. The sample is detected at the interface between the oil phase and the water phase.

US Patent:

20040072334, Apr 15, 2004

Filed:

Oct 15, 2002

Appl. No.:

10/272178

Inventors:

William Benett - Livermore CA, US
James Richards - Danville CA, US
Paul Stratton - Brentwood CA, US
Elizabeth Wheeler - Livermore CA, US
Peter Krulevitch - Pleasanton CA, US
Steve Visuri - Livermore CA, US
John Dzenitis - Danville CA, US

Assignee:

The Regents of the University of California

International Classification:

C12M001/38

US Classification:

435/286100, 435/303100

Abstract:

A thermalcycler for processing a sample holder includes a first thermalcycler body with a first face and a second thermalcycler body with a second face. A cavity for receiving the sample holder is formed in at least one of the first face or the second face. A thermalcycling unit is operatively connected to the cavity.

US Patent:

20060257907, Nov 16, 2006

Filed:

Apr 13, 2006

Appl. No.:

11/405128

Inventors:

Elizabeth Wheeler - Livermore CA, US
Christopher Bailey - Pleasanton CA, US
Allen Christian - Madison WI, US

International Classification:

C12Q 1/68
C12P 19/34

US Classification:

435006000, 435091200

Abstract:

A system for nucleic acid capture and amplification comprising introducing a sample potentially containing the nucleic acid into a packed bed wherein the nucleic acid adheres to the packed bed, introducing an amplification mix into the packed bed, and thermal cycling the packed bed and the nucleic acid between denaturation and annealing temperatures for PCR amplification. One embodiment provides an apparatus for DNA capture and amplification comprising a tubing or housing having a cavity, bed media in the cavity, and a heater operatively connected to the tubing or housing.

US Patent:

20070292889, Dec 20, 2007

Filed:

Jun 16, 2006

Appl. No.:

11/455211

Inventors:

Christopher Bailey - Pleasanton CA, US
Perry Bell - Tracy CA, US
Kodumudi Venkateswaran - Livermore CA, US
Allen Christian - Madison WI, US
Elizabeth Wheeler - Livermore CA, US

International Classification:

G01N 33/53
C12M 3/00
G01N 33/551

US Classification:

435007100, 436524000, 435287200

Abstract:

A system for immunoassaying a sample comprising providing magnetic beads, connecting signal molecules to the beads, connecting the sample to the magnetic beads with the connected signal molecules, magnetically trapping the magnetic beads with the connected signal molecules and the sample, lysising the sample, and analyzing the sample.

US Patent:

20090209030, Aug 20, 2009

Filed:

Mar 31, 2009

Appl. No.:

12/415623

Inventors:

William J. Benett - Livermore CA, US
James B. Richards - Danville CA, US
Paul L. Stratton - Brentwood CA, US
Elizabeth K. Wheeler - Livermore CA, US
Peter Krulevitch - Pleasanton CA, US
Steve Visuri - Livermore CA, US
John M. Dzenitis - Danville CA, US

International Classification:

C12M 1/02
H05K 3/00

US Classification:

4353031, 29829

Abstract:

A thermalcycler is constructing with a first thermalcycler body section of a flexible circuit material or a circuit board material. The first thermalcycler body section has a first face. A first cavity portion is formed in the first face. A second thermalcycler body section is constructed of a flexible circuit material or a circuit board material. The second thermalcycler body section has a second face. A second cavity portion is formed in the second face. When the first cavity portion and the second cavity portion are positioned together they form a cavity. A thermalcycler unit is positioned in the cavity. The first thermalcycler body section and the second thermalcycler body section are connected together with the first face and the face opposed to each other and the thermalcycler unit operatively connected to the first cavity portion and the second cavity portion.

US Patent:

20110027874, Feb 3, 2011

Filed:

Oct 7, 2010

Appl. No.:

12/899924

Inventors:

Elizabeth K. Wheeler - Livermore CA, US
Christopher G. Bailey - Pleasanton CA, US
Allen T. Christian - Madison WI, US

International Classification:

C12M 1/00

US Classification:

4352891

Abstract:

A system for nucleic acid capture and amplification comprising introducing a sample potentially containing the nucleic acid into a packed bed wherein the nucleic acid adheres to the packed bed, introducing an amplification mix into the packed bed, and thermal cycling the packed bed and the nucleic acid between denaturation and annealing temperatures for PCR amplification. One embodiment provides an apparatus for DNA capture and amplification comprising a tubing or housing having a cavity, bed media in the cavity, and a heater operatively connected to the tubing or housing.

US Patent:

20140057276, Feb 27, 2014

Filed:

Nov 1, 2013

Appl. No.:

14/070395

Inventors:

Roald N. Leif - San Ramon CA, US
Elizabeth Wheeler - Livermore CA, US

Assignee:

Lawrence Livermore National Security, LLC - Livermore CA

International Classification:

C12Q 1/68

US Classification:

435 612

Abstract:

A simulant that includes a carrier and DNA encapsulated in the carrier. Also a method of making a simulant including the steps of providing a carrier and encapsulating DNA in the carrier to produce the simulant.