Elizabeth L Wheeler

US Patent:

20180246076, Aug 30, 2018

Filed:

Feb 21, 2018

Appl. No.:

15/901766

Inventors:

- Livermore CA, US
Chao Huang - San Jose CA, US
Anna Nikolaevna Ivanovskaya - Mountain View CA, US
Kris Kulp - Livermore CA, US
Elizabeth K. Wheeler - Livermore CA, US

International Classification:

G01N 33/483
C12M 1/34

Abstract:

A sensor array for simultaneously measuring electrophysiological responses and contractility responses of a tissue includes: a substrate; a multi-electrode array (MEA) disposed in or on the substrate; and a plurality of interdigitized electrodes (IDEs) disposed in or on the substrate. The MEA and the IDEs are interpenetrating within a plane substantially parallel to an upper surface of the substrate. Systems for measuring such responses using the sensor array may also include contacts and/or connectors for interfacing with external control devices, electrodes, and cell culture components such as a chamber and lid. Fabrication techniques for making such systems include: forming a sensor array comprising an interpenetrating arrangement of IDEs and electrodes of a MEA in or on a substrate surface; forming a plurality of contacts for interfacing the system with one or more external devices in or on the substrate surface; and forming leads between the plurality of contacts and the sensor array.