Ellen B Baxter

US Patent:

6426356, Jul 30, 2002

Filed:

Nov 16, 1999

Appl. No.:

09/440869

Inventors:

Ellen W. Baxter - Glenside PA
Michele C. Jetter - Norristown PA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

C07D40906

US Classification:

514365, 514397, 5143114, 5143151, 548205

Abstract:

Certain imidazoethyl thiophenes/thiazoles and benzothiophenes of the formula: where Z is CH or N; and X is independently selected from the group consisting of hydrogen, C alkyl, bromine, chlorine, iodide, trifluoromethyl, C alkoxy and nitro; are -adrenoceptor agonists/antagonists which are useful in the treatment of hypertension, glaucoma, sexual dysfunction, depression, attention deficit hyperactivity disorder, the need for anesthesia, cardiac arrythmia or the need for analgesia.

US Patent:

6465486, Oct 15, 2002

Filed:

Mar 10, 2000

Appl. No.:

09/524451

Inventors:

Ellen W. Baxter - Glenside PA
Robert E. Boyd - Horsham PA
John R. Carson - Norristown PA
Michele C. Jetter - Norristown PA
Allen B. Reitz - Lansdale PA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 3147

US Classification:

514311, 514314, 546167, 546165, 546178, 5462727, 5462751, 546341

Abstract:

Certain imidazo pyridines/quinolines of the formula: where n is 0, 1, 2; X is independently selected from the group consisting of C alkyl, bromine, chlorine, iodide, trifluoromethyl, C alkoxy, âSO NH , nitro, and two adjacent X may be fused to form the moiety: âwhereby a saturated, partially unsaturated or aromatic six-membered fused ring is formed; Y is independently selected from the group consisting of hydrogen, hydroxy, C alkyl, C alkoxy, trifluoromethyl and phenyl; and Z is independently selected from the group consisting of hydroxy, C alkyl, bromine, chlorine, iodide, trifluoromethyl, C alkoxy, âSO NH and nitro; are -adrenoceptor modulators which are useful in the treatment of hypertension, glaucoma, sexual dysfunction, depression, attention deficit hyperactivity disorder, Parkinsonism, the need for anesthesia, cardiac arrythmia or the need for analgesia.

US Patent:

6887876, May 3, 2005

Filed:

Dec 11, 2001

Appl. No.:

10/014081

Inventors:

Ellen W. Baxter - Glenside PA, US
Samuel O. Nortey - Elkins Park PA, US
Allen B. Reitz - Lansdale PA, US

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K031/495
A61K031/496
C07D295/125
C07D409/12

US Classification:

51425212, 51425214, 51425503, 514218, 544379, 544393, 544394, 544399, 544400, 540575

Abstract:

Benzamidine derivatives are useful delta-opioid receptor modulators, agonists useful as analgesics and antagonists useful as immunosuppressants, antiinflammatory agents, agents for the treatment of neurological and psychiatric conditions, medicaments for drug and alcohol abuse, agents for treating gastritis and diarrhea, cardiovascular agents and agents for the treatment of respiratory diseases.

US Patent:

7531545, May 12, 2009

Filed:

Oct 25, 2006

Appl. No.:

11/552792

Inventors:

Ellen E. Baxter - Glenside PA, US
Christopher John Creighton - San Diego CA, US
Yifang Huang - Lansdale PA, US
Chi Luo - New Hope PA, US
Michael H. Parker - Chalfont PA, US
Allen B. Reitz - Lansdale PA, US
Charles H. Reynolds - Lansdale PA, US
Tina Morgan Ross - Royersford PA, US
Eric D. Strobel - Warrington PA, US
Brett A. Tounge - Blue Bell PA, US

Assignee:

Janssen Pharmaceutica, N.V. - Beerse

International Classification:

A61K 31/519
C07D 471/04
A61P 25/28

US Classification:

51426411, 544230, 544279

Abstract:

The present invention is directed to novel 2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.

US Patent:

7576105, Aug 18, 2009

Filed:

Dec 21, 2005

Appl. No.:

11/314496

Inventors:

Ellen W. Baxter - Glenside PA, US
Allen B. Reitz - Lansdale PA, US

Assignee:

Janssen Pharmaceutica, NV - Beerse

International Classification:

A61K 31/445
C07D 211/56

US Classification:

514326, 514329, 546224, 546208

Abstract:

The present invention is directed to N-benzyl substituted (piperidin-4-yl)aminobenzamido derivatives which are delta-opioid receptor modulators.

US Patent:

7776882, Aug 17, 2010

Filed:

Feb 6, 2007

Appl. No.:

11/671703

Inventors:

Ellen W. Baxter - Glenside PA, US
Allen B. Reitz - Lansdale PA, US
Christopher John Creighton - San Diego CA, US

International Classification:

A61K 31/44
A61P 25/28
C07D 215/38

US Classification:

514313, 546159

Abstract:

The present invention is directed to 2-amino-3,4-dihydro-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.

US Patent:

7786116, Aug 31, 2010

Filed:

Jan 29, 2009

Appl. No.:

12/362020

Inventors:

Ellen Baxter - Glenside PA, US
Christopher J. Creighton - San Diego CA, US
Chih Yung Ho - Lansdale PA, US
Yifang Huang - Lansdale PA, US
Tianbao Lu - Churchville PA, US
Chi Luo - New Hope PA, US
Allen B. Reitz - Lansdale PA, US
Charles H. Reynolds - Lansdale PA, US
Tina Morgan Ross - Royerford PA, US

Assignee:

Janssen Pharmaceutica N.V. - Beerse

International Classification:

A61K 31/5377
A61K 31/4709
C07D 413/14
C07D 215/38

US Classification:

5142352, 514313, 544128, 546159

Abstract:

The present invention is directed to novel 2-amino-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD), mild cognitive impairment, senility and/or dementia. The compounds of the present invention are inhibitors of β-secretase, also known as β-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2.

US Patent:

7868022, Jan 11, 2011

Filed:

Feb 6, 2007

Appl. No.:

11/671681

Inventors:

Ellen Baxter - Glenside PA, US
Allen B. Reitz - Lansdale PA, US
Umar Saibu Mohomed Maharoof - North Wales PA, US
Yifang Huang - Lansdale PA, US
Christopher John Creighton - San Diego CA, US
Charles H. Reynolds - Lansdale PA, US
Chi Luo - New Hope PA, US
Brett A. Tounge - Blue Bell PA, US
Tina Morgan Ross - Royersford PA, US
Tianbao Lu - Churchville PA, US

Assignee:

Janssen Pharmaceutica NV - Beerse

International Classification:

A61K 31/44
A61P 25/28
C07D 215/38

US Classification:

514313, 546159

Abstract:

The present invention is directed to 2-amino-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.