Ellen Chen

US Patent:

6582583, Jun 24, 2003

Filed:

Nov 30, 1999

Appl. No.:

09/451141

Inventors:

Ellen T. Chen - Germantown MD

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

C25D 1100

US Classification:

205317, 205198, 20440301, 204415, 204418, 4352872, 4352879, 435817, 422 8203

Abstract:

The present invention provides a novel biosensor for the detection of chemicals of interest. The novel biosensor of the present invention comprises an electrode having a catalytically active cyclodextrin attached thereto. The present invention will be useful for the detection of materials in a wide variety of samples. In particular, the present invention will permit the detection of nitrophenyl esters.

US Patent:

8083926, Dec 27, 2011

Filed:

Apr 19, 2007

Appl. No.:

11/785660

Inventors:

Ellen T. Chen - Germantown MD, US

International Classification:

G01N 27/327

US Classification:

205792, 20440301, 977920

Abstract:

The present invention provides a novel biosensor and measuring method. The novel biosensor of the present invention comprises an electrode having a nanopore structured and catalytically active cyclodextrin attached thereto. The biosensor of the present invention has demonstrated robust analytical performance for direct glucose measurement without mediators or without using native enzyme, which is especially beneficial in the hypoglycemia range.

US Patent:

8632925, Jan 21, 2014

Filed:

Oct 25, 2012

Appl. No.:

13/659974

Inventors:

Ellen Tuanying Chen - Germantown MD, US

International Classification:

H01M 8/10

US Classification:

429491, 429482, 429492, 429506

Abstract:

An electrolyte-free, oxygen-free, high power, and energy dense single fuel cell device is provided, along with methods for making and use. The fuel cell device is based on an electron-relay function using a nanostructured membrane prepared by cross-linking polymers, and having embedded within the membrane, a reactant. Use of the fuel cell device does not produce water, or CO2, and no oxygen is needed. The rechargeability of the fuel cell device revealed it can function as a portable battery.

US Patent:

8641876, Feb 4, 2014

Filed:

Nov 21, 2011

Appl. No.:

13/373576

Inventors:

Ellen Tuanying Chen - Germantown MD, US

International Classification:

G01N 27/327

US Classification:

20440301, 20440306, 977920, 977924, 977948, 977959

Abstract:

The present invention provides a novel device for biosensing and energy storage. The present invented device comprises an electrode having a nanopore structured and bio-communicationally active cyclodextrin attached thereto. The device has demonstrated robust analytical performances for direct single subtype breast cancer measurements without mediators, or native enzyme, and without antibodies labeling; the device is capable to store energy by direct bio-communication with the living cancer cells at real time is demonstrated. It is beneficial in the health care diagnostic applications.

US Patent:

20210341411, Nov 4, 2021

Filed:

May 3, 2021

Appl. No.:

17/306736

Inventors:

Ellen T. Chen - Rockville MD, US

International Classification:

G01N 27/327
G01N 27/48
G01N 27/416
H01L 39/12
H01L 39/22

Abstract:

Topological superconductive and memristive nanostructured toroidal-tower array devices are invented for direct electrochemical sensing of multiple biomarkers based on the biomimetic glucose . . . pyruvate . . . acetyl CoA (ACoA) fuel energy pathway of mitochondria. The device comprises flexible fractional Josephson junctions (FFJJ) made of innate organometallic protein cross-linked with conductive polymers forming a first layer membrane on the electrode surface, a medium comprising of glucose and acetyl CoA (ACoA) molecules (as the GA medium), serves as an insulator or a conductor when pyruvate molecules activated the medium, and the second layer comprising of an innate Heat Shock Protein (HSP) cross-linked with the similar polymers on top of the first layer. Cooper-pairs reentry between the state of superconductivity at room temperature and the memristive state are enabled through a molecular “Valve” GA medium activated by a biomarker to switch the electron move in a 3D horizontal-vertical pathway from low Josephson frequency to high Josephson frequency, enabled the device to direct sensitive and quantitative sensing multiple-biomarkers without antibody or labeling, wherein many applications are discussed.

US Patent:

20200362384, Nov 19, 2020

Filed:

Jan 14, 2020

Appl. No.:

16/742745

Inventors:

ELLEN TUANYING CHEN - ROCKVILLE MD, US

International Classification:

C12Q 1/00
G01N 27/414
H01L 27/18
H01L 39/02
H01L 39/12
H01L 39/22

Abstract:

A multiple functioning superconductive device was invented based on Toroidal Josephson Junction (FFTJJ) array with 3D-cage structure self-assembled organo-metallic superlattice membrane. The device not only mimics the structure and function of an activated Matrix Metalloproteinase-2 (MMP-2) protein, but also mimics the cylinder structure of the Heat Shock Protein (HSP60) protein, that works at room temperature under a normal atmosphere, and without external electromagnetic power applied. The device enabled direct rapid real-time monitoring atto-molarity concentration ATP in biological specimens and was able to define the anti-inflammatory and pro-inflammatory status revealed a transitional range of ATP concentration under antibody-free, tracer-free and label-free conditions.

US Patent:

20200264130, Aug 20, 2020

Filed:

May 2, 2020

Appl. No.:

16/865340

Inventors:

ELLEN TUANYING CHEN - ROCKVILLE MD, US

International Classification:

G01N 27/416
G01N 27/27
G01N 33/487
H01L 27/28
H01L 51/00
C12Q 1/00

Abstract:

Multiple Josephson toroidal vertex quantum superconductive/memristive and superconductive/memcapacitive devices were invented with various superlattice structures, which work at room temperature without an applied external magnetic flux. The first type of the superlattices of the devices comprises of multiple-layers of organometallic polymers on gold chips by self-assembling that mimics the function of Matrix Metalloproteinase-2 (MMP-2). Another type of quantum superconductor/memristor comprises of multiple-organic polymers cross-linked with MMP-2 protein forming Josephson toroidal vertex on the gold surface. Models of the quantum superconductive/memristive and superconductive/memcapacitive devices were fabricated in nano superlattice structures and the devices module configurations were described. Three different methods were used to evaluate the devices' applications in sub fg/mL collagen-1 sensing, energy storage, and the super-position characteristics as a potential quantum bit device. The superconductivity, memristive, and memcapacitive functions were also evaluated in multiple methods, respectively.

US Patent:

20200018767, Jan 16, 2020

Filed:

Jul 15, 2019

Appl. No.:

16/512356

Inventors:

ELLEN TUANYING CHEN - ROCKVILLE MD, US

International Classification:

G01N 33/68
G01N 27/27
G01N 27/416
H01L 27/28

Abstract:

A memristive/memcapacitive device with vertex double-helical polarized biomimetic protein nanotubules forming double membranes with potential gradient mimicking mitochondria's inner double membrane was invented. The memristive/memcapacitive device comprises a cross-linked conductive organic polymer having a single-wall cross-bar polarized nanotube self-assembling membrane (SAM) on a gold chip with a minimum 5 nm space between the nanotubes. Under an applied potential, a pair of vertex double-helical circular current flow induced the Fermi arcs states promoting a direct chelating with zinc ions of the Matrix Metalloproteinase (MMP-2), that made a dual-functioning direct ultrasensitive detection of protein in an attomolar concentration possible without a procedure of cycteine switch under label-free, probe-free and reagent-free conditions. The energy harvesting feature is also disclosed.