Emanuel Calenoff

US Patent:

6892140, May 10, 2005

Filed:

Nov 27, 2000

Appl. No.:

09/723307

Inventors:

Emanuel Calenoff - Chicago IL, US
Charles Ditlow - Chicago IL, US

Assignee:

Enteron, Inc. - Oak Brook IL

International Classification:

G01N033/48
A61K038/14
A61K045/00
A61K039/00
A01N063/00

US Classification:

702 19, 424 851, 424 852, 424 9371, 4241841, 530322, 702 20

Abstract:

This invention relates to novel general methods and compositions that provide cancer-specific or highly cancer-associated antigens useful for diagnosis and treatment of cancer.

US Patent:

20020193295, Dec 19, 2002

Filed:

May 4, 2001

Appl. No.:

09/848967

Inventors:

Emanuel Calenoff - Alameda CA, US
Charles Ditlow - Chicago IL, US

International Classification:

C12Q001/70
G01N033/554
G01N033/569
G01N033/53
G01N033/542
A61K039/00
C12N005/06

US Classification:

514/012000, 435/005000, 435/007320, 435/326000, 530/388100, 435/007900

Abstract:

Novel general methods and compositions provide specific or highly associated antigenic peptides useful for diagnosis and treatment of diseases caused by microorganisms, allergens or other proteins. Specific or highly associated peptide antigens are also useful for diagnosis, treatment and prevention of auto-immune diseases, allergens and other diseases.

US Patent:

20050048588, Mar 3, 2005

Filed:

Jul 19, 2004

Appl. No.:

10/894359

Inventors:

Emanuel Calenoff - Chicago IL, US
Charles Ditlow - Chicago IL, US

International Classification:

C12Q001/68
G01N033/574
C07K014/47

US Classification:

435007230, 530350000

Abstract:

This invention relates to novel general methods and compositions that provide cancer-specific or highly cancer-associated antigens useful for diagnosis and treatment of cancer.

US Patent:

20050169912, Aug 4, 2005

Filed:

Nov 2, 2004

Appl. No.:

10/979890

Inventors:

Emanuel Calenoff - Alameda CA, US
Charles Ditlow - Chicago IL, US

International Classification:

A61K039/395
A61K039/00
G01N033/53
C07K014/47
C07K016/18

US Classification:

424130100, 530350000, 530388100, 424185100, 435007100

Abstract:

Novel general methods and compositions provide specific or highly associated antigenic peptides useful for diagnosis and treatment of diseases caused by microorganisms, allergens or other proteins. Specific or highly associated peptide antigens are also useful for diagnosis, treatment and prevention of auto-immune diseases, allergens and other diseases.

US Patent:

20050272097, Dec 8, 2005

Filed:

Feb 18, 2005

Appl. No.:

11/062186

Inventors:

Emanuel Calenoff - Alameda CA, US

International Classification:

G01N033/53
G01N033/567

US Classification:

435007200

Abstract:

Diseases caused by or affected by specific antibodies and/or T lymphocytes that complex with self-molecules in a subject are detected by identifying antigen specific antibodies and/or effector T lymphocytes against the antigen, in a biological fluid of an affected subject. This identification opens up treatment possibilities, for example, by desensitization.

US Patent:

20080267988, Oct 30, 2008

Filed:

Apr 11, 2008

Appl. No.:

12/082515

Inventors:

Emanuel Calenoff - Dallas TX, US

Assignee:

Enteron Limited Partnership - Oak Brook IL

International Classification:

A61K 39/00
G01N 33/53
G01N 33/567
C07K 16/42

US Classification:

4241851, 435 71, 435 721, 5303872

Abstract:

Optimization and validation of a serum test confirms symptomatic autoimmune diseases e.g. multiple sclerosis (MS) or rheumatoid arthritis, and identifies early, silent diseases. The methods involve testing of subject sera for the presence of epitope-specific serum IgE and also non-IgE antibodies. The tests are immunoassays wherein serum autoantibodies complex with peptides structurally mimicking humoral, autoimmune epitopes on, for example, myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG) and proteolipid protein (PLP) for MS. Each peptide: (1) is 5-6 amino acids long; (2) structurally and functionally mimics the surface region of its parent protein; and (3) offers a correct fit for the antigen binding site of a single specific autoantibody. Relapse prediction tests and therapies employ the peptides.

US Patent:

59555840, Sep 21, 1999

Filed:

Apr 26, 1993

Appl. No.:

8/053451

Inventors:

Charles C. Ditlow - Fremont CA
Francis W. Chen - San Francisco CA
Emanuel Calenoff - Chicago IL

Assignee:

Charter Ventures - Palo Alto CA

International Classification:

C07K 1618
C12P 2108

US Classification:

5303882

Abstract:

The subject invention provides a naturally occurring antigen indicative of the presence of atherosclerotic plaque. The subject invention provides a murine-human chimeric monoclonal antibody which specifically binds to an antigen indicative of the presence of atherosclerotic plaque; and methods and reagents involving the use of the murine-human chimeric monoclonal antibody. The subject invention provides a CDR-grafted antibody; and methods and reagents involving the use of the CDR-grafted antibody. The subject invention provides a surrogate antigen; methods and reagents involving the use of the surrogate antigen, preparation of the surrogate antigen, antibodies generated from the surrogate antigen.

US Patent:

55675948, Oct 22, 1996

Filed:

Dec 20, 1993

Appl. No.:

8/170017

Inventors:

Emanuel Calenoff - Chicago IL

Assignee:

Enteron, L.P. - Oak Brook IL

International Classification:

G01N 3353
G01N 33554
G01N 33569

US Classification:

435 732

Abstract:

A library of isolated and purified antigens specific for a microorganism is a set of individual molecules. The library forms antigen-antibody complexes useful in the context of diagnosing and treating conditions associated with a specific microorganism such as H. pylori-induced gastro-duodenal disease. For the antigen-antibody complexes in question the antibody is an immunoglobulin, which is IgE if the antigens are allergens. Complexes with IgA, IgG and IgM are also useful. By this multivariate approach, a specific condition is diagnosed with high sensitivity and specificity by determining whether complexes form between a specific antigen library and a biological sample which contains immunoglobulins from an individual. Such libraries also are useful for immunotherapy.