Eric M Carlson

US Patent:

6414494, Jul 2, 2002

Filed:

Apr 13, 2000

Appl. No.:

09/548563

Inventors:

Stephan E. Schmidt - Woburn MA 01801
Kristin Powers Goppel - Shrewsbury MA 01545
Eric J. Carlson - Sudbury MA 01776

International Classification:

G01N 2762

US Classification:

324468

Abstract:

In a flame ionization sensor type gas combustion control apparatus, the sensor tip, or probe, exposed to the flame is constructed and arranged according to materials and shapes which promote mechanical deformation of the sensor due to thermal expansion and contraction. The mechanical deformation will cause cracks to open in the contaminant layers surrounding the probe, enabling the sensor to perform as intended even though insulative contaminant build up is present.

US Patent:

6693433, Feb 17, 2004

Filed:

May 9, 2002

Appl. No.:

10/142031

Inventors:

Stephan E. Schmidt - Woburn MA
Kristin Powers Goppel - Shrewsbury MA
Eric J. Carlson - Sudbury MA

Assignee:

Gas Research Institute - Des Plaines IL

International Classification:

G01N 2762

US Classification:

324468

Abstract:

In a flame ionization sensor type gas combustion control apparatus, the sensor tip, or probe, exposed to the flame is constructed and arranged according to materials and shapes which promote mechanical deformation of the sensor due to thermal expansion and contraction. The mechanical deformation will cause cracks to open in the contaminant layers surrounding the probe, enabling the sensor to perform as intended even though insulative contaminant build up is present.

US Patent:

20050118482, Jun 2, 2005

Filed:

Sep 17, 2004

Appl. No.:

10/944273

Inventors:

Suresh Sriramulu - Arlington MA, US
Anant Singh - Burlington MA, US
Johannes Thijssen - Redmond WA, US
Eric Carlson - Sudbury MA, US

Assignee:

TIAX LLC - Cambridge MA

International Classification:

H01M008/24
B05D005/12

US Classification:

429034000, 427115000, 429013000

Abstract:

An interconnect utilizing a metal matrix composite of at least one metal selected from the group consisting of copper, oxide dispersion strengthened copper, aluminum, titanium, and alloys thereof, and at least one reinforcing material selected from the group consisting of carbon, boron carbide, silicon carbide, zirconium carbide, hafnium carbide, tantalum carbide, titanium carbide, zirconium diboride, hafnium diboride, tantalum diboride, titanium diboride, silicon dioxide, aluminum oxide, alumino-silicate, silicon nitride, and aluminum nitride is disclosed. The interconnect can be utilized as a component of an electrochemical device. The interconnect can have a coefficient of thermal expansion that is within about 10% of a coefficient of thermal expansion of a component or assembly of the electrochemical device.

US Patent:

20170202981, Jul 20, 2017

Filed:

Jun 24, 2015

Appl. No.:

15/321025

Inventors:

Joy GHOSH - Boston MA, US
Thaddeus Peter DRYJA - Milton MA, US
Michael ROGUSKA - Ashland MA, US
Eric C. CARLSON - Burleson TX, US

Assignee:

Novartis AG - Basel

International Classification:

A61K 49/00
A61K 9/00

Abstract:

The invention provides compositions for rendering a vitreous cavity visible during a surgical procedure to alleviate a structural disorder caused by the vitreous in an eye, and methods of using the compositions. The compositions are vitreous delineating agents that comprise a hyaluronan binding peptide linked to an optically detectable moiety. Such compositions can be in a formulation that may be a solution, a suspension, or an emulsion, and would be injected into the vitreous shortly prior to use. The composition may additionally contain a therapeutic agent, a diagnostic agent, or a chemosensing material, in use, the composition marks or delineates the vitreous by binding preferentially to the hyaluronan that permeates the vitreous humor and binding little or not at all to surrounding tissues such as the retina. The interface between the labelled vitreous humor and the non-labelled surrounding vital tissues produces a visible signal, thereby allowing a surgeon to clearly visualize the entire vitreous cavity and distinguish it from vital ocular structures. Use of the method improves the accuracy and safety of a vitrectomy and thus prevents suboptimal outcomes or the need for repeated procedures. The compositions comprising chemosensing material are useful as long-lasting biosensors, which when used in the vitreous enable repetitive, non-invasive, in vivo measurements of metabolites or pharmacologic agents in the vitreous of animals or humans.

US Patent:

20140228430, Aug 14, 2014

Filed:

Jan 16, 2014

Appl. No.:

14/156832

Inventors:

- Fort Worth TX, US
Mark R. Hellberg - Needham MA, US
Peter G. Klimko - Fort Worth TX, US
Kerry L. Markwardt - Burleson TX, US
John M. Yanni - Burleson TX, US
Eric C. Carlson - Burleson TX, US

Assignee:

Alcon Research, Ltd. - Fort Worth TX

International Classification:

C07D 309/30
A61K 9/00
C07C 69/675
C07C 235/06
C07C 59/105

US Classification:

514460, 514629, 514557, 514546

Abstract:

The topical ophthalmic use of 5,6,7-trihydroxyheptanoic acid and analogs for the acceleration of corneal wound healing in humans, is disclosed.