Eric W Gordon

US Patent:

6531470, Mar 11, 2003

Filed:

Aug 30, 2000

Appl. No.:

09/652250

Inventors:

Mikhail F. Gordeev - San Leandro CA
Gary W. Luehr - Fremont CA
Dinesh V. Patel - Fremont CA
Zhi-Jie Ni - Fremont CA
Eric Gordon - Palo Alto CA

Assignee:

Pharmacia Upjohn Company - Kalamazoo MI

International Classification:

C07D41312

US Classification:

5142368, 514376, 544137, 548229, 548232

Abstract:

Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

US Patent:

6562844, May 13, 2003

Filed:

Dec 28, 2001

Appl. No.:

10/034754

Inventors:

Mikhail F. Gordeev - San Leandro CA
Gary W. Luehr - Fremont CA
Dinesh V. Patel - Fremont CA
Zhi-Jie Ni - Fremont CA
Eric Gordon - Palo Alto CA

Assignee:

Pharmacia Upjohn Company - Kalamazoo MI

International Classification:

C07D41312

US Classification:

514340

Abstract:

Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

US Patent:

20050004174, Jan 6, 2005

Filed:

Jul 2, 2004

Appl. No.:

10/884717

Inventors:

Mikhail Gordeev - Castro Valley CA, US
Gary Luehr - Hayward CA, US
Zhi-Jie Ni - Fremont CA, US
Dines Patel - Fremont CA, US
Eric Gordon - Palo Alto CA, US

International Classification:

A61K031/4439
A61K031/422
C07D413/02
C07D263/16

US Classification:

514340000, 514376000, 548229000, 546274100

Abstract:

Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

US Patent:

62391526, May 29, 2001

Filed:

Jan 22, 1999

Appl. No.:

9/235771

Inventors:

Mikhail F. Gordeev - San Leandro CA
Gary W. Luehr - Fremont CA
Dinesh V. Patel - Fremont CA
Zhi-Jie Ni - Fremont CA
Eric Gordon - Palo Alto CA

Assignee:

Pharmacia & Upjohn Company - Kalamazoo MI

International Classification:

C07D41312
A61K 31422

US Classification:

514340

Abstract:

Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

US Patent:

55592562, Sep 24, 1996

Filed:

Jun 25, 1993

Appl. No.:

8/079978

Inventors:

Eric M. Gordon - Palo Alto CA
Joel C. Barrish - Holland PA
Gregory S. Bisacchi - Lawrenceville NJ
Chong-Qing Sun - East Windsor NJ
Joseph A. Tino - Lawrenceville NJ
Gregory D. Vite - Trenton NJ
Robert Zahler - Pennington NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07D40112

US Classification:

552303

Abstract:

Novel aminediol compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds in inhibiting retroviral protease, particularly useful in the treatment and/or prevention of HIV infection (AIDS).

US Patent:

57769338, Jul 7, 1998

Filed:

May 31, 1995

Appl. No.:

8/456125

Inventors:

Eric M. Gordon - Palo Alto CA
Joel C. Barrish - Holland PA
Gregory S. Bisacchi - Lawrenceville NJ
Chong-Qing Sun - East Windsor NJ
Joseph A. Tino - Lawrenceville NJ
Gregory D. Vite - Trenton NJ
Robert Zahler - Pennington NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

A61K 31445
A61K 31535

US Classification:

5142375

Abstract:

Novel aminediol compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds in inhibiting retroviral protease, particularly useful in the treatment and/or prevention of HIV infection (AIDS).

US Patent:

55234305, Jun 4, 1996

Filed:

May 23, 1994

Appl. No.:

8/247743

Inventors:

Dinesh V. Patel - Fremont CA
Scott A. Biller - Ewing NJ
Eric M. Gordon - Palo Alto CA

Assignee:

Bristol-Myers Squibb Company - New York NY

International Classification:

C07C23300

US Classification:

554 40

Abstract:

Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, and inhibition of cholesterol biosynthesis, are effected by compounds of the formula ##STR1## their enantiomers, diastereomers, and pharmaceutically acceptable salts, prodrugs, and solvates, wherein: X is --ONR. sup. 1 C(O)--, --N(OR. sup. 1)C(O)--, --NR. sup. 1 C(O)--, --C(O)NR. sup. 1 --, --NR. sup. 1 S(O. sub. 2)--, --C(O)O--, --OC(O)--, --O--, --NR. sup. 1 -- or --(S)q; Y and Z are each independently --CO. sub. 2 R. sup. 2, --SO. sub. 3 R. sup. 2 or --P(O)(OR. sup. 2)(OR. sup. 3); R is alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkenylene or aryl; R. sup. 1, R. sup. 2 and R. sup. 3 are each independently hydrogen, alkyl, aryl or aralkyl; m and n are each independently 0 or an integer from 1 to 5; p is 0 or 1; and q is an integer from 1 to 2.

US Patent:

57600368, Jun 2, 1998

Filed:

May 31, 1995

Appl. No.:

8/455295

Inventors:

Eric M. Gordon - Palo Alto CA
Joel C. Barrish - Holland PA
Gregory S. Bisacchi - Lawrenceville NJ
Joseph A. Tino - Lawrenceville NJ
Gregory D. Vite - Trenton NJ
Robert Zahler - Pennington NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princton NJ

International Classification:

A61K 31445
A61K 31535
C07D295192

US Classification:

5142375

Abstract:

Novel aminediol compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds in inhibiting retroviral protease, particularly useful in the treatment and/or prevention of HIV infection (AIDS).