Eric J Gordon

US Patent:

48898740, Dec 26, 1989

Filed:

Mar 14, 1988

Appl. No.:

7/183406

Inventors:

Martin F. Haslanger - Ridgewood NJ
Eric M. Gordon - Pennington NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07C 8310
A61K 73185

US Classification:

514575

Abstract:

In accordance with the present invention, new hydroxamic acid derivatives useful as. DELTA. sup. 5 -lipoxygenase inhibitors are provided. These new compounds have the general formula ##STR1## wherein ##STR2## are cycloalkyl groups which may be the same or different; R is hydrogen, lower alkyl, aryl, lower alkenyl, cycloalkyl or aralkyl; n is an integer from 3 to 12; and m is an integer from 3 to 12. Further in accordance with the present invention, a method for using the above compounds is provided.

US Patent:

46819371, Jul 21, 1987

Filed:

Sep 27, 1982

Appl. No.:

6/424132

Inventors:

William A. Slusarchyk - Belle Mead NJ
Tamara Dejneka - Skillman NJ
William H. Koster - East Amwell Township, Hunterdon County NJ
Eric M. Gordon - Pennington NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07F 965
A61K 31675

US Classification:

540355

Abstract:

Antimicrobial activity is exhibited by. beta. -lactams having a ##STR1## substituent in the 1-position and an acylamino substituent in the 3-position, or a pharmaceutically acceptable salt thereof; wherein Y is oxygen or sulfur and R. sub. 5 is hydroxyl, alkyl, substituted alkyl, phenyl, substituted phenyl, alkoxy, alkylthio, (substituted alkyl)oxy, (substituted alkyl)thio, phenyloxy, phenylthio, (substituted phenyl)oxy or (substituted phenyl)thio.

US Patent:

50495771, Sep 17, 1991

Filed:

Jan 29, 1990

Appl. No.:

7/471461

Inventors:

Ravi K. Varma - Belle Mead NJ
Eric M. Gordon - Pennington NJ
Sam T. Chao - East Windsor NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07D20724
A61K 3140

US Classification:

514409

Abstract:

Antihypercholesterolemic activity has been discovered in compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein: Z is ##STR2## X is lower alkyl, lower alkenyl, or lower alkenyl; R. sup. 1 is hydrogen, alkyl, alkenyl, aryl, alkylaryl, or substituted aryl having one or more substituents; and one of R. sup. 2 and R. sup. 3 is hydrogen and the other is hydrogen, alkyl, alkenyl, aryl, alkylaryl or alkenyl aryl; or R. sup. 2 and R. sup. 3 are both lower alkyl; or R. sup. 2 and R. sup. 3 together complete a substituted or unsubstituted hydrocarbon ring that is cycloalkyl or cycloalkenyl with substituents as defined in the specification.

US Patent:

46955860, Sep 22, 1987

Filed:

Sep 23, 1986

Appl. No.:

6/910597

Inventors:

Ravi K. Varma - Belle Mead NJ
Sam T. Chao - East Windsor NJ
Eric M. Gordon - Pennington NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

A61K 31557
C07D30700

US Classification:

514469

Abstract:

7-Oxabicyclo(2. 2. 1)heptane-based N-hydroxy-N-alkyl (or aryl) ureas, carbamic acids and carbamothioic acids are disclosed having the general formula ##STR1## wherein R. sub. 1 is hydrogen, lower alkyl, alkenyl, aryl or aralkyl; R. sub. 2 is hydrogen, lower alkyl, aralkyl, alkanoyl or aroyl; R. sub. 3 is lower alkyl, alkenyl or alkynyl; A is --CH. sub. 2 --CH. dbd. CH-- or a single bond; X is oxygen, sulfur or NH; n is an integer from 1 to 8; and all stereoisomers thereof. These new compounds have been found to simultaneously inhibit the enzymes arachidonic acid cyclooxygenase and arachidonic acid 5-lipoxygenase and are therefore useful as antiinflammatory, antiasthma and antipsoriatic agents.

US Patent:

45351767, Aug 13, 1985

Filed:

May 29, 1984

Appl. No.:

6/615014

Inventors:

Sesha I. Natarajan - Neshanic Station NJ
Eric M. Gordon - Pennington NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07C125063
C07C101024

US Classification:

560 27

Abstract:

Intermediates of the formula ##STR1## are disclosed. These compounds are useful in preparing substituted peptide compounds which possess hypotensive and analgesic activity.

US Patent:

46237291, Nov 18, 1986

Filed:

Jul 22, 1982

Appl. No.:

6/400798

Inventors:

Sesha I. Natarajan - Neshanic Station NJ
Eric M. Gordon - Pennington NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07D21360

US Classification:

546256

Abstract:

Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.

US Patent:

50495780, Sep 17, 1991

Filed:

Mar 9, 1990

Appl. No.:

7/490901

Inventors:

Ravi K. Varma - Belle Mead NJ
Eric M. Gordon - Pennington NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

A61K 3140
C07D20708
C07D40506

US Classification:

514409

Abstract:

Antihypercholesterolemic activity is exhibited by novel compounds of the formula ##STR1## wherein: Z is ##STR2## X is lower alkyl or lower alenyl; R. sup. 1 is aryl or alkyl; R. sup. 2 and R. sup. 3 are the same or different and are hydrogen, or lower alkyl or aryl, or R. sup. 2 and R. sup. 3 taken together to form a cycloalkyl group; and R. sup. 4 is hydrogen, lower alkyl, or alkali metal (such as sodium, lithium, or potassium) or a radical such as ammonium. Methods of use and novel intermediates of these compounds are also provided.

US Patent:

53691237, Nov 29, 1994

Filed:

Oct 9, 1992

Appl. No.:

7/958849

Inventors:

Dinos P. Santafianos - Maplewood NJ
Kathleen M. Poss - Lawrenceville NJ
Eric M. Gordon - Palo alto CA
Peggy J. McCann - West Trenton NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

A61K 3140
A61K 31365
C07D30930
C07C 6974

US Classification:

514428

Abstract:

Novel nitrogen-substituted mevinic acid derivatives which inhibit the activity of HMG-CoA reductase. Pharmaceutical compositions, and methods of use for the treatment or prevention of hypercholesterolemia, atherosclerosis, hyperlipoproteinaemia and hyperlipidemia are provided, as are novel methods for preparation and intermediate compounds.

Address:

108 Country Cor Cir, Venetia, PA 15367

Phone:

4129653418

VIN:

WAUSGAFCXCN001284

Make:

AUDI

Model:

A7

Year:

2012