Eric M Gordon

US Patent:

47989041, Jan 17, 1989

Filed:

Nov 13, 1987

Appl. No.:

7/119930

Inventors:

Norma G. Delaney - Princeton NJ
Eric M. Gordon - Pennington NJ
Miguel A. Ondetti - Princeton NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07C15311

US Classification:

558254

Abstract:

Acylmercaptoalkanoyl compounds of the formula ##STR1## wherein n is an integer from one to fifteen possess enkephalinase inhibition activity and are useful as analgesic agents.

US Patent:

45129886, Apr 23, 1985

Filed:

Mar 1, 1984

Appl. No.:

6/585058

Inventors:

Harold N. Weller - Pennington NJ
Eric M. Gordon - Pennington NJ
Donald S. Karanewsky - East Windsor NJ
Denis E. Ryono - Princeton NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07D27906
C07D28536
A61K 3155
A61K 3154

US Classification:

514211

Abstract:

Compounds of the formula ##STR1## and X is an oxo substituted thiazine or thiazepine are disclosed. These compounds possess angiotensin converting enzyme inhibition activity and are thus useful as hypotensive agents.

US Patent:

46819371, Jul 21, 1987

Filed:

Sep 27, 1982

Appl. No.:

6/424132

Inventors:

William A. Slusarchyk - Belle Mead NJ
Tamara Dejneka - Skillman NJ
William H. Koster - East Amwell Township, Hunterdon County NJ
Eric M. Gordon - Pennington NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07F 965
A61K 31675

US Classification:

540355

Abstract:

Antimicrobial activity is exhibited by. beta. -lactams having a ##STR1## substituent in the 1-position and an acylamino substituent in the 3-position, or a pharmaceutically acceptable salt thereof; wherein Y is oxygen or sulfur and R. sub. 5 is hydroxyl, alkyl, substituted alkyl, phenyl, substituted phenyl, alkoxy, alkylthio, (substituted alkyl)oxy, (substituted alkyl)thio, phenyloxy, phenylthio, (substituted phenyl)oxy or (substituted phenyl)thio.

US Patent:

50495771, Sep 17, 1991

Filed:

Jan 29, 1990

Appl. No.:

7/471461

Inventors:

Ravi K. Varma - Belle Mead NJ
Eric M. Gordon - Pennington NJ
Sam T. Chao - East Windsor NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07D20724
A61K 3140

US Classification:

514409

Abstract:

Antihypercholesterolemic activity has been discovered in compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein: Z is ##STR2## X is lower alkyl, lower alkenyl, or lower alkenyl; R. sup. 1 is hydrogen, alkyl, alkenyl, aryl, alkylaryl, or substituted aryl having one or more substituents; and one of R. sup. 2 and R. sup. 3 is hydrogen and the other is hydrogen, alkyl, alkenyl, aryl, alkylaryl or alkenyl aryl; or R. sup. 2 and R. sup. 3 are both lower alkyl; or R. sup. 2 and R. sup. 3 together complete a substituted or unsubstituted hydrocarbon ring that is cycloalkyl or cycloalkenyl with substituents as defined in the specification.

US Patent:

46955860, Sep 22, 1987

Filed:

Sep 23, 1986

Appl. No.:

6/910597

Inventors:

Ravi K. Varma - Belle Mead NJ
Sam T. Chao - East Windsor NJ
Eric M. Gordon - Pennington NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

A61K 31557
C07D30700

US Classification:

514469

Abstract:

7-Oxabicyclo(2. 2. 1)heptane-based N-hydroxy-N-alkyl (or aryl) ureas, carbamic acids and carbamothioic acids are disclosed having the general formula ##STR1## wherein R. sub. 1 is hydrogen, lower alkyl, alkenyl, aryl or aralkyl; R. sub. 2 is hydrogen, lower alkyl, aralkyl, alkanoyl or aroyl; R. sub. 3 is lower alkyl, alkenyl or alkynyl; A is --CH. sub. 2 --CH. dbd. CH-- or a single bond; X is oxygen, sulfur or NH; n is an integer from 1 to 8; and all stereoisomers thereof. These new compounds have been found to simultaneously inhibit the enzymes arachidonic acid cyclooxygenase and arachidonic acid 5-lipoxygenase and are therefore useful as antiinflammatory, antiasthma and antipsoriatic agents.

US Patent:

45351767, Aug 13, 1985

Filed:

May 29, 1984

Appl. No.:

6/615014

Inventors:

Sesha I. Natarajan - Neshanic Station NJ
Eric M. Gordon - Pennington NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07C125063
C07C101024

US Classification:

560 27

Abstract:

Intermediates of the formula ##STR1## are disclosed. These compounds are useful in preparing substituted peptide compounds which possess hypotensive and analgesic activity.

US Patent:

51069920, Apr 21, 1992

Filed:

Apr 30, 1990

Appl. No.:

7/516867

Inventors:

David R. Magnin - Plainsboro NJ
Eric M. Gordon - Pennington NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07D27704
C07D41906

US Classification:

548200

Abstract:

3,5-Dihydroxypentanoic acid derivatives are provided which are 6-hydroxy-8-(2,2-dimethyl-1-oxybutoxy-2-methyl)-substituted-thiazolidine derivatives and have the structure ##STR1## wherein Z is ##STR2## R. sup. 6 is an alkali metal, lower alkyl or H; R. sup. 1 and R. sup. 2 are the same or different and are H, lower alkyl or aryl; X is S, O, ##STR3## or a single bond; R. sup. 7 is lower alkyl; R. sup. 3 is lower alkyl or aryl; R. sup. 4 and R. sup. 5 are the same or different and are H or lower alkyl; and --- represents a single bond or a double bond, and are HMG CoA reductase inhibitors and thus are useful as antihypercholesterolemic agents and in treating atherosclerosis, and also as antifungal agents. In addition, novel intermediates for use in preparing the above mevinic acid derivatives are also provided.

US Patent:

48187577, Apr 4, 1989

Filed:

Dec 28, 1987

Appl. No.:

7/140448

Inventors:

Harold N. Weller - Pennington NJ
Eric M. Gordon - Pennington NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

A61K 31535

US Classification:

5142315

Abstract:

Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.