Eric S Jacobsen

US Patent:

6369223, Apr 9, 2002

Filed:

Jan 4, 2001

Appl. No.:

09/755612

Inventors:

Eric N. Jacobsen - Boston MA
Scott E. Schaus - Cambridge MA
Alexander G. Dossetter - Somerville MA
Timothy F. Jamison - Cambridge MA

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C07D28515

US Classification:

544 4, 544 47, 502182, 502210, 502219, 502305

Abstract:

The present invention relates to a process for stereoselective cycloaddition reactions which generally comprises a cycloaddition reaction between a pair of substrates, each either chiral or prochiral, that contain reactive -systems, in the presence of a non-racemic chiral catalyst, to produce a stereoisomerically enriched product. The present invention also relates to novel asymmetric catalyst complexes comprising a metal and an asymmetric tridentate ligand.

US Patent:

6448414, Sep 10, 2002

Filed:

Jul 5, 2001

Appl. No.:

09/899516

Inventors:

Eric N. Jacobsen - Boston MA
Makoto Tokunaga - Wako, JP
Jay F. Larrow - Irvine CA

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C07D31736

US Classification:

549230, 502158, 540604, 544264, 548965, 548969, 549513, 549518, 562 64

Abstract:

The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral catalyst to produce a stereoisomerically- and/or regioisomerically-enriched product. The present invention also relates to hydrolytic kinetic resolutions of racemic and diastereomeric mixtures of epoxides.

US Patent:

6489093, Dec 3, 2002

Filed:

Sep 19, 1997

Appl. No.:

08/933714

Inventors:

Eric N. Jacobsen - Boston MA
Matthew B. Francis - Somerville MA
Nathaniel S. Finney - West Somerville MA

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C12Q 100

US Classification:

435 4, 435 71, 435DIG 14, 436501, 436518

Abstract:

The present invention provides methods and compositions, i. e. synthetic libraries of binding moities, for identifying compounds which bind to a metal atom or to non-metal ions, e. g. , cationic or anionic molecules.

US Patent:

6521561, Feb 18, 2003

Filed:

May 1, 1998

Appl. No.:

09/071842

Inventors:

Eric N. Jacobsen - Boston MA
Matthew S. Sigman - Somerville MA

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

B01J 3100

US Classification:

502162, 502163, 502167, 502168, 502171

Abstract:

The present invention relates to a method and catalysts for the stereoselective addition of a nucleophile to a reactive -bond of a substrate. The chiral, non-racemic catalysts of the present invention constitute the first examples of catalysts for nucleophilic additions that comprise a main-group metal and a tri- or tetra-dentate ligand.

US Patent:

6693206, Feb 17, 2004

Filed:

Aug 22, 2002

Appl. No.:

10/225869

Inventors:

Yi Liu - Weymouth MA
Marcello DiMare - Belmont MA
Salvatore Anthony Marchese - Malden MA
Eric N. Jacobsen - Boston MA
Serge Jasmin - Watertown MA

Assignee:

Rhodia Chirex, Inc. - MA

International Classification:

C07D30132

US Classification:

549541, 549513, 549540

Abstract:

The present invention provides a process for the preparation of an enantiomerically enriched non-racemic chiral diol and an enantiomerically enriched non-racemic chiral epoxy compound by a hydrolytic kinetic resolution reaction. The process includes the step of contacting oxygen and mixture including a racemic chiral epoxy compound, a non-racemic Co(II) complex catalyst, an aromatic carboxylic acid and water, at a temperature and length of time sufficient to produce a mixture of said non-racemic chiral diol and said non-racemic chiral epoxy compound. The present invention also provides a process for the preparation of an enantiomerically enriched non-racemic chiral diol and an enantiomerically enriched non-racemic chiral epoxy compound by a hydrolytic kinetic resolution reaction. This process includes the step of: contacting a racemic chiral epoxy compound and water in the presence of a non-racemic complex of Co(III) having an aryl carboxylate counter-anion, at a temperature and length of time sufficient to produce a mixture of said non-racemic chiral diol and said non-racemic chiral epoxy compound.

US Patent:

6709824, Mar 23, 2004

Filed:

Sep 24, 2001

Appl. No.:

09/962012

Inventors:

Eric N. Jacobsen - Boston MA
Matthew S. Sigman - Somerville MA

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C12Q 168

US Classification:

435 6, 540484, 502172, 502200, 5483361, 548537, 548557, 560103, 560138

Abstract:

The present invention provides methods and compositions, i. e. synthetic libraries of candidate compounds, useful in the discovery and optimization of compounds which catalyze at least one chemical transformation. In certain instances, the subject compounds catalyze a chemoselective, regioselective, stereoselective or enantioselective transformation.

US Patent:

6800766, Oct 5, 2004

Filed:

Jul 26, 2002

Appl. No.:

10/206143

Inventors:

Eric N. Jacobsen - Boston MA
Makoto Tokunaga - Saitama, JP
Jay F. Larrow - Irvine CA

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C08D30100

US Classification:

549230, 502158, 540604, 544264, 548965, 548969, 549296, 549513, 549518, 562 64, 568866

Abstract:

The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral catalyst to produce a stereoisomerically- and/or regioisomerically-enriched product. The present invention also relates to hydrolytic kinetic resolutions of racemic and diastereomeric mixtures of epoxides.

US Patent:

6841667, Jan 11, 2005

Filed:

Jul 7, 2003

Appl. No.:

10/615501

Inventors:

Eric N. Jacobsen - Boston MA, US
Makoto Tokunaga - Saitama, JP
Jay F. Larrow - Irvine CA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C07D20306

US Classification:

540604, 544264, 548965, 548969, 549230, 549296, 549513, 549518, 562 64

Abstract:

The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral catalyst to produce a stereoisomerically- and/or regioisomerically-enriched product. The present invention also relates to hydrolytic kinetic resolutions of racemic and diastereomeric mixtures of epoxides.