Eric Lin

US Patent:

20190017919, Jan 17, 2019

Filed:

Aug 10, 2018

Appl. No.:

16/100726

Inventors:

- Ann Arbor MI, US
Hyeun Joong Yoon - Ann Arbor MI, US
Eric Lin - Ann Arbor MI, US
Max S. Wicha - Ann Arbor MI, US
Lianette Rivera Baez - Ann Arbor MI, US
Diane M. Simeone - Ann Arbor MI, US

Assignee:

The Regents of the University of Michigan - Ann Arbor MI

International Classification:

G01N 15/10
G01N 15/02
B01L 3/00
G01N 33/50
G01N 33/574
G01N 15/00

Abstract:

A microfluidic device for detecting rare cells in a fluid sample comprises the rare cell and other cells. The microfluidic device comprises an inlet for receiving the fluid sample, a labyrinth channel structure in fluid communication with the inlet, and an outlet in fluid communication with the labyrinth channel structure for collecting the rare cells separated from the other cells in the fluid sample. The labyrinth channel structure comprises at least one channel through which the fluid sample flows. The at least one channel has a plurality of segments and a plurality of corners with each corner defined between adjacent segments. The presence of the plurality of corners induces separation of the rare cells from the other cells in the fluid sample as the rare cells move to a first equilibrium position within the at least one channel when a ratio of inertial lift forces (F) and Dean flow (F) of the fluid sample is from 2 to 10.

US Patent:

20150293010, Oct 15, 2015

Filed:

Oct 29, 2013

Appl. No.:

14/439429

Inventors:

- Ann Arbor MI, US
Hyeun Joong Yoon - Ann Arbor MI, US
Eric Lin - Ann Arbor MI, US
Max S. Wicha - Ann Arbor MI, US
Lianette Rivera Baez - Ann Arbor MI, US
Diane M. Simeone - Ann Arbor MI, US

International Classification:

G01N 15/10
B01L 3/00

Abstract:

A microfluidic device for detecting rare cells in a fluid sample comprises the rare cell and other cells. The microfluidic device comprises an inlet for receiving the fluid sample, a labyrinth channel structure in fluid communication with the inlet, and an outlet in fluid communication with the labyrinth channel structure for collecting the rare cells separated from the other cells in the fluid sample. The labyrinth channel structure comprises at least one channel through which the fluid sample flows. The at least one channel has a plurality of segments and a plurality of corners with each corner defined between adjacent segments. The presence of the plurality of corners induces separation of the rare cells from the other cells in the fluid sample as the rare cells move to a first equilibrium position within the at least one channel when a ratio of inertial lift forces (F) and Dean flow (F) of the fluid sample is from 2 to 10.