Eric W Moore

US Patent:

6734018, May 11, 2004

Filed:

Mar 17, 2000

Appl. No.:

09/528371

Inventors:

Lloyd Wolfinbarger, Jr. - Norfolk VA
Perry Lange - Virginia Beach VA
Alyce Linhurst - Virginia Beach VA
Eric Moore - Carrollton VA
Barry Nolf - Virginia Beach VA

Assignee:

Lifenet - Virginia Beach VA

International Classification:

C12N 500

US Classification:

435378

Abstract:

The invention provides methodologies and apparatus for producing acellular soft-tissue implants, both in small quantities and in commercializable quantities. Such soft-tissue implants include vascular graft substitutes. An acellular graft is produced by subjecting the tissue sample to an induced pressure mediated flow of an extracting solution, followed by inducing a pressure mediated flow of a treating solution, then washing the treated tissue to produce the acellular graft. The acellular grafts produced are uniform and non-immunogenic. The inventive method allows for the production of multiple decellularized soft tissue implants, where processing time is significantly less than prior art processes and the number of implants produced per day is increased over prior art processes. In clinical use, the decellularized grafts produced exhibit significantly improved in long-term durability and function.

US Patent:

7338757, Mar 4, 2008

Filed:

Jul 23, 2003

Appl. No.:

10/624534

Inventors:

Lloyd Wolfinbarger, Jr. - Norfolk VA, US
Perry Lange - Virginia Beach VA, US
Alyce Linhurst Jones - Virginia Beach VA, US
Eric Moore - Carrollton VA, US
Barry Nolf - Virginia Beach VA, US

Assignee:

Lifenet Health - Virginia Beach VA

International Classification:

A01N 1/00
C12N 5/00

US Classification:

435 11, 435378

Abstract:

The invention provides methodologies and apparatus for producing acellular soft-tissue implants, both in small quantities and in commercializable quantities. Such soft-tissue implants include vascular graft substitutes. An acellular graft is produced by subjecting the tissue sample to an induced pressure mediated flow of an extracting solution, followed by inducing a pressure mediated flow of a treating solution, then washing the treated tissue to produce the acellular graft. The acellular grafts produced are uniform and non-immunogenic. The inventive method allows for the production of multiple decellularized soft tissue implants, where processing time is significantly less than prior art processes and the number of implants produced per day is increased over prior art processes. In clinical use, the decellularized grafts produced exhibit significantly improved in long-term durability and function.

US Patent:

8563232, Oct 22, 2013

Filed:

Oct 28, 2003

Appl. No.:

10/694190

Inventors:

Lloyd Wolfinbarger, Jr. - Norfolk VA, US
Perry Lange - Virginia Beach VA, US
Eric Moore - Virginia Beach VA, US
Barry Nolf - Courtland VA, US

Assignee:

LifeNet Health - Virginia Beach VA

International Classification:

A01N 1/00

US Classification:

435 11, 435 12

Abstract:

The invention provides methodologies and apparatus for producing devitalized soft-tissue implants where the implant retains metabolically non-viable and/or reproductively non-viable cells, and preferably retains large molecular weight cytoplasmic proteins, such implants produced both in small quantities and in commercializable quantities. Such soft-tissue implants include vascular graft substitutes. A devitalized graft is produced by subjecting the tissue sample to an induced pressure mediated flow of an extracting solution, optionally followed by inducing a pressure mediated flow of a salt solution, then washing the tissue to produce the devitalized graft. The devitalized grafts produced are uniform and non-immunogenic. The inventive method allows for the production of multiple devitalized soft tissue implants, where processing time is significantly less than prior art processes and the number of implants produced per day is increased over prior art processes. In clinical use, the devitalized grafts produced exhibit significantly improved in long-term durability and function, and enhanced recellularization post-implantation.

US Patent:

8574826, Nov 5, 2013

Filed:

Oct 8, 2010

Appl. No.:

12/901135

Inventors:

Lloyd Wolfinbarger, Jr. - Norfolk VA, US
Perry Lange - Virginia Beach VA, US
Alyce Linthurst Jones - Virginia Beach VA, US
Eric Moore - Carrollton VA, US
Barry Nolf - Virginia Beach VA, US

Assignee:

LifeNet Health - Virginia Beach VA

International Classification:

A01N 1/00
C12N 5/00

US Classification:

435 11, 435378

Abstract:

The invention provides methodologies and apparatus for producing a cellular soft-tissue implants, both in small quantities and in commercializable quantities. Such soft-tissue implants include vascular graft substitutes. An acellular graft is produced by subjecting the tissue sample to an induced pressure mediated flow of an extracting solution, followed by inducing a pressure mediated flow of a treating solution, then washing the treated tissue to produce the acellular graft. The acellular grafts produced are uniform and nonimmunogenic. The inventive method allows for the production of multiple decellularized soft tissue implants, where processing time is significantly less than prior art processes and the number of implants produced per day is increased over prior art processes. In clinical use, the decellularized grafts produced exhibit significantly improved in long-term durability and function.

US Patent:

20090041729, Feb 12, 2009

Filed:

Mar 3, 2008

Appl. No.:

12/041435

Inventors:

Lloyd Wolfinbarger, JR. - Norforlk VA, US
Perry Lange - Virginia Beach VA, US
Alyce Linthurst Jones - Virginia Beach VA, US
Eric Moore - Virginia Beach VA, US
Barry Nolf - Courtland VA, US

Assignee:

LifeNet Health - Virginia Beach VA

International Classification:

A61K 35/12
A61P 43/00

US Classification:

424 937

Abstract:

The invention provides methodologies and apparatus for producing acellular soft-tissue implants, both in small quantities and in commercializable quantities. Such soft-tissue implants include vascular graft substitutes. An acellular graft is produced by subjecting the tissue sample to an induced pressure mediated flow of an extracting solution, followed by inducing a pressure mediated flow of a treating solution, then washing the treated tissue to produce the acellular graft. The acellular grafts produced are uniform and non-immunogenic. The inventive method allows for the production of multiple decellularized soft tissue implants, where processing time is significantly less than prior art processes and the number of implants produced per day is increased over prior art processes. In clinical use, the decellularized grafts produced exhibit significantly improved in long-term durability and function.

US Patent:

20140065238, Mar 6, 2014

Filed:

Oct 31, 2013

Appl. No.:

14/068308

Inventors:

Peny Lange - Virginia Beach VA, US
Eric Moore - Virginia Beach VA, US
Barry Naif - Courtland VA, US

Assignee:

LifeNet Health - Virginia Beach VA

International Classification:

A61L 27/36

US Classification:

424548, 424569, 424570, 424574, 435270, 424572

Abstract:

The invention provides methodologies and apparatus for producing acellular soft-tissue implants, both in small quantities and in commercializable quantities. Such soft-tissue implants include vascular graft substitutes. An acellular graft is produced by subjecting the tissue sample to an induced pressure mediated flow of an extracting solution, followed by inducing a pressure mediated flow of a treating solution, then washing the treated tissue to produce the acellular graft. The acellular grafts produced are uniform and nonimmunogenic.The inventive method allows for the production of multiple decellularized soft tissue implants, where processing time is significantly less than prior art processes and the number of implants produced per day is increased over prior art processes. In clinical use, the decellularized grafts produced exhibit significantly improved in long-tem durability and function.

US Patent:

20220202556, Jun 30, 2022

Filed:

Mar 15, 2022

Appl. No.:

17/695170

Inventors:

- Virginia Beach VA, US
Jason B. Schulte - Virginia Beach VA, US
Eric Moore - Virginia Beach VA, US
Perry L. Lange - Virginia Beach VA, US
Rex Nagao - Virginia Beach VA, US

Assignee:

LifeNet Health - Virginia Beach VA

International Classification:

A61F 2/06

Abstract:

The present invention provides a package comprising an aortoiliac artery graft and a record of a measured pressurized diameter of the aortoiliac artery graft, which measurement has been determined ex vivo under a pressure. A method of processing an aortoiliac artery graft is also provided. The processing method comprises subjecting an aortoiliac artery to a pressure ex vivo, and determining a measured pressurized diameter of the aortoiliac artery under the pressure. A method of treating abdominal aortic aneurysm, infected aortoiliac endograft or a traumatically damaged abdominal aorta or an iliac artery in a patient is further provided. The treatment method comprises anastomosing a processed aortoiliac artery graft with an aorta of the patient on the proximal end and the iliac or femoral arteries on the distal end, wherein a measured pressurized diameter of the processed aortoiliac artery graft has been determined ex vivo under a pressure.

US Patent:

20210330444, Oct 28, 2021

Filed:

Sep 19, 2018

Appl. No.:

16/329898

Inventors:

- Virginia Beach VA, US
Jason B. SCHULTE - Virginia Beach VA, US
Eric MOORE - Virginia Beach VA, US
Perry L. LANGE - Virginia Beach VA, US
Rex NAGAO - Virginia Beach VA, US

Assignee:

LifeNet Health - Virginia Beach VA

International Classification:

A61F 2/06

Abstract:

The present invention provides a package comprising an aortoiliac artery graft and a record of a measured pressurized diameter of the aortoiliac artery graft, which measurement has been determined ex vivo under a pressure. A method of processing an aortoiliac artery graft is also provided. The processing method comprises subjecting an aortoiliac artery to a pressure ex vivo, and determining a measured pressurized diameter of the aortoiliac artery under the pressure. A method of treating abdominal aortic aneurysm, infected aortoiliac endograft or a traumatically damaged abdominal aorta or an iliac artery in a patient is further provided. The treatment method comprises anastomosing a processed aortoiliac artery graft with an aorta of the patient on the proximal end and the iliac or femoral arteries on the distal end, wherein a measured pressurized diameter of the processed aortoiliac artery graft has been determined ex vivo under a pressure.