Eric A Nauman

US Patent:

20100290996, Nov 18, 2010

Filed:

Sep 10, 2008

Appl. No.:

12/676209

Inventors:

Cheryl A. Nickerson - Phoenix AZ, US
James W. Wilson - Wilmington DE, US
Mark C. Ott - Houston TX, US
Eric A. Nauman - West Lafayette IN, US
Michael J. Schurr - Aurora CO, US
Shameema Sarker - Chandler AZ, US

Assignee:

Arizona Board of Regents, for and on behalf of Arizona State University - Tempe AZ

International Classification:

A61K 49/00
A61K 39/112
C12Q 1/68
G01N 33/53
C12Q 1/02
C12Q 1/18
C12N 1/20
C12N 1/18
C12N 1/16
C40B 30/04

US Classification:

424 92, 4242351, 435 6, 435 71, 435 29, 435 32, 4352528, 4352533, 4352534, 4352552, 43525521, 4352554, 506 9

Abstract:

This invention is directed to applying a low sedimental fluid shear environment to manipulate microorganisms, and to microorganisms and compositions obtained based on such manipulation. Specifically, the present invention provides methods of modifying a molecular genetic or phenotypic characteristic (e.g., virulence, stress resistance or biofilm formation) of a microorganism by culturing in a low sedimental shear environment. One or more ion concentrations in the culture can be modulated in order to inhibit or amplify the extent of the modification. The present invention also provides microorganisms obtained from a low sedimental shear culture, which exhibit modified and desirable phenotypic characteristics, as well as therapeutic, vaccine and bioindustrial products prepared from such microorganisms. Further, the present invention provides methods for identifying molecules that modulate responses of a microorganism to a low sedimental shear environment and for determining the relevance of such molecules to pathogenenicity of the microorganism.

US Patent:

20110066241, Mar 17, 2011

Filed:

Sep 12, 2008

Appl. No.:

12/677499

Inventors:

Eric A. Nauman - West Lafayette IN, US
Darryl A. Dickerson - West Lafayette IN, US

Assignee:

Purdue Research Foundation - West Lafayette IN

International Classification:

A61F 2/08

US Classification:

623 1311, 523115

Abstract:

The present invention provides a cancellous bone scaffold to use in the replacement or repair of connective tissue such as ligaments and tendons. The cancellous bone scaffold has a fully demineralized segment with at least one adjacent mineralized end segment.

US Patent:

20120083688, Apr 5, 2012

Filed:

Oct 3, 2011

Appl. No.:

13/252183

Inventors:

Eric A. Nauman - West Lafayette IN, US
Evan Breedlove - Lafayette IN, US
Meghan Robinson - Lafayette IN, US
Katherine E. Morigaki - West Lafayette IN, US
Anne Zakrajsek - Lafayette OH, US
Larry Leverenz - West Lafayette IN, US
Tom Talavage - West Lafayette IN, US

Assignee:

PURDUE RESEARCH FOUNDATION - West Lafayette IN

International Classification:

A61B 5/055

US Classification:

600419, 600410

Abstract:

Systems and methods for detecting the effects of concussion are disclosed. In various embodiments, fMRI or other live analysis technique captures data regarding the subject's brain activity while he or she is performing a task that exercises one or more particular functional centers. In some embodiments, post-collision activity is compared to baseline data, and the diagnosis operates as a function of the comparison. in other embodiments, post-collision activity is analyzed, such as by partitioning the activity data into regions of interest and calculating activity for one particular region in comparison with certain other, perhaps adjacent, regions.

US Patent:

20080257057, Oct 23, 2008

Filed:

Oct 1, 2007

Appl. No.:

11/906281

Inventors:

Jason A. Habeger - Belleville MI, US
Benny M. Hillberry - Sun City Center FL, US
Eric A. Nauman - West Lafayette IN, US
Wendy A. Kerr - Cincinnati OH, US
Megan M. Mauck - Boonville IN, US
Rita J. Michlitsch - Grand Haven MI, US
Haroun Soud Al-Mishwit - Brookfield WI, US
Andrew D. Schwinke - Vernon Hills IL, US
John G. Nolfi - Lafayette IN, US

International Classification:

G01N 3/32

US Classification:

73808

Abstract:

A device for fatigue testing an implantable medical device having a compression assembly and a first bending assembly. The compression assembly supports first and second portions of the implantable medical device so as to apply a compression force to the implantable medical device along a compression axis and at a compression angle. The first bending assembly is configured to apply a first bending force onto the implantable medical device to move the first portion of the implantable medical device about a first bending axis with respect to the second portion of the implantable medical device. The first bending assembly is coupled with the compression assembly such that the compression angle remains substantially constant regardless of the position of the first portion of the implantable medical device with respect to the second portion of the implantable medical device.

US Patent:

20210398679, Dec 23, 2021

Filed:

Jun 18, 2021

Appl. No.:

17/352046

Inventors:

- Evanston IL, US
- West Lafayette IN, US
Eric NAUMAN - West Lafayette IN, US
Tom TALAVAGE - West Lafayette IN, US
Nicole VIKE - Evanston IL, US

Assignee:

Northwestern University - Evanston IL
Purdue Research Foundation - West Lafayette IN

International Classification:

G16H 50/20
G16B 40/20
G16B 50/10
G16B 50/30
G16H 10/40
G16H 50/50

Abstract:

A method can apply permutation procedures to mediation and moderation tests of multiple hypotheses, while controlling the rate of false positives. The techniques presented here through a platform-independent tool can be applied to a variety of datasets in diverse and interdisciplinary fields, such as biology and medicine, where integration of multi-scale data is utilized to unmask disease diagnosis, prognosis, susceptibility/resilience, treatment optimization, and biopharmaceutical development for any brain-based, psychological, or medical illness. This platform allows for study of human illness where animal models are proving inadequate.

US Patent:

20210337890, Nov 4, 2021

Filed:

Apr 30, 2021

Appl. No.:

17/246109

Inventors:

- West Lafayette IN, US
Eric A. Nauman - West Lafayette IN, US
Kevin G. Mclver - Lafayette IN, US
Jacob McGough - Battle Ground IN, US
Sean Bucherl - Lafayette IN, US

International Classification:

A41D 13/015
A41D 13/05

Abstract:

Padding materials capable of use as or incorporation into protective products, and methods of producing such padding materials. The padding material includes a base and an array of raised unit cells that individually protrude from a surface of the base so that the unit cells are spaced apart from each other. The base and the unit cells are formed of a cured polymeric material that contains fine porosity, and a substrate formed of a textile or fabric material is embedded in the base and permeated by the cured polymeric material.

US Patent:

20210220116, Jul 22, 2021

Filed:

Apr 5, 2021

Appl. No.:

17/222719

Inventors:

- Madison NJ, US
Adam B. YANKE - Madison NJ, US
Adam W. MARTINEZ - Madison NJ, US
Kurt W. S. KLITZKE - Madison NJ, US
Travis E. ENTROP - Madison NJ, US
Dimitrios J. ANGELIS - Madison NJ, US
Eric A. NAUMAN - West Lafayette IN, US
Darryl A. DICKERSON - Miami FL, US

International Classification:

A61F 2/08
A61L 27/36
A61F 2/28

Abstract:

Connective tissue-to-bone interface scaffolds (e.g., ligament-to-bone interface scaffolds, tendon-to-bone interface scaffolds, etc.). These scaffolds may be a single integrated implant or may be a modular (e.g., two-part) implant system.

US Patent:

20210013531, Jan 14, 2021

Filed:

Sep 24, 2020

Appl. No.:

17/031202

Inventors:

- West Lafayette IN, US
Eric A. Nauman - West Lafayette IN, US
Michael J. Dziekan - Park Ridge IL, US
Bradford Thorne - West Lafayette IN, US

International Classification:

H01M 8/0606
H01M 16/00
H01M 8/0662
H01M 8/04082
H01M 10/0525
H01M 8/04746
F02M 35/10
F02M 35/104
F02M 21/02
B60L 50/70

Abstract:

Systems and methods for the production and use of both hydrogen and electricity. Embodiments of the disclosure include preparing processed hydrogen gas and regulated electricity from an energy source, and use of the gas and electricity in applications such as fuel cell electric vehicles and diesel supplementation.