Eric K Neumann

US Patent:

7865534, Jan 4, 2011

Filed:

Aug 20, 2003

Appl. No.:

10/644582

Inventors:

D. Navin Chandra - Framingham MA, US
Fatima Chandra, legal representative - Framingham MA, US
Dexter R. Pratt - Reading MA, US
Eric K. Neumann - Lexington MA, US
Keith O. Elliston - Sudbury MA, US
Justin Sun - Norwood MA, US
Ted M. Slater - Saline MI, US

Assignee:

Genstruct, Inc. - Cambridge MA

International Classification:

G06F 17/30

US Classification:

707805, 707798, 702 19, 702 20, 706 45

Abstract:

Method and system for managing and evaluating life science data. Life Science data is placed in a knowledge base, that may be used for a variety of analysis tasks. Creating a knowledge base from the life science data involves generating two or more nodes indicative of life science data, assigning to one or more pairs of nodes a representation descriptor that corresponds to a relationship between the nodes, and assembling the nodes and the relationship descriptor into a database, such that at least one of the nodes is joined to another node by a representation descriptor. In some embodiments, the representation descriptor includes a case frame that describes the relationships between elements of life science data.

US Patent:

8068987, Nov 29, 2011

Filed:

Aug 13, 2002

Appl. No.:

10/218880

Inventors:

Noubar B. Afeyan - Lexington MA, US
Jan van der Greef - Driebergen-Rijsenburg, NL
Frederick E. Regnier - W. Lafayette IN, US
Aram S. Adourian - Woburn MA, US
Eric K. Neumann - Lexington MA, US
Matej Oresic - Espoo, FI
Elwin Robbert Verheij - Zeist, NL

Assignee:

BG Medicine, Inc. - Waltham MA

International Classification:

G01N 33/48
G01N 33/50

US Classification:

702 19, 703 2, 703 11, 707706, 211 4112, 436173, 702 22

Abstract:

The present invention provides methods and systems for developing profiles of a biological system based on the discernment of similarities, differences, and/or correlations between biomolecular components of a plurality of biological samples. Preferably, the method comprises utilizing hierarchical multivariate analysis of spectrometric data at one or more levels of correlation.

US Patent:

20050170372, Aug 4, 2005

Filed:

Aug 20, 2004

Appl. No.:

10/922820

Inventors:

Noubar Afeyan - Lexington MA, US
Jan van der Greef - Driebergen-Rijsenburg, NL
Frederick Regnier - W. Lafayette IN, US
Aram Adourian - Woburn MA, US
Eric Neumann - Lexington MA, US
Matej Oresic - Espoo, FI
Elwin Verheij - Zeist, NL

International Classification:

C12Q001/68
G06F019/00
G01N033/48
G01N033/50
G01N033/00

US Classification:

435006000, 436086000, 702019000

Abstract:

Methods and systems are disclosed for developing profiles of a state of a biological system based on the discernment of similarities, differences, and/or correlations between a plurality of data sets that are derived from one or more biomolecular component types, one or more biological sample types, and/or one or more types of measurements.

US Patent:

20050273275, Dec 8, 2005

Filed:

May 31, 2005

Appl. No.:

11/141258

Inventors:

Noubar Afeyan - Lexington MA, US
Jan van der Greef - Driebergen-Rijsenburg, NL
Frederick Regnier - W. Lafayette IN, US
Aram Adourian - Woburn MA, US
Eric Neumann - Lexington MA, US
Matej Oresic - Espoo, FI
Elwin Verheij - Zeist, NL

International Classification:

G01N031/00

US Classification:

702022000

Abstract:

The present invention provides methods and systems for developing profiles of a biological system based on the discernment of similarities, differences, and/or correlations between biomolecular components, of a single biomolecular component type, of a plurality of biological samples. Preferably, the method comprises utilizing hierarchical multivariate analysis of spectrometric data at one or more levels of correlation.

US Patent:

20050283320, Dec 22, 2005

Filed:

May 31, 2005

Appl. No.:

11/141253

Inventors:

Noubar Afeyan - Lexington MA, US
Jan van der Greef - Driebergen-Rijsenburg, NL
Frederick Regnier - W. Lafayette IN, US
Aram Adourian - Woburn MA, US
Eric Neumann - Lexington MA, US
Matej Oresic - Espoo, FI
Elwin Verheij - Zeist, NL

International Classification:

G01N031/00

US Classification:

702022000

Abstract:

The present invention provides methods and systems for developing profiles of a biological system based on the discernment of similarities, differences, and/or correlations between biomolecular components, of a single biomolecular component type, of a plurality of biological samples. Preferably, the method comprises utilizing hierarchical multivariate analysis of spectrometric data at one or more levels of correlation.

US Patent:

20110010099, Jan 13, 2011

Filed:

Sep 19, 2006

Appl. No.:

11/992257

Inventors:

Aram S Adourian - Woburn MA, US
Matej Oresic - Espoo, FI
Doris Damian - Newton MA, US
Eric K. Neumann - Lexington MA, US
Thomas Plasterer - Marlborough MA, US
Ezra Jennings - Cambridge MA, US

International Classification:

G06F 19/00
G01N 33/48

US Classification:

702 19

Abstract:

The present teachings relate to gaining insight into biological states, e.g., disease states or drugged states, by gathering, integrating, and combining biomolecular data. More particularly, the present teachings relate to methods and systems for profiling a state of a biological system, finding accessible biomarkers representative of the state of a biological system, and deriving insights into the biochemistry of a biological system for therapeutic, diagnostic, prognostic and other purposes.

US Patent:

20110270893, Nov 3, 2011

Filed:

Dec 30, 2010

Appl. No.:

12/982651

Inventors:

D. Navin Chandra - Framingham MA, US
Dexter R. Pratt - Reading MA, US
Eric K. Neumann - Lexington MA, US
Keith O. Elliston - Gaithersburg MD, US
Justin Sun - Norwood MA, US
Ted M. Slater - Stow MA, US

Assignee:

SELVENTA, INC. (F/K/A GENSTRUCT, INC.) - Cambridge MA

International Classification:

G06F 17/30

US Classification:

707802, 707E17005, 707E17044

Abstract:

Method and system for managing and evaluating life science data. Life Science data is placed in a knowledge base, that may be used for a variety of analysis tasks. Creating a knowledge base from the life science data involves generating two or more nodes indicative of life science data, assigning to one or more pairs of nodes a representation descriptor that corresponds to a relationship between the nodes, and assembling the nodes and the relationship descriptor into a database, such that at least one of the nodes is joined to another node by a representation descriptor. In some embodiments, the representation descriptor includes a case frame that describes the relationships between elements of life science data.

US Patent:

20120131484, May 24, 2012

Filed:

Jun 21, 2011

Appl. No.:

13/165508

Inventors:

Eric K. Neumann - Bedford MA, US
Keith G. Boyce - Boston MA, US

International Classification:

G06F 3/048

US Classification:

715769, 715810

Abstract:

A computer-implemented display of semantically characterized information can include cohort indicators representing a group of one or more specified cohort parameters applied in such a way so as to filter a dataset comprising RDF structured data items. Each cohort indicator can be associated with a set of RDF structured semantic predicates. At least one selectable facet value indicator can be included that represents one or more specified value parameters each being associated with a RDF structured semantic object. The one or more specified value parameters can be applicable to the dataset in such a way so as to enable additional filtering and modification of one or more of the resulting cohort groups of information. A visual display of filtered information can be included which results from separately applying, against the dataset, each group of one or more specified cohort parameters represented by each cohort indicator.