Eric B Paulson

US Patent:

20100296714, Nov 25, 2010

Filed:

May 22, 2008

Appl. No.:

12/601241

Inventors:

Kathleen Schmainda - Elm Grove WI, US
Eric S. Paulson - Wauwatosa WI, US
Douglas E. Prah - Muskego WI, US

Assignee:

IMAGING BIOMETRICS, LLC - Elm Grove WI

International Classification:

G06K 9/00

US Classification:

382131

Abstract:

A magnetic resonance imaging (MRI) methodology is provided for simultaneous measurement of dynamic susceptibility contrast (DSC) MRI and dynamic contrast enhanced (DCE) MRI perfusion and permeability parameters using a combination of dual echo and spiral acquisition techniques with no contrast agent preload. T1 and T2/T2* leakage effects are eliminated, thereby permitting accurate measurement of blood volume, blood flow and vascular permeability which are used in evaluating tumor angiogenesis.

US Patent:

20100298692, Nov 25, 2010

Filed:

May 22, 2008

Appl. No.:

12/601247

Inventors:

Kathleen Schmainda - Elm Grove WI, US
Eric S. Paulson - Wauwatosa WI, US
Douglas E. Prah - Muskego WI, US

Assignee:

IMAGING BIOMETRICS, LLC - Elm Grove WI

International Classification:

A61B 5/055

US Classification:

600410

Abstract:

An improved method for detecting tumor cell invasion using diffusion times as short as two (2) msec incorporates diffusion weighing imaging techniques into a standard spin echo (SE) pulse sequence to minimize the effects of compartment boundary restrictions on diffusion values and corresponding MRI imaging data related to glioma invasion.

US Patent:

20180304099, Oct 25, 2018

Filed:

Jun 25, 2018

Appl. No.:

16/017625

Inventors:

- Milwaukee WI, US
Eric S. Paulson - Milwaukee WI, US
Ergun Ahunbay - Milwaukee WI, US
Vern Hart - Milwaukee WI, US

International Classification:

A61N 5/10
A61B 5/055
A61B 5/00
G06T 11/00
G06T 7/11
G06K 9/52
G06K 9/62
A61B 6/03
A61B 6/00
A61B 8/00
A61B 8/08

Abstract:

Systems and methods directed to adaptive radiotherapy planning are provided. In some aspects, provided system and method include producing synthetic images from magnetic resonance data using relaxometry maps. The method includes applying corrections to the data and generating relaxometry maps therefrom. In other aspects, a method for adapting a radiotherapy plan is provided. The method includes determining an objective function based on dose gradients from an initial dose distribution, and generating an optimized plan based on updated images, using aperture morphing and gradient maintenance algorithms without need for organ-at-risk contouring. In yet other aspects, a method for obtaining 4D MR imaging using a temporal reshuffling of data acquired during normal breathing, a method for deformable image registration using a sequentially applied semi-physical model regularization method for multimodality images, and a method to generate 4D plans using an aperture morphing algorithm based on 4D CT or 4D MR imaging are provided.

US Patent:

20170185072, Jun 29, 2017

Filed:

May 20, 2015

Appl. No.:

15/312844

Inventors:

- Milwaukee WI, US
Andrzej Jesmanowicz - Brookfield WI, US
James S. Hyde - Dousman WI, US
Eric S. Paulson - Jackson WI, US
Tugan L. Muftuler - Menomonee Falls WI, US
Daniel Shefchik - Milwaukee WI, US

International Classification:

G05B 19/4099
G01R 33/387
B33Y 50/00
B29C 67/00
B33Y 10/00
A61B 5/055
G01R 33/00

Abstract:

Systems and methods for designing and fabricating three-dimensional objects with precisely computed material compositions for use in enhancing electromagnetic fields for magnetic resonance imaging (“MRI”) are provided. As examples, the fabricated object can be designed to reduce magnetic field inhomogeneities in the main magnetic field of an MRI system, or to reduce inhomogeneities in a transmit radio frequency (“RF”) field (i.e., a Bfield). As examples, the object can be a shim; a housing or other part of an RF coil; a medical device, such as a surgical implant; or component used in a medical device, such as a housing for an implantable medical device.

US Patent:

20160310761, Oct 27, 2016

Filed:

Dec 30, 2014

Appl. No.:

15/108188

Inventors:

- Milwaukee WI, US
Eric S. Paulson - Milwaukee WI, US
Ergun Ahunbay - Milwakee WI, US
Vern Hart - Milwaukee WI, US

International Classification:

A61N 5/10
G06T 11/00
G06K 9/52
G06T 7/00
G06K 9/62

Abstract:

Systems and methods directed to adaptive radiotherapy planning are provided. In some aspects, provided system and method include producing synthetic images from magnetic resonance data using relaxometry maps. The method includes applying corrections to the data and generating relaxometry maps therefrom. In other aspects, a method for adapting a radiotherapy plan is provided. The method includes determining an objective function based on dose gradients from an initial dose distribution, and generating an optimized plan based on updated images, using aperture morphing and gradient maintenance algorithms without need for organ-at-risk contouring. In yet other aspects, a method for obtaining 4D MR imaging using a temporal reshuffling of data acquired during normal breathing, a method for deformable image registration using a sequentially applied semi-physical model regularization method for multimodality images, and a method to generate 4D plans using an aperture morphing algorithm based on 4D CT or 4D MR imaging are provided.