Eric R Stern

US Patent:

45004650, Feb 19, 1985

Filed:

Jun 28, 1982

Appl. No.:

6/392818

Inventors:

Alan R. Amundsen - Somerville NJ
Eric W. Stern - Mountainside NJ

Assignee:

Engelhard Corporation - Iselin NJ

International Classification:

C07F 1500

US Classification:

260429R

Abstract:

There are described platinum-polyhydroxylated amine compounds which exhibit anti-tumor activity in mammalian species. The products are highly soluble in aqueous solutions and they may be administered either orally or in parenteral form.

US Patent:

40767620, Feb 28, 1978

Filed:

Apr 29, 1977

Appl. No.:

5/792175

Inventors:

Miron Abramovici - Somerset NJ
Eric W. Stern - Mountainside NJ

Assignee:

Engelhard Minerals & Chemicals Corporation - Iselin NJ

International Classification:

C07C 914
C07C 700
C10G 2702

US Classification:

260676R

Abstract:

Non-paraffinic hydrocarbons, such as aromatic hydrocarbons, in a stream of paraffinic hydrocarbons are removed in an operation adaptable for continuous operation by contacting the paraffinic hydrocarbon stream with an oxidation system comprising an aqueous solution of hypochlorite, such as sodium hypochlorite, and a ruthenium species, such as ruthenium dioxide, as the oxidation catalyst. The ruthenium species is oxidized by the hypochlorite to a higher oxidation state with resulting selective oxidation of the non-paraffinic hydrocarbons to water-soluble compounds and/or CO. sub. 2. A stream of paraffinic hydrocarbons having a substantially reduced content of or substantially free of non-paraffinic hydrocarbons is recoverable and, if desired, a stream of recovered paraffinic hydrocarbons may be recycled for additional contact with the oxidation system. Also, the aqueous phase comprising the oxidation system, after separation from the treated paraffinic hydrocarbons, is recycled to contact additional paraffinic hydrocarbons to be treated and/or, from time to time, a portion is separated and treated to reduce the ruthenium species therein which is then recovered and recycled and to convert the hypochlorite in the aqueous phase to the corresponding chloride and for discharge, thereby avoiding build-up in the operation of conversion products, e. g. water-soluble oxygenation material derivable from the selective oxidation of the non-paraffinic hydrocarbons.

US Patent:

55211330, May 28, 1996

Filed:

Nov 29, 1994

Appl. No.:

8/348397

Inventors:

Gerald S. Koermer - Roseland NJ
John M. Macaoay - Linden NJ
Paul R. Suitch - Milledgeville GA
Eric W. Stern - Mountainside NJ

Assignee:

Engelhard Corporation - Iselin NJ

International Classification:

B01T 3508

US Classification:

502 9

Abstract:

This invention relates to microspheres produced by spray drying clay slurries and calcining the product to form attrition resistant microspheres. Phosphoric acid is injected in a neutral to mildly alkaline dispersed high solids kaolin slurry immediately before spray drying to improve properties of the microspheres.

US Patent:

44629982, Jul 31, 1984

Filed:

Nov 4, 1983

Appl. No.:

6/549017

Inventors:

Alan R. Amundsen - Somerville NJ
Eric W. Stern - Mountainside NJ

Assignee:

Engelhard Corporation - Iselin NJ

International Classification:

A61K 31555

US Classification:

424245

Abstract:

A pharmaceutical composition in which the active ingredient is an ascorbate complex of platinum (II) coordinated to ammonia, a monodentate amine ligand or a bidentate amine ligand as, for example, an alkylamine, an alkylenediamine or a cycloalkylamine. Said compositions are useful in the treatment of malignant tumors in animals. They may be administered orally or parenterally and they exhibit high solubility in water and low toxicity.

US Patent:

45059284, Mar 19, 1985

Filed:

Dec 18, 1981

Appl. No.:

6/332112

Inventors:

Alan R. Amundsen - Somerville NJ
Eric W. Stern - Mountainside NJ

Assignee:

Engelhard Corporation - Iselin NJ

International Classification:

A61K 3128

US Classification:

514492

Abstract:

A pharmaceutical composition having as the active ingredient a cis-platinum(II) amine lactate complex in which said amine is derived from ammonia or a monodentate or bidentrate amine ligand such as an alkylamine or alkylene diamine. Said compositions may be administered orally or parenterally and they exhibit pronounced activity against malignant animal tumor cells sensitive thereto.

US Patent:

45784906, Mar 25, 1986

Filed:

Aug 17, 1984

Appl. No.:

6/642235

Inventors:

Alan R. Amundsen - Somerville NJ
Eric W. Stern - Mountainside NJ

Assignee:

Engelhard Corporation - Iselin NJ

International Classification:

C07F 1500

US Classification:

556136

Abstract:

There are described ionic bis(dicarboxylato)palladate(II) products derived from aliphatic and aromatic dicarboxylic acids useful as anti-tumor agents in mammals. Certain of the compounds are novel.

US Patent:

44579268, Jul 3, 1984

Filed:

Dec 18, 1981

Appl. No.:

6/332111

Inventors:

Alan R. Amundsen - Somerville NJ
Eric W. Stern - Mountainside NJ

Assignee:

Engelhard Corporation - Iselin NJ

International Classification:

A61K 3155
C07D30732

US Classification:

424245

Abstract:

There are described ascorbate complexes of platinum(II) coordinated to ammonia, a monodentate amine ligand or a bidentate amine ligand as, for example, an alkylamine, an alkylenediamine or a cycloalkylamine. Said complexes are useful in the treatment of malignant tumors in animals and they are characterized by high solubility in water and low toxicity.

US Patent:

48393860, Jun 13, 1989

Filed:

Aug 12, 1987

Appl. No.:

7/085283

Inventors:

Alan R. Amundsen - Somerville NJ
Eric W. Stern - Mountainside NJ

Assignee:

Engelhard Corporation - Menlo Park NJ

International Classification:

A61K 3128

US Classification:

514492

Abstract:

There are described ionic bis(dicarboxylato)palladate(II) products derived from aliphatic and aromatic dicarboxylic acids useful in the treatment of malignant animal tumors sensitive thereto. Certain of the compounds are novel.