Eric Wasserman Stern

US Patent:

20100184104, Jul 22, 2010

Filed:

Aug 4, 2009

Appl. No.:

12/535396

Inventors:

Tarek M. FAHMY - New Haven CT, US
Eric D. Stern - New Haven CT, US
Mark A. Reed - Monroe CT, US
Aleksandar Vacic - New Haven CT, US

International Classification:

G01N 33/53
C12M 1/00

US Classification:

435 792, 4352871, 4352872

Abstract:

The present invention relates to a device and method for determining the presence of a specific compound in solution. The device includes a nanosensor having an electrically conducting pathway between at least a first and second contact. The device also includes a first receptor, suitable for binding a specific compound in the solution, attached to the nanosensor, and a second receptor also suitable for binding the specific compound while the specific compound is bound to the first receptor. The second receptor is attached to an enzyme added to the solution. When the solution having the second receptor is added to the device, and a second compound that is a substrate for the enzyme is subsequently added to the solution, a measured difference in an electrical property in the device before and after the application of the second compound is indicative of the presence of the specific compound in the solution.

US Patent:

20100297608, Nov 25, 2010

Filed:

Dec 6, 2007

Appl. No.:

12/517230

Inventors:

Eric D. Stern - New Haven CT, US
Tarek M. Fahmy - New Haven CT, US
Mark A. Reed - Monroe CT, US
Andrew Hamilton - Guilford CT, US
David A. Lavan - Hamden CT, US
James F. Klemic - New Haven CT, US
David A. Routenberg - New Haven CT, US

International Classification:

C12Q 1/70
H01L 29/772
H01L 21/302
C12Q 1/02
G01N 33/53
C12Q 1/68

US Classification:

435 5, 257253, 438689, 435 29, 435 71, 435 6, 257E29242, 257E21214

Abstract:

The systems and methods described herein include a sensor for suitable for sensing chemical and biological substances. The sensor comprises a semiconductor layer formed in or on a substrate and a channel having nano-scale dimensions formed in the semiconductor layer, where the structure creates an electrically conducting pathway between a first contact and a second contact on the semiconductor layer. In certain preferred embodiments, the nano-scale channel has a trapezoidal cross-section with an effective width and exposed lateral faces, where the effective width is selected to have same order of magnitude as a Debye length (L) of the semiconductor material of which the semiconductor layer is formed.

US Patent:

20120107954, May 3, 2012

Filed:

Aug 26, 2011

Appl. No.:

13/218846

Inventors:

Tarek M. Fahmy - New Haven CT, US
Eric D. Stern - Cambridge MA, US
Mark A. Reed - Monroe CT, US

International Classification:

G01N 33/566
G01N 33/543
G01N 30/00
B01D 43/00
B82Y 15/00

US Classification:

436501, 422 69, 422527, 436518, 977920, 977700

Abstract:

The present invention provides a microfluidic purification chip for capturing a biomarker from a physiological solution. The present invention also provides a method of capturing and releasing a biomarker, wherein the biomarker is originally in a physiological solution. The present invention further provides a method of pre-purifying and measuring the concentration of a biomarker in a physiological solution.

US Patent:

20160054315, Feb 25, 2016

Filed:

Jun 30, 2015

Appl. No.:

14/755615

Inventors:

- New Haven CT, US
Eric D. Stern - New Haven CT, US
Mark A. Reed - Monroe CT, US
Aleksandar Vacic - New Haven CT, US
James F. Klemic - Falls Church VA, US

International Classification:

G01N 33/543

Abstract:

The present invention relates to a device and method for determining the presence of a specific compound in solution. The device includes a nanosensor having an electrically conducting pathway between at least a first and second contact. The device also includes a first receptor, suitable for binding a specific compound in the solution, attached to the nanosensor, and a second receptor also suitable for binding the specific compound while the specific compound is bound to the first receptor. The second receptor is attached to an enzyme added to the solution. When the solution having the second receptor is added to the device, and a second compound that is a substrate for the enzyme is subsequently added to the solution, a measured difference in an electrical property in the device before and after the application of the second compound is indicative of the presence of the specific compound in the solution.