Ernest S Kim

US Patent:

7388195, Jun 17, 2008

Filed:

Sep 30, 2005

Appl. No.:

11/241747

Inventors:

Angela M. Zapata - Arlington MA, US
Ernest S. Kim - Cambridge MA, US
Priya Agrawal - Los Angeles CA, US
Melissa D. Krebs - Quincy MA, US
Cristina E. Davis - Berkeley CA, US

Assignee:

Charles Stark Draper Laboratory, Inc. - Cambridge MA

International Classification:

B01D 59/44
H01J 49/00

US Classification:

250288, 250282, 250426, 250293, 250287, 250286, 250281, 250283, 250324, 250423 R, 250290, 250292, 324464, 331126, 386 46, 386125

Abstract:

The invention provides an interface assembly for delivering an ionized analyte from an ionization apparatus into an ion mobility spectrometer. This allows analysis of biological and non-biological samples, even non-volatile solids, via differential mobility spectrometry, without fragmentation of molecules. The invention also provides portable sample analysis systems that operate at ambient pressure. Systems of the invention may be used for high molecular weight species detection, for example, drinking water contaminants, pathogenic biological agents, bio-organic substances, non-biological material, peptides, proteins, oligonucleotides, polymers, bacteria, and hydrocarbons.

US Patent:

7968842, Jun 28, 2011

Filed:

May 16, 2008

Appl. No.:

12/122479

Inventors:

Angela M. Zapata - Arlington MA, US
Ernest S. Kim - Cambridge MA, US
Priya Agrawal - Los Angeles CA, US
Melissa D. Krebs - Quincy MA, US
Cristina E. Davis - Berkeley CA, US

Assignee:

The Charles Stark Draper Laboratory, Inc. - Cambridge MA

International Classification:

H01J 49/40

US Classification:

250288

Abstract:

The invention provides an interface assembly for delivering an ionized analyte from an ionization apparatus into an ion mobility spectrometer. This allows analysis of biological and non-biological samples, even non-volatile solids, via differential mobility spectrometry, without fragmentation of molecules. The invention also provides portable sample analysis systems that operate at ambient pressure. Systems of the invention may be used for high molecular weight species detection, for example, drinking water contaminants, pathogenic biological agents, bio-organic substances, non-biological material, peptides, proteins, oligonucleotides, polymers, bacteria, and hydrocarbons.

US Patent:

20090234332, Sep 17, 2009

Filed:

Mar 5, 2009

Appl. No.:

12/398311

Inventors:

Jeffrey T. Borenstein - Newton MA, US
James C. Hsiao - Watertown MA, US
Mark E. Keegan - Littleton MA, US
Ernest S. Kim - Cambridge MA, US

Assignee:

The Charles Stark Draper Laboratory, Inc - Cambridge MA

International Classification:

A61M 37/00
B29C 33/38
C12Q 1/02

US Classification:

6048911, 264220, 435 29

Abstract:

Artificial microvascular devices may include a polymer scaffold that defines a channel with a distensible wall.

US Patent:

20100323916, Dec 23, 2010

Filed:

Jan 14, 2010

Appl. No.:

12/687717

Inventors:

Guillermo Garcia-Cardena - Cambridge MA, US
Peter Mack - Chapel Hill NC, US
Jeffrey T. Borenstein - Newton MA, US
Ahmad S. Khalil - Brookline MA, US
Eli J. Weinberg - Needham MA, US
Jason O. Fiering - Boston MA, US
Ernest S. Kim - Cambridge MA, US

International Classification:

C40B 30/06
C40B 60/12

US Classification:

506 10, 506 39

Abstract:

In one embodiment, a high-throughput flow system includes an array of wells and a separate mechanical tip positioned within each well. Each mechanical tip is separately actuated to impart a shear stress pattern.

US Patent:

20130053823, Feb 28, 2013

Filed:

Feb 2, 2012

Appl. No.:

13/364583

Inventors:

Jason O. Fiering - Boston MA, US
Mark J. Mescher - West Newton MA, US
Erin E. Pararas - Swampscott MA, US
Jeffrey T. Borenstein - Newton MA, US
William F. Sewell - Sherborn MA, US
Sharon G. Kujawa - Bedford MA, US
Michael J. McKenna - Southborough MA, US
Ernest S. Kim - Cambridge MA, US

International Classification:

A61M 31/00

US Classification:

604514, 604264, 604246, 604151, 604247

Abstract:

An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a bodily cavity of a patient over a period of time includes a drug supply reservoir to supply drug into a delivery channel and an actuator for delivering the drug to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear. The drug is loaded into the delivery channel while producing substantially negligible flow at an outlet of the delivery channel.

US Patent:

20130144266, Jun 6, 2013

Filed:

Dec 5, 2012

Appl. No.:

13/705795

Inventors:

The Charles Stark Draper Laboratory, Inc. - Cambridge MA, US
Joseph L. Charest - Cambridge MA, US
James C. Hsiao - Watertown MA, US
Tatiana Kniazeva - Boston MA, US
Ernest S. Kim - Cambridge MA, US
Alla Epshteyn - Brookline MA, US
Vijaya Kolachalama - Cambridge MA, US

Assignee:

The Charles Stark Draper Laboratory, Inc. - Cambridge MA

International Classification:

A61M 1/16

US Classification:

604522, 422 48, 435 2

Abstract:

A device and method for oxygenating blood is disclosed herein. The device includes a plurality of passive mixing elements that causes a fluid to mix as it flows through the device. The passive mixing elements continually expose new red blood cells to the portion of the flow channel where oxygenation can occur. Accordingly, in some implementations, the device and method uses less blood to prime the device and allows for the oxygenation of blood with a substantial shorter flow channel when compared to conventional oxygenation methods and devices.

US Patent:

20140061115, Mar 6, 2014

Filed:

Sep 5, 2012

Appl. No.:

13/604256

Inventors:

Christopher DiBiasio - Stoughton MA, US
Joe Charest - Cambridge MA, US
Jeff Borenstein - Newton Upper Falls MA, US
Ernest Kim - Cambridge MA, US
Daniel Harjes - Acton MA, US

International Classification:

A61M 1/34
F17D 1/00

US Classification:

21032172, 137544

Abstract:

An compact hydraulic manifold for transporting shear sensitive fluids is provided. A channel network can include a trunk and branch architecture coupled to a bifurcation architecture. Features such as tapered channel walls, curvatures and angles of channels, and zones of low fluid pressure can be used to reduce the size while maintaining wall shear rates within a narrow range. A hydraulic manifold can be coupled to a series of microfluidic layers to construct a compact microfluidic device.

US Patent:

20210154379, May 27, 2021

Filed:

Nov 20, 2020

Appl. No.:

17/100309

Inventors:

- Cambridge MA, US
Ernest Kim - Cambridge MA, US
Jeffrey Borenstein - West Roxbury MA, US

International Classification:

A61M 1/00
A61M 39/24

Abstract:

The present disclosure provides a handpiece for trans-canal delivery of a therapeutic substance to the inner ear. The handpiece can be inserted into the middle ear via a surgical tympanotomy approach. The handpiece can be integrated with a micropump and a fluid reservoir. The handpiece can enable a controlled injection of a therapeutic substance directly through the round window membrane and into the inner ear. The direct delivery of the therapeutic substance to the inner ear can enable the delivery of a precise amount of therapeutic substance into the inner ear. The micropump can include a self-contained fluid reservoir that can provide predetermined volumes of fluid to precise areas of the patient.