Ernest Jamarre Lee

US Patent:

20040228915, Nov 18, 2004

Filed:

Apr 2, 2004

Appl. No.:

10/816699

Inventors:

Robert Noack - Ann Arbor MI, US
John Heimlich - Portage MI, US
Ernest Lee - Kalamazoo MI, US

International Classification:

A61K031/704
A61K009/26
A61K009/24

US Classification:

424/471000, 514/035000

Abstract:

The present invention is directed to an extended release multiparticulate formulation of a therapeutic agent, wherein coated core multiparticulate particles of the therapeutic agent are overcoated with a binder-dispersing agent, such as povidone or cross-povidone. The invention is also directed to compressed tablets of the extended release multiparticulate formulation of the invention, and to a method of oral administration of compressed tablets of clindamycin to a subject to treat or prevent a gram-positive bacterial infection therein. The binder-dispersing agent in the formulations of the present invention ensure that compressed tablets formed therefrom will remain intact through oral administration, and dissolve shortly thereafter, enabling the multiparticulates to release the therapeutic agent contained therein over an extended period of time.