Thomas F. Egan - Houston TX, US Ernest K. Lewis - Pearland TX, US Kelley L. Waters - Houston TX, US
Assignee:
Ionwerks, Inc. - Houston TX
International Classification:
H01J 49/00
US Classification:
250287
Abstract:
The present invention relates to a method and apparatus for ionizing a neutral MALDI desorption plume, and in particular, for efficiently measuring the ionized MALDI desorption plume when post-ionization techniques are combined with a medium pressure MALDI-IM-oTOFMS instrument. Additionally, the present disclosure provides a method and apparatus that simultaneously separates tissue-sample MALDI ions by IM-oTOFMS according to their chemical family. After separation, the MALDI ions are directly compared to the ions created by post-ionizing the co-desorbed neutral molecules with a second laser wherein the second laser is delayed by a few hundred microseconds. The present disclosure further provides novel approaches that enhance the analysis of ions, including the use of giant fullerene internal standards to enhance mass accuracy, and ultraviolet (UV) declustering lasers to generate intact peptides and proteins, either of which may be followed by VUV post-ionization which generates identifiable structural fragments.
Nonoparticulate Assisted Nanoscale Molecular Imaging By Mass Spectrometery
J. Albert Schultz - Houston TX, US Thomas F. Egan - Houston TX, US Ernest K. Lewis - Pearland TX, US Steven Ulrich - Houston TX, US Kelley L. Waters - Houston TX, US
Assignee:
Ionwerks, Inc. - Houston TX
International Classification:
H01J 49/40 H01J 49/26 H01J 37/26 G01N 21/64
US Classification:
250281, 250282, 250287, 250285
Abstract:
Methods and devices for mass spectrometry are described, specifically the use of nanoparticulate implantation as a matrix for secondary ion and more generally secondary particles. A photon beam source or a nanoparticulate beam source can be used a desorption source or a primary ion/primary particle source.
Post-Ionization Of Neutrals For Ion Mobility Otofms Identification Of Molecules And Elements Desorbed From Surfaces
J. Albert Schultz - Houston TX, US Thomas F. Egan - Houston TX, US Kelley L. Waters - Houston TX, US Ernest K. Lewis - Pearland TX, US
International Classification:
H01J 49/40 H01J 49/04 G12B 13/00
US Classification:
2502521, 250287, 250282
Abstract:
The present invention relates to a method and apparatus for ionizing a neutral MALDI desorption plume, and in particular, for efficiently measuring the ionized MALDI desorption plume when post-ionization techniques are combined with a medium pressure MALDI-IM-oTOFMS instrument. Additionally, the present disclosure provides a method and apparatus that simultaneously separates tissue-sample MALDI ions by IM-oTOFMS according to their chemical family. After separation, the MALDI ions are directly compared to the ions created by post-ionizing the co-desorbed neutral molecules with a second laser wherein the second laser is delayed by a few hundred microseconds. The present disclosure further provides novel approaches that enhance the analysis of ions, including the use of giant fullerene internal standards to enhance mass accuracy, and ultraviolet (UV) declustering lasers to generate intact peptides and proteins, either of which may be followed by VUV post-ionization which generates identifiable structural fragments.
Nanoparticulate Assisted Nanoscale Molecular Imaging By Mass Spectrometry
Methods and devices for mass spectrometry are described, specifically the use of nanoparticulate implantation as a matrix for secondary ion and more generally secondary particles. A photon beam source or a nanoparticulate beam source can be used a desorption source or a primary ion/primary particle source.
Nanoparticulate Assisted Nanoscale Molecular Imaging By Mass Spectrometry
Methods and devices for mass spectrometry are described, specifically the use of nanoparticulate implantation as a matrix for secondary ion and more generally secondary particles. A photon beam source or a nanoparticulate beam source can be used a desorption source or a primary ion/primary particle source.
Nanoparticulate Assisted Nanoscale Molecular Imaging By Mass Spectrometry
Methods and devices for mass spectrometry are described, specifically the use of nanoparticulate implantation as a matrix for secondary ion and more generally secondary particles. A photon beam source or a nanoparticulate beam source can be used a desorption source or a primary ion/primary particle source.
Nanoparticulate Assisted Nanoscale Molecular Imaging By Mass Spectrometry
- Houston TX, US Thomas F. Egan - Houston TX, US Ernest K. Lewis - Pearland TX, US Steven Ulrich - Houston TX, US Kelley L. Waters - Houston TX, US
Assignee:
Ionwerks, Inc. - Houston TX
International Classification:
H01J 49/10 G01N 21/64 G01N 21/65 H01J 49/04
Abstract:
Methods and devices for mass spectrometry are described, specifically the use of nanoparticulate implantation as a matrix for secondary ion and more generally secondary particles. A photon beam source or a nanoparticulate beam source can be used a desorption source or a primary ion/primary particle source.
Nanoparticulate Assisted Nanoscale Molecular Imaging By Mass Spectrometry
- Houston TX, US Thomas F. Egan - Houston TX, US Ernest K. Lewis - Pearland TX, US Steven Ulrich - Houston TX, US Kelley L. Waters - Houston TX, US
International Classification:
H01J 49/00 H01J 49/14
Abstract:
Methods and devices for mass spectrometry are described, specifically the use of nanoparticulate implantation as a matrix for secondary ion and more generally secondary particles. A photon beam source or a nanoparticulate beam source can be used a desorption source or a primary ion/primary particle source.
Planz Elementary School Bakersfield CA 1968-1972, Greenfield Junior High School Bakersfield CA 1972-1974, Bakersfield Adult School Bakersfield CA 1977-1977