Ernest K Wong

US Patent:

20110033528, Feb 10, 2011

Filed:

Aug 5, 2009

Appl. No.:

12/536335

Inventors:

Alistair J. Leigh - Seattle WA, US
Christopher A. Procyshyn - Surrey, CA
Ernest S.Y. Wong - Superior CO, US
Christen M. Giandomenico - Blaine WA, US

Assignee:

Poniard Pharmaceuticals, Inc. - Seattle WA

International Classification:

A61K 31/555
A61K 9/28
A61K 9/48
A61P 35/00

US Classification:

424456, 514188, 424474, 424451, 424478, 424480, 424482

Abstract:

The invention provides an oral dosage form for the anti-cancer drug picoplatin comprising a core and a coating, the dosage form being free of redox-active metal salts. The core of the tablet is a substantially dry powder comprising about 10 to 60 wt % picoplatin wherein the picoplatin is a particulate of less than about 10 microns average particle diameter, about 40-80 wt % of a filler comprising a substantially water-soluble, water-dispersible, or water-absorbing carbohydrate, and an effective amount of up to about 5 wt % of a lubricant. The dosage form can further include a dispersant.

US Patent:

20130183433, Jul 18, 2013

Filed:

Aug 16, 2012

Appl. No.:

13/587711

Inventors:

Alistair J. Leigh - Seattle WA, US
Christopher A. Procyshyn - Surrey, CA
Ernest S.Y. Wong - Superior CO, US
Christen M. Giandomenico - Blaine WA, US

Assignee:

Poniard Pharmaceuticals, Inc. - Seattle WA

International Classification:

A61J 3/00

US Classification:

427 214

Abstract:

The invention provides an oral dosage form for the anti-cancer drug picoplatin comprising a core and a coating, the dosage form being free of redox- active metal salts. The core of the tablet is a substantially dry powder comprising about 10 to 60 wt % picoplatin wherein the pieoplatin is a particulate of less than about 10 microns average particle diameter, about 40-80 wt % of a filler comprising a substantially water-soluble, water-dispersible, or water-absorbing carbohydrate, and an effective amount of up to about 5 wt % of a lubricant. The dosage form can further include a dispersant.