Eugene A Levin

US Patent:

7241586, Jul 10, 2007

Filed:

Feb 17, 2005

Appl. No.:

11/060255

Inventors:

Poonam S. Gulati - La Canada CA, US
Sarnath Chattaraj - Simi Valley CA, US
Elango S. Minnoor - Northridge CA, US
Eugene Levin - West Hills CA, US
Xiao Zhu - Valencia CA, US
William P. Van Antwerp - Valencia CA, US

Assignee:

Medtronic MiniMed, Inc. - Northridge CA

International Classification:

C12Q 1/26

US Classification:

435 25

Abstract:

Embodiments of the invention include polypeptide formulations and methods for making, using and characterizing them. Embodiment of the invention include stabilized polypeptide formulations, for example stable glucose oxidase formulations that can be used with glucose sensors used in the management of diabetes. Another embodiment of the invention includes methods to characterize the concentration of nonionic surfactants in stabilized polypeptide formulation for example stable insulin formulations that can be used in the treatment of diabetes.

US Patent:

7432243, Oct 7, 2008

Filed:

Apr 7, 2003

Appl. No.:

10/408415

Inventors:

Eugene G. Levin - San Diego CA, US

Assignee:

The Scripps Research Institute - La Jolla CA

International Classification:

A61K 38/18
C07K 17/00
C07K 14/50
C07K 19/00

US Classification:

514 12, 530324, 930280

Abstract:

The invention relates to fragments of an amino acid sequence of mature, full length 24 kDa fibroblast growth factor-2 or an analog thereof. The fragments have an activity that inhibits the migration of cultured cells as well as inhibiting angiogenesis, tumor growth, or any other processes that involve the migration of cells in vivo. This fragment does not stimulate the proliferation of cells which is in contrast to activity shown by the mature, full-length 24 kDa fibroblast growth factor-2. The present invention also relates to a DNA molecule encoding the fragment, an expression vector and a transformed host containing the DNA molecule, and a method of producing the protein by culturing the transformed host. Moreover, the present invention relates to a therapeutic composition the 24 kDa fibroblast growth factor fragment and a pharmaceutically acceptable carrier.

US Patent:

7462035, Dec 9, 2008

Filed:

Jul 27, 2005

Appl. No.:

11/190697

Inventors:

Kang Lee - Woodland Hills CA, US
Thomas Forrester - Westminster CA, US
Tomasz Jannson - Torrance CA, US
Andrew Kostrzewski - Garden Grove CA, US
Eugene Levin - Los Angeles CA, US
Gajendra Savant - Rolling Hills Estates CA, US

Assignee:

Physical Optics Corporation - Torrance CA

International Classification:

H01R 33/00

US Classification:

439 37, 439121

Abstract:

An entirely wearable electrical connector for power/data connectivity. The principal element of a modular network is the wearable electrical connector, which is integrated into a personal area network with USB compatibility. Several wearable connector embodiments are disclosed. The first, an O-ring based version, was subsequently replaced by a more mature second version, which is based on anisotropic pressure sensitive conductive elastomer. Both are snap-style, low-profile, 360-moving, round, blind operable plug-and-play, reconfigurable wearable connectors with power/data daisy-lattice-style connectivity. A third embodiment comprises a non-conductive elastomeric environmental seal. A fourth embodiment utilizes a self-acting, automatic shutter-type environmental seal. A fifth embodiment comprises a smaller version that resembles a conventional snap fastener commonly used on clothing. The inventive technology will benefit the military and public safety personnel such as police, fire, EMT and other services that require special protective clothing integrated with multiple electronic devices.

US Patent:

7556532, Jul 7, 2009

Filed:

Dec 21, 2006

Appl. No.:

11/644149

Inventors:

Kang Lee - Woodland Hills CA, US
Thomas Forrester - Westminster CA, US
Tomasz Jannson - Torrance CA, US
Andrew Kostrzewski - Garden Grove CA, US
Eugene Levin - Los Angeles CA, US
Gajendra Savant - Rolling Hills Estates CA, US

Assignee:

Physical Optics Corporation - Torrance CA

International Classification:

H01R 33/945

US Classification:

43962004, 43962022, 3405456

Abstract:

A carton-centric security system that uniquely combines a low-cost version of the rugged connector technology and a novel smart skin is provided. The carton-centric security system includes RF electronics for communication. The system can fully meet the homeland security need to autonomously seal, secure, and monitor the integrity of shipping cartons/parcels below the ISO intermodal shipping container level. The system can seal the contents of a shipping carton within a “smart skin/wrapper,” which physically surrounds the contents, monitors the physical integrity of the shipping carton and detects any intrusion into the carton. In case of an intrusion, the system provides notification of the intrusion of the carton or tampering with the carton security system, including alteration of the carton contents, theft or unauthorized removal of the entire carton.

US Patent:

7629146, Dec 8, 2009

Filed:

Oct 6, 2006

Appl. No.:

11/544970

Inventors:

Eugene G. Levin - San Diego CA, US

Assignee:

The Scripps Research Institute - La Jolla CA

International Classification:

C12P 21/02
C12N 15/12
C12N 15/63
C12N 15/79
C12N 5/10
C12N 1/21
C07K 14/50

US Classification:

435 691, 4352523, 4353201, 435325, 536 235, 536 241, 530324

Abstract:

The invention relates to fragments of an amino acid sequence of mature, full length kDa fibroblast growth factor- or an analog thereof. The fragments have an activity that inhibits the migration of cultured cells as well as inhibiting angiogenesis, tumor growth, or any other processes that involve the migration of cells in vivo. This fragment does not stimulate the proliferation of cells which is in contrast to activity shown by the mature, full-length kDa fibroblast growth factor-. The present invention also relates to a DNA molecule encoding the fragment, an expression vector and a transformed host containing the DNA molecule, and a method of producing the protein by culturing the transformed host. Moreover, the present invention relates to a therapeutic composition the kDa fibroblast growth factor fragment and a pharmaceutically acceptable carrier.

US Patent:

7658612, Feb 9, 2010

Filed:

Nov 25, 2008

Appl. No.:

12/323360

Inventors:

Kang Lee - Woodland Hills CA, US
Thomas Forrester - Hacienda Heights CA, US
Tomasz Jannson - Torrance CA, US
Andrew Kostrzewski - Garden Grove CA, US
Eugene Levin - Los Angeles CA, US
Gajendra Savant - Rolling Hills Estates CA, US

Assignee:

Physical Optics Corporation - Torrance CA

International Classification:

H01R 33/00

US Classification:

439 37, 439 761

Abstract:

An entirely wearable electrical connector for power/data connectivity. The principal element of a modular network is the wearable electrical connector, which is integrated into a personal area network with USB compatibility.

US Patent:

7687268, Mar 30, 2010

Filed:

Jul 25, 2007

Appl. No.:

11/881074

Inventors:

Sarnath Chattaraj - Simi Valley CA, US
Elango S. Minnoor - Northridge CA, US
Eugene Levin - West Hills CA, US
Poonam S. Gulati - La Canada CA, US
John Pennala - Newhall CA, US

Assignee:

Medtronic MiniMed, Inc. - Northridge CA

International Classification:

G01N 33/00
G01N 33/15

US Classification:

436 34, 436 2

Abstract:

Embodiments of the invention provide to apparatuses and media used in drug elution studies and methods for making and using them. Such methods and materials can be used for example to assess and control the manufacturing process variability of drug eluting implantable devices such as cardiac leads. One embodiment of the invention is a drug elution method that can be used for in-vitro studies of a matrix impregnated with a compound such as a drug blended polymer matrix. A related embodiment of the invention is an apparatus that is used for example to facilitate the practice of the above-noted methods by inhibiting the evaporation of dissolution media from the vessels in which elution is observed.

US Patent:

7731517, Jun 8, 2010

Filed:

Nov 25, 2008

Appl. No.:

12/323321

Inventors:

Kang Lee - Woodland Hills CA, US
Thomas Forrester - Hacienda Heights CA, US
Tomasz Jannson - Torrance CA, US
Andrew Kostrzewski - Garden Grove CA, US
Eugene Levin - Houghton MI, US
Gajendra Savant - Rolling Hills Estates CA, US

Assignee:

Physical Optics Corporation - Torrance CA

International Classification:

H01R 13/52

US Classification:

439271, 439 5, 439589

Abstract:

An entirely wearable electrical connector for power/data connectivity. The principal element of a modular network is the wearable electrical connector, which is integrated into a personal area network with USB compatibility. An embodiment comprises a non-conductive elastomeric environmental seal.