Eugene G Levin

US Patent:

7241586, Jul 10, 2007

Filed:

Feb 17, 2005

Appl. No.:

11/060255

Inventors:

Poonam S. Gulati - La Canada CA, US
Sarnath Chattaraj - Simi Valley CA, US
Elango S. Minnoor - Northridge CA, US
Eugene Levin - West Hills CA, US
Xiao Zhu - Valencia CA, US
William P. Van Antwerp - Valencia CA, US

Assignee:

Medtronic MiniMed, Inc. - Northridge CA

International Classification:

C12Q 1/26

US Classification:

435 25

Abstract:

Embodiments of the invention include polypeptide formulations and methods for making, using and characterizing them. Embodiment of the invention include stabilized polypeptide formulations, for example stable glucose oxidase formulations that can be used with glucose sensors used in the management of diabetes. Another embodiment of the invention includes methods to characterize the concentration of nonionic surfactants in stabilized polypeptide formulation for example stable insulin formulations that can be used in the treatment of diabetes.

US Patent:

7432243, Oct 7, 2008

Filed:

Apr 7, 2003

Appl. No.:

10/408415

Inventors:

Eugene G. Levin - San Diego CA, US

Assignee:

The Scripps Research Institute - La Jolla CA

International Classification:

A61K 38/18
C07K 17/00
C07K 14/50
C07K 19/00

US Classification:

514 12, 530324, 930280

Abstract:

The invention relates to fragments of an amino acid sequence of mature, full length 24 kDa fibroblast growth factor-2 or an analog thereof. The fragments have an activity that inhibits the migration of cultured cells as well as inhibiting angiogenesis, tumor growth, or any other processes that involve the migration of cells in vivo. This fragment does not stimulate the proliferation of cells which is in contrast to activity shown by the mature, full-length 24 kDa fibroblast growth factor-2. The present invention also relates to a DNA molecule encoding the fragment, an expression vector and a transformed host containing the DNA molecule, and a method of producing the protein by culturing the transformed host. Moreover, the present invention relates to a therapeutic composition the 24 kDa fibroblast growth factor fragment and a pharmaceutically acceptable carrier.

US Patent:

7629146, Dec 8, 2009

Filed:

Oct 6, 2006

Appl. No.:

11/544970

Inventors:

Eugene G. Levin - San Diego CA, US

Assignee:

The Scripps Research Institute - La Jolla CA

International Classification:

C12P 21/02
C12N 15/12
C12N 15/63
C12N 15/79
C12N 5/10
C12N 1/21
C07K 14/50

US Classification:

435 691, 4352523, 4353201, 435325, 536 235, 536 241, 530324

Abstract:

The invention relates to fragments of an amino acid sequence of mature, full length kDa fibroblast growth factor- or an analog thereof. The fragments have an activity that inhibits the migration of cultured cells as well as inhibiting angiogenesis, tumor growth, or any other processes that involve the migration of cells in vivo. This fragment does not stimulate the proliferation of cells which is in contrast to activity shown by the mature, full-length kDa fibroblast growth factor-. The present invention also relates to a DNA molecule encoding the fragment, an expression vector and a transformed host containing the DNA molecule, and a method of producing the protein by culturing the transformed host. Moreover, the present invention relates to a therapeutic composition the kDa fibroblast growth factor fragment and a pharmaceutically acceptable carrier.

US Patent:

7803772, Sep 28, 2010

Filed:

Oct 23, 2009

Appl. No.:

12/604577

Inventors:

Eugene G. Levin - San Diego CA, US

Assignee:

The Scripps Research Institute - La Jolla CA

International Classification:

A61K 38/18
C07K 14/50

US Classification:

514 12, 530300

Abstract:

The invention relates to fragments of an amino acid sequence of mature, full length 24 kDa fibroblast growth factor-2 or an analog thereof. The fragments have an activity that inhibits the migration of cultured cells as well as inhibiting angiogenesis, tumor growth, or any other processes that involve the migration of cells in vivo. This fragment does not stimulate the proliferation of cells which is in contrast to activity shown by the mature, full-length 24 kDa fibroblast growth factor-2. The present invention also relates to a DNA molecule encoding the fragment, an expression vector and a transformed host containing the DNA molecule, and a method of producing the protein by culturing the transformed host. Moreover, the present invention relates to a therapeutic composition the 24 kDa fibroblast growth factor fragment and a pharmaceutically acceptable carrier.

US Patent:

20070182762, Aug 9, 2007

Filed:

Feb 3, 2006

Appl. No.:

11/346766

Inventors:

Xiaqing Wu - Fountain Valley CA, US
Eugene Levin - Los Angeles CA, US
Geoffrey Wade - Laguna Niguel CA, US

International Classification:

G09G 5/00

US Classification:

345647000

Abstract:

A novel, easy to use, and computational efficient rubber sheeting algorithm is designed for interactive image registration in a web-based application environment. The algorithm has two steps, including a piece-wise linear interpolation step to interactively find a suitable set of control points and displacement vectors, and a following optional global radial basis wrap step to generate smoother result using the final control point set. A dynamic Delaunay triangulation method is designed to efficiently update the decomposition of the image. Natural and intuitive wrapping result will be dynamically generated in real-time while the user interactively insert, delete or drag a control point. The number of control points is not limited, and a large number of control points can be used if necessary without compromising the performance of the algorithm. With enough control points specified using the piece-wise rubber-sheeting step, the wrapping result can be further smoothed by using the optional, click-button poly-quadric global wrapping method in the second step. The algorithm is implemented as a Java Applet and able to run as a cross-platform web-based application.

US Patent:

20080113443, May 15, 2008

Filed:

May 25, 2007

Appl. No.:

11/807073

Inventors:

Poonam S. Gulati - La Canada CA, US
Sarnath Chattaraj - Simi Valley CA, US
Elango S. Minnoor - Northridge CA, US
Eugene Levin - West Hills CA, US
Xiao Zhu - Valencia CA, US
William P. Van Antwerp - Valencia CA, US

International Classification:

G01N 33/44
G01N 30/02

US Classification:

436 85, 436161

Abstract:

Embodiments of the invention include polypeptide formulations and methods for making, using and characterizing them. Embodiment of the invention include stabilized polypeptide formulations, for example stable glucose oxidase formulations that can be used with glucose sensors used in the management of diabetes. Another embodiment of the invention includes methods to characterize the concentration of nonionic surfactants in stabilized polypeptide formulation for example stable insulin formulations that can be used in the treatment of diabetes.