Eva M Mezey

US Patent:

7022321, Apr 4, 2006

Filed:

Apr 11, 2002

Appl. No.:

10/122703

Inventors:

Martin A. Eglitis - Indianapolis IN, US
Eva Mezey - Rockville MD, US
Mary Maral Mouradian - Bethesda MD, US

International Classification:

A01N 63/00
A01N 65/00
A61K 48/00

US Classification:

424 9321, 424 931, 424 932

Abstract:

The present disclosure relates to a method for introducing a hematopoietic cell into the brain of a mammal, by administering bone marrow-derived progenitor cells into the body of the mammal by intravenous injection. The bone marrow-derived cell is preferably a cell that differentiates into a glial cell. The disclosure also relates to a method for delivery of therapeutic protein molecules into the brain of a mammal, by administering to a mammal an effective amount of bone marrow-derived progenitor cells which contain a gene having a nucleic acid sequence that encodes a functional therapeutic protein. Isolated recombinant cells and a pharmaceutical composition are also provided.

US Patent:

20060134081, Jun 22, 2006

Filed:

Jan 25, 2006

Appl. No.:

11/340322

Inventors:

Martin Eglitis - Indianapolis IN, US
Eva Mezey - Rockville MD, US
Mary Mouradian - Bethesda MD, US

International Classification:

A61K 48/00
C12N 5/08
C12N 15/867

US Classification:

424093210, 435456000, 435372000

Abstract:

The present disclosure relates to a method for introducing a hematopoietic cell into the brain of a mammal, by administering bone marrow-derived progenitor cells into the body of the mammal by intravenous injection. The bone marrow-derived cell is preferably a cell that differentiates into a glial cell. The disclosure also relates to a method for delivery of therapeutic protein molecules into the brain of a mammal, by administering to a mammal an effective amount of bone marrow-derived progenitor cells which contain a gene having a nucleic acid sequence that encodes a functional therapeutic protein. Isolated recombinant cells and a pharmaceutical composition are also provided.

US Patent:

55523080, Sep 3, 1996

Filed:

Oct 24, 1991

Appl. No.:

7/782298

Inventors:

Beth J. Hoffman - Kensington MD
Eva Mezey - Rockville MD
Michael J. Brownstein - Rockville MD

Assignee:

The United States of America as represented by the Department of Health
and Human Services - Washington DC

International Classification:

C12N 1512

US Classification:

4351723

Abstract:

The invention described in this disclosure relates to a cloned cDNA encoding the serotonin transporter protein (5HTT) usually found in cells of part of the central nervous system, gut, adrenal gland and in platelets. The invention is further directed to the purified serotonin transporter protein and its use and immunogen for the production of anti-5HTT antibodies. The disclosure also discussses methods for use of the cDNA for diagnostic and treatment applications, and methods for use of permanent cell lines transformed with the serotonin transporter cDNA for pharmaceutical screening. The use of anti-5HTT antibodies as a diagnostic tool is also addressed.