Evan T Murray

US Patent:

20180356318, Dec 13, 2018

Filed:

Dec 2, 2016

Appl. No.:

15/780875

Inventors:

- Cambridge MA, US
Evan Murray - Cambridge MA, US
Jae Hun Cho - Cambridge MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

G01N 1/30
G01N 33/53
A01N 1/02

Abstract:

This disclosure provides methods for preserving samples such as tissue samples and rendering such preserved samples mechanically and chemically stable throughout repeated rounds of labeling and imaging for a plurality of targets.

US Patent:

20150285765, Oct 8, 2015

Filed:

Apr 3, 2015

Appl. No.:

14/678660

Inventors:

- Cambridge MA, US
Kimberly Ohn - Boston MA, US
Evan Murray - Cambridge MA, US
Jae Hun Cho - Cambridge MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

G01N 27/447

Abstract:

Articles and methods for the active transport of molecules into, within, and/or from a matrix are generally described. In some embodiments, an electric field may be used to alter the position of the molecule with respect to the matrix. The electric field may be used to move the molecule to a new location within the matrix, remove the molecule from the matrix, or infuse the molecule into the matrix. For instance, the electric field may be used to move a molecule having a binding partner within the matrix into or away from the vicinity of the binding partner. In some embodiments, the position of the molecule may be altered by exposing the molecule to an electrodynamic field. In some such embodiments, the molecule exposed to the dynamic electric field may have enhanced mobility and minimal adverse matrix interactions relative to conventional molecular transport methods, and in some cases, a molecule exposed to an electrostatic field. The active transport methods and articles, described herein, may be particularly well-suited for a variety of applications including histological, biological, and pharmaceutical applications.