Jeffery W. Kelly - La Jolla CA, US Evan T. Powers - La Jolla CA, US Hossein Razavi - Danbury CT, US
Assignee:
The Scripps Research Institute - La Jolla CA
International Classification:
A61K 31/423
US Classification:
514375, 548224, 548236
Abstract:
Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin amyloid diseases, inhibiting such misfolding can be used as an effective treatment or prophylaxis for such diseases. Treatment methods are disclosed.
Methods For Treating Transthyretin Amyloid Diseases
Jeffery W. KELLY - La Jolla CA, US Evan T. POWERS - La Jolla CA, US Hossein RAZAVI - Danbury CT, US
Assignee:
THE SCRIPPS RESEARCH INSTITUTE - La Jolla CA
International Classification:
A61K 31/423 A61P 9/00 A61P 25/00
US Classification:
514375
Abstract:
Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin amyloid diseases, inhibiting such misfolding can be used as an effective treatment or prophylaxis for such diseases. Treatment methods are disclosed.
Compositions And Methods For Stabilizing Transthyretin And Inhibiting Transthyretin Misfolding
Jeffery W. Kelly - La Jolla CA, US Evan T. Powers - La Jolla CA, US Hossein Razavi - Danbury CT, US
Assignee:
The Scripps Research Institute - La Jolla CA
International Classification:
C07D 263/57 A61K 31/4245
US Classification:
514375, 548224
Abstract:
Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin amyloid diseases, inhibiting such misfolding can be used as an effective treatment or prophylaxis for such diseases. Treatment methods, screening methods, as well as specific transthyretin stabilizing compounds are disclosed.
Methods For Treating Transthyretin Amyloid Diseases
- La Jolla CA, US Evan T. POWERS - La Jolla CA, US Hossein RAZAVI - Danbury CT, US
Assignee:
The Scripps Research Institute - La Jolla CA
International Classification:
G01N 33/566
US Classification:
436501
Abstract:
Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin amyloid diseases, inhibiting such misfolding can be used as an effective treatment or prophylaxis for such diseases. Treatment methods are disclosed.
Resumes
Associate Professor At The Scripps Research Institute
Ziegler will face GOP state and county leaders on Jan. 8 in Tallahassee, where members are expected to oust him from his post. Evan Powers, the current vice chair who is leading the group, will also run to replace him that same day.