Fan Chen

US Patent:

7892795, Feb 22, 2011

Filed:

Oct 6, 2005

Appl. No.:

11/246904

Inventors:

Fan Chen - Fullerton CA, US
Lilly I. Kong - Covina CA, US
Jules Chen - Walnut CA, US
Mehrdad Jannatipour - Oceanside CA, US

Assignee:

Focus Diagnostics, Inc. - Herndon VA

International Classification:

C12P 19/34
C12Q 1/68
C07H 21/02
C07H 21/04

US Classification:

435 912, 435 6, 536 2433, 536 231

Abstract:

The invention provides methods and compositions for rapid, sensitive, and highly specific nucleic acid-based (e. g. , DNA based) detection of a BK virus in a sample. In general, the methods involve detecting a target nucleic acid having a target sequence of a conserved region of BK viral genomes. The invention also features compositions, including primers, probes, and kits, for use in the methods of the invention.

US Patent:

8196218, Jun 5, 2012

Filed:

Mar 30, 2009

Appl. No.:

12/414069

Inventors:

Bingqian Xu - Athens GA, US
Fan Chen - Seattle WA, US

Assignee:

University of Georgia Research Foundation, Inc. - Athens GA

International Classification:

G01Q 60/40

US Classification:

850 41, 850 10, 850 52, 324693, 324661, 324664, 324425, 204556, 204547

Abstract:

An exemplary, highly integrated, SPM-based system for measuring the conductivity and/or force of substance under programmable engaging/stretching processes is described. A sample bias is applied across two electrodes. A substance to be measured is sandwiched between them. A first electrode is first brought relative to a second electrode (engaging) in programmable pathways that can be described as stretching distance versus time curves. The process of engaging the electrodes continues until a certain current reached, a certain force reached and whichever case happens first. The electrodes are then separated (stretching) in programmable pathways that can be described as stretching distance versus time curves. A periodic modulation can be applied to the engaging/stretching process to realize different stretch pathways. The sample bias across the electrodes is kept constant or swept in a programmable shape over time, described as a voltage-versus time curve.

US Patent:

8354230, Jan 15, 2013

Filed:

Dec 21, 2007

Appl. No.:

11/963699

Inventors:

Jules Chen - Walnut CA, US
Lilly I. Kong - Covina CA, US
Fan Chen - Fullerton CA, US
Michelle M. Tabb - Santa Ana CA, US
Michael Aye - Fountain Valley CA, US

Assignee:

Quest Diagnostics Investments Inc. - Wilmington DE

International Classification:

C12Q 1/68
C12P 19/34
C07H 21/04

US Classification:

435 612, 435 912, 536 243

Abstract:

The present invention generally relates to a molecular test of Influenza A, Influenza B, Respiratory Syncytial Virus A, and Respiratory Syncytial Virus B in order to identify patients with a viral infection. Accordingly methods and compositions are disclosed to determine the presence or absence of a viral pathogen in a sample containing one or more target nucleic acids from the M gene of Influenza A, Influenza B, Respiratory Syncytial Virus A, and/or Respiratory Syncytial Virus B.

US Patent:

20090092969, Apr 9, 2009

Filed:

Oct 9, 2007

Appl. No.:

11/869650

Inventors:

Michael Aye - Fountain Valley CA, US
Lilly I. Kong - Covina CA, US
Michelle M. Tabb - Santa Ana CA, US
Fan Chen - Fullerton CA, US
Jules Chen - Walnut CA, US

International Classification:

C12Q 1/68
C07H 21/00

US Classification:

435 6, 536 231

Abstract:

Disclosed herein are methods and compositions for detecting one or more pathogens that cause atypical pneumonia. Detectable pathogens include , and

US Patent:

20090197262, Aug 6, 2009

Filed:

May 7, 2008

Appl. No.:

12/116364

Inventors:

Michelle M. Tabb - Santa Ana CA, US
Lilly I. Kong - Covina CA, US
Ning Lu - Pleasanton CA, US
Michael Aye - Fountain Valley CA, US
Fan Chen - Fullerton CA, US
Jules Chen - Walnut CA, US

International Classification:

C12Q 1/68
C07H 21/04

US Classification:

435 6, 536 237

Abstract:

Disclosed herein are methods and compositions for detecting and by detecting the presence of the IS481 and IS1001 genomic insertion sequences, respectively.

US Patent:

20090226889, Sep 10, 2009

Filed:

Jan 14, 2008

Appl. No.:

12/014063

Inventors:

Fan Chen - Fullerton CA, US
Lilly I. Kong - Covina CA, US
Jules Chen - Walnut CA, US
Michelle M. Tabb - Santa Ana CA, US
Michael Aye - Fountain Valley CA, US

International Classification:

C12Q 1/70

US Classification:

435 5

Abstract:

The present invention generally relates to a molecular test of enterovirus, herpes simplex virus-1 and -2, and/or Varicella-Zoster virus, in order to identify patients with a viral infection, in particular a viral infection of the central nervous system. Accordingly methods and compositions are disclosed to determine the presence or absence of a viral pathogen in a biological sample comprising, wherein the target nucleic acids comprise the 5′ UTR of the enterovirus genome, UL29 of herpes simplex virus and gene 36 of Varicella-Zoster virus.

US Patent:

20110143349, Jun 16, 2011

Filed:

Jan 12, 2011

Appl. No.:

13/005490

Inventors:

Fan Chen - Fullerton CA, US
Lilly I. Kong - Covina CA, US
Jules Chen - Walnut CA, US
Mehrdad Jannatipour - Oceanside CA, US

International Classification:

C12Q 1/68

US Classification:

435 611

Abstract:

The invention provides methods and compositions for rapid, sensitive, and highly specific nucleic acid-based (e.g., DNA based) detection of a BK virus in a sample. In general, the methods involve detecting a target nucleic acid having a target sequence of a conserved region of BK viral genomes. The invention also features compositions, including primers, probes, and kits, for use in the methods of the invention.

US Patent:

20200123596, Apr 23, 2020

Filed:

Oct 29, 2019

Appl. No.:

16/667092

Inventors:

- Secaucus NJ, US
Ming-Chou Lee - Mission Vlejo CA, US
Lilly I. Kong - Covina CA, US
Ning Lu - Pleasonton CA, US
Michael Aye - Fountain Valley CA, US
Fan Chen - Fullerton CA, US
Jules Chen - , US

Assignee:

Quest Diagnostics Investments LLC - Secaucus NJ

International Classification:

C12Q 1/689

Abstract:

Disclosed herein are methods and compositions for detecting and by detecting the presence of the IS481 and IS1001 genomic insertion sequences, respectively.