Fan Tracy D Chen

US Patent:

7892795, Feb 22, 2011

Filed:

Oct 6, 2005

Appl. No.:

11/246904

Inventors:

Fan Chen - Fullerton CA, US
Lilly I. Kong - Covina CA, US
Jules Chen - Walnut CA, US
Mehrdad Jannatipour - Oceanside CA, US

Assignee:

Focus Diagnostics, Inc. - Herndon VA

International Classification:

C12P 19/34
C12Q 1/68
C07H 21/02
C07H 21/04

US Classification:

435 912, 435 6, 536 2433, 536 231

Abstract:

The invention provides methods and compositions for rapid, sensitive, and highly specific nucleic acid-based (e. g. , DNA based) detection of a BK virus in a sample. In general, the methods involve detecting a target nucleic acid having a target sequence of a conserved region of BK viral genomes. The invention also features compositions, including primers, probes, and kits, for use in the methods of the invention.

US Patent:

8354230, Jan 15, 2013

Filed:

Dec 21, 2007

Appl. No.:

11/963699

Inventors:

Jules Chen - Walnut CA, US
Lilly I. Kong - Covina CA, US
Fan Chen - Fullerton CA, US
Michelle M. Tabb - Santa Ana CA, US
Michael Aye - Fountain Valley CA, US

Assignee:

Quest Diagnostics Investments Inc. - Wilmington DE

International Classification:

C12Q 1/68
C12P 19/34
C07H 21/04

US Classification:

435 612, 435 912, 536 243

Abstract:

The present invention generally relates to a molecular test of Influenza A, Influenza B, Respiratory Syncytial Virus A, and Respiratory Syncytial Virus B in order to identify patients with a viral infection. Accordingly methods and compositions are disclosed to determine the presence or absence of a viral pathogen in a sample containing one or more target nucleic acids from the M gene of Influenza A, Influenza B, Respiratory Syncytial Virus A, and/or Respiratory Syncytial Virus B.

US Patent:

20030138830, Jul 24, 2003

Filed:

Nov 27, 2002

Appl. No.:

10/306828

Inventors:

Yan Wang - San Francisco CA, US
Michael Finney - San Francisco CA, US
Fan Chen - Alameda CA, US

Assignee:

MJ Bioworks Incorporated - South San Francisco CA

International Classification:

C12Q001/68
C12P019/34
C12N009/22

US Classification:

435/006000, 435/091200, 435/199000

Abstract:

This invention provides a method of detecting polymorphisms, e.g., single nucleotide polymorphisms (SNPs), by amplification and error correction. The invention encompasses methods of performing amplification and error correction using an improved generation of nucleic acid polymerases, and methods of multiplexing the assay. The improvement to the polymerases is the joining of a sequence-non-specific nucleic-acid-binding domain to the enzyme in a manner that enhances the ability of the enzyme to bind and catalytically modify the nucleic acid.

US Patent:

20060051749, Mar 9, 2006

Filed:

Nov 27, 2002

Appl. No.:

10/496702

Inventors:

Yan Wang - San Francisco CA, US
Lei Xi - Foster City CA, US
Michael Finney - San Francisco CA, US
Fan Chen - Fullerton CA, US

Assignee:

MJ BIOWORKS INCORPORATED - South San Francisco

International Classification:

C12Q 1/68
C12P 19/34

US Classification:

435006000, 435091200

Abstract:

The current invention provides a method of performing DNA polymorphism assays. The assay combines allele-specific PCR with technology used for quantitative PCR. The method can be used to score the presence of absence of particular polymorphisms in a DNA sample. In a further aspect of the invention, the method is used to score the presence or absence of particular haplotypes in a DNA sample.

US Patent:

20070009954, Jan 11, 2007

Filed:

Sep 15, 2006

Appl. No.:

11/521754

Inventors:

Yan Wang - San Francisco CA, US
Michael Finney - San Francisco CA, US
Fan Chen - Alameda CA, US

Assignee:

Bio-Rad Laboratories, Inc. - Hercules CA

International Classification:

C12Q 1/68
C12P 19/34
C07H 21/04

US Classification:

435006000, 435091200, 536025320

Abstract:

This invention provides a method of detecting polymorphisms, e.g., single nucleotide polymorphisms (SNPs), by amplification and error correction. The invention encompasses methods of performing amplification and error correction using an improved generation of nucleic acid polymerases, and methods of multiplexing the assay. The improvement to the polymerases is the joining of a sequence-non-specific nucleic-acid-binding domain to the enzyme in a manner that enhances the ability of the enzyme to bind and catalytically modify the nucleic acid.

US Patent:

20090092969, Apr 9, 2009

Filed:

Oct 9, 2007

Appl. No.:

11/869650

Inventors:

Michael Aye - Fountain Valley CA, US
Lilly I. Kong - Covina CA, US
Michelle M. Tabb - Santa Ana CA, US
Fan Chen - Fullerton CA, US
Jules Chen - Walnut CA, US

International Classification:

C12Q 1/68
C07H 21/00

US Classification:

435 6, 536 231

Abstract:

Disclosed herein are methods and compositions for detecting one or more pathogens that cause atypical pneumonia. Detectable pathogens include , and

US Patent:

20090197262, Aug 6, 2009

Filed:

May 7, 2008

Appl. No.:

12/116364

Inventors:

Michelle M. Tabb - Santa Ana CA, US
Lilly I. Kong - Covina CA, US
Ning Lu - Pleasanton CA, US
Michael Aye - Fountain Valley CA, US
Fan Chen - Fullerton CA, US
Jules Chen - Walnut CA, US

International Classification:

C12Q 1/68
C07H 21/04

US Classification:

435 6, 536 237

Abstract:

Disclosed herein are methods and compositions for detecting and by detecting the presence of the IS481 and IS1001 genomic insertion sequences, respectively.

US Patent:

20090226889, Sep 10, 2009

Filed:

Jan 14, 2008

Appl. No.:

12/014063

Inventors:

Fan Chen - Fullerton CA, US
Lilly I. Kong - Covina CA, US
Jules Chen - Walnut CA, US
Michelle M. Tabb - Santa Ana CA, US
Michael Aye - Fountain Valley CA, US

International Classification:

C12Q 1/70

US Classification:

435 5

Abstract:

The present invention generally relates to a molecular test of enterovirus, herpes simplex virus-1 and -2, and/or Varicella-Zoster virus, in order to identify patients with a viral infection, in particular a viral infection of the central nervous system. Accordingly methods and compositions are disclosed to determine the presence or absence of a viral pathogen in a biological sample comprising, wherein the target nucleic acids comprise the 5′ UTR of the enterovirus genome, UL29 of herpes simplex virus and gene 36 of Varicella-Zoster virus.