Zhiguo J. Song - Edison NJ, US Fei Zhang - Edison NJ, US Rebecca Leigh Shultz - Maplewood NJ, US
International Classification:
A61K 31/551 C07D 223/10
US Classification:
514218, 540529
Abstract:
Tartaric acid salts of (3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl) butanoyl]hexahydro-3-(2,2,2-trifluoroethyl)-2H-1,4-diazepin-2-one are potent inhibitors of dipeptidyl peptidase-IV and are useful for the prevention and/or treatment of non-insulin dependent diabetes mellitus, also referred to as Type 2 diabetes. The invention also relates to crystalline anhydrate forms of the tartaric acid salts as well as a process for their preparation, pharmaceutical compositions containing these novel forms and methods of use for the treatment of Type 2 diabetes.
Name / Title
Company / Classification
Phones & Addresses
Fei Zhang
American Hawks LLC Whol Sporting/Recreational Goods
150 Maple Ave, South Plainfield, NJ 07080 58 Prestwick Way, Edison, NJ 08820
These two methods are not very scalable in terms of synthesis, said Fei Zhang, a senior co-author on the paper and Biodesign assistant research professor. When you have so many short pieces of DNA, you cant replicate it using biological systems."