Zhiguo J. Song - Edison NJ, US Fei Zhang - Edison NJ, US Rebecca Leigh Shultz - Maplewood NJ, US
International Classification:
A61K 31/551 C07D 223/10
US Classification:
514218, 540529
Abstract:
Tartaric acid salts of (3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl) butanoyl]hexahydro-3-(2,2,2-trifluoroethyl)-2H-1,4-diazepin-2-one are potent inhibitors of dipeptidyl peptidase-IV and are useful for the prevention and/or treatment of non-insulin dependent diabetes mellitus, also referred to as Type 2 diabetes. The invention also relates to crystalline anhydrate forms of the tartaric acid salts as well as a process for their preparation, pharmaceutical compositions containing these novel forms and methods of use for the treatment of Type 2 diabetes.
Rna-Nanostructured Double Robots And Methods Of Use Thereof
- Scottsdale AZ, US Hao YAN - Chandler AZ, US Xiaodong QI - Tempe AZ, US Fei ZHANG - Chandler AZ, US
International Classification:
C12N 15/117 A61K 39/00
Abstract:
Described herein are immuno-stimulatory RNA nanostructures (which comprises a single-stranded RNA (ssRNA) molecule, wherein the ssRNA molecule forms at least one paranemic cohesion crossover), as well as compositions and methods of use thereof.
Rna Nanostructures And Methods Of Making And Using Rna Nanostructures
- Scottsdale AZ, US Yung CHANG - Tempe AZ, US Xiaowei LIU - Tempe AZ, US Fei ZHANG - Chandler AZ, US Xiaodong QI - Tempe AZ, US
International Classification:
C12N 15/117
Abstract:
Certain embodiments provide RNA nanostructure (e.g., comprising one single-stranded RNA (ssRNA) molecule, wherein the RNA nanostructure comprises at least one paranemic cohesion crossover), as well as compositions and methods of use thereof. In certain embodiments, such RNA nanostructures are immuno-modulatory (e.g., immuno-stimulatory).
Rna-Nanostructured Double Robots And Methods Of Use Thereof
- Skysong - Suite 200 AZ, US Hao YAN - Chandler AZ, US Xiaodong QI - Tempe AZ, US Fei ZHANG - Chandler AZ, US
International Classification:
C12N 15/117 A61K 39/00
Abstract:
Described herein are immuno-stimulatory RNA nanostructures (which comprises a single-stranded RNA (ssRNA) molecule, wherein the ssRNA molecule forms at least one paranemic cohesion crossover), as well as compositions and methods of use thereof.
Name / Title
Company / Classification
Phones & Addresses
Fei Zhang
American Hawks LLC Whol Sporting/Recreational Goods
150 Maple Ave, South Plainfield, NJ 07080 58 Prestwick Way, Edison, NJ 08820
These two methods are not very scalable in terms of synthesis, said Fei Zhang, a senior co-author on the paper and Biodesign assistant research professor. When you have so many short pieces of DNA, you cant replicate it using biological systems."