Method For Efficiently Simulating The Information Processing In Cells And Tissues Of The Nervous System With A Temporal Series Compressed Encoding Neural Network
A neural network simulation represents components of neurons by finite state machines, called sectors, implemented using look-up tables. Each sector has an internal state represented by a compressed history of data input to the sector and is factorized into distinct historical time intervals of the data input. The compressed history of data input to the sector may be computed by compressing the data input to the sector during a time interval, storing the compressed history of data input to the sector in memory, and computing from the stored compressed history of data input to the sector the data output from the sector.
Calculating Confidence Levels For Peptide And Protein Identification
Computer programs and methods for defining a misidentification probability for an experimental protein divisible into experimental peptides. The invention receives data representing a set of matches of experimental peptides to reference peptides that can be derived from a protein in a database of proteins; calculates a probability of observing by chance, in a search of the database of proteins, a set of matches equivalent to or better than the represented set of matches; and defines the misidentification probability using the probability of observing by chance a set of matches equivalent to or better than the represented set of matches.
Methods, systems and apparatus implement techniques for identifying modifications in polypeptides. A set of candidate sequences is identified that includes sequence information potentially corresponding to an unmodified variant of the polypeptide. Peptides derived from the polypeptide are sequenced to identify sequence tags. The sequence tags are compared with sequence information for the set of candidate sequences to identify a candidate sequence containing the sequence tags. For each such sequence tag, the difference between at least one subsequence mass of the corresponding peptide and at least one subsequence mass of the identified candidate sequence is calculated. The candidate sequences containing the sequence tags can be identified by searching a reduced database constructed based on the identified set of candidate sequences.