Frances M Hocutt

US Patent:

20110046132, Feb 24, 2011

Filed:

Apr 28, 2009

Appl. No.:

12/990104

Inventors:

Frances Meredith Hocutt - San Diego CA, US
Hillary M. Peltier - San Diego CA, US
Victor K. Phuong - San Diego CA, US
Michael H. Rabinowitz - San Diego CA, US
Mark D. Rosen - San Diego CA, US
Kyle T. Tarantino - San Diego CA, US
Hariharan Venkatesan - San Diego CA, US
Lucy Xiumin Zhao - San Diego CA, US

International Classification:

A61K 31/5377
C07D 403/04
C07D 403/14
C07D 401/14
C07D 413/14
C07D 471/04
C07D 513/04
C07D 487/14
C07D 487/04
C07D 473/40
A61K 31/4184
A61K 31/454
A61K 31/437
A61K 31/429
A61K 31/496
A61K 31/4985
A61K 31/52
A61P 7/06
A61P 9/10
A61P 9/00
A61P 3/10
A61P 3/04
A61P 29/00
A61P 17/02
A61P 19/08

US Classification:

5142345, 5483061, 546199, 544139, 546 82, 5483021, 548151, 544370, 544345, 544350, 544277, 514395, 514322, 514293, 514366, 51425406, 514250, 5142632

Abstract:

The present invention is directed to benzoimidazole compounds of the formula (1) and enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts thereof. Compounds of the present invention are useful in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions modulated by prolyl hydroxylase activity.

US Patent:

20100204226, Aug 12, 2010

Filed:

Feb 10, 2010

Appl. No.:

12/703705

Inventors:

Scott D. Bembenek - San Diego CA, US
Frances M. Hocutt - San Diego CA, US
Michael H. Rabinowitz - San Diego CA, US
Mark D. Rosen - San Diego CA, US
Kyle T. Tarantino - San Diego CA, US
Hariharan Venkatesan - San Diego CA, US

International Classification:

A61K 31/517
C07D 403/04
C07D 487/04
A61K 31/519
C07D 413/14
A61K 31/5377
A61P 7/06
A61P 9/10
A61P 3/10
A61P 3/04
A61P 1/00
A61P 1/04
A61P 31/00
A61P 17/02
C07D 401/14

US Classification:

5142345, 544284, 51426623, 544250, 514267, 51426621, 51426622, 51425217, 544116, 544249

Abstract:

Quinazolinone compounds of formula (I) are described,which are useful as prolyl hydroxylase inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by prolyl hydroxylase activity. Thus, the compounds may be administered to treat, e.g., anemia, vascular disorders, metabolic disorders, and wound healing.

US Patent:

20190144916, May 16, 2019

Filed:

Dec 18, 2018

Appl. No.:

16/224001

Inventors:

- Seattle WA, US
Arun Babu Kumar - Seattle WA, US
Frances Hocutt - Seattle WA, US
Zdenek Spacil - Seattle WA, US
Mariana Natali Barcenas Rodriguez - Seattle WA, US
Frantisek Turecek - Seattle WA, US
C. Ronald Scott - Seattle WA, US

Assignee:

University of Washington through its Center for Commercialization - Seattle WA

International Classification:

C12Q 1/34
C07H 15/203

Abstract:

Reagents, methods, and kits for assaying enzymes associated with lysosomal storage diseases MPS-I, MPS-II, MPS-IIIA, MPS-IIIB, MPS-IVA, MPS-VI, and MPS VII.

US Patent:

20160298166, Oct 13, 2016

Filed:

Sep 5, 2014

Appl. No.:

14/916526

Inventors:

- Seattle WA, US
Arun Babu Kumar - Seattle WA, US
Frances Hocutt - Seattle WA, US
Zdenek Spacil - Seattle WA, US
Mariana Natali Barcenas Rodriguez - Seattle WA, US
Frantisek Turecek - Seattle WA, US
C. Ronald Scott - Seattle WA, US

Assignee:

University of Washington through its Center for Commercialization - Seattle WA

International Classification:

C12Q 1/34
C07H 15/203

Abstract:

Reagents, methods, and kits for assaying enzymes associated with lysosomal storage diseases MPS-I, MPS-II, MPS-IIIA, MPS-IIIB, MPS-IV A, MPS-VI, and MPS VII. In one aspect, the invention provides methods for assaying one or more enzymes associated with a lysosomal storage disease. In a first embodiment, the method includes: (a) contacting a sample with a first solution to provide a solution comprising one or more lysosomal enzymes; (b) contacting the one or more lysosomal enzymes in solution with an enzyme substrate for each lysosomal enzyme to be analyzed and incubating the substrates with the enzymes for a time sufficient to provide a solution comprising an enzyme product for each lysosomal enzyme present in the sample.