Romulus Brazzell - Alpharetta GA, US Peter Campochiaro - Baltimore MD, US Kenneth Green - Alpharetta GA, US Frances Kane - Cumming GA, US
International Classification:
A61K031/553
US Classification:
514/211080
Abstract:
The invention provides methods for decreasing or attenuating an increase in capillary permeability in a subject in need of treatment by administering a composition comprising an amount of a staurosporine derivative or salt thereof to a subject suffering from excessive or pathological capillary permeability in the retina effective to decrease the permeability of the retinal capillaries of the subject.
Method For Decreasing Capillary Permeability In The Retina
Romulus Brazzell - Alpharetta GA, US Kenneth Green - Alpharetta GA, US Frances Kane - Cumming GA, US Peter Campochiaro - Baltimore MD, US
International Classification:
A61K031/553
US Classification:
514/211080
Abstract:
Disclosed are methods for decreasing or attenuating an increase in capillary permeability in the retina in a subject in need of such treatment, comprising administering a composition comprising an amount of a staurosporine derivative or a salt thereof to a subject suffering from excessive or pathological capillary permeability in the retina, the amount of staurosporine derivative or salt thereof being effective to decrease the permeability of capillaries in the retina of the subject.
Method For Decreasing Capillary Permeability In The Retina
Romulus Brazzell - Alpharetta GA, US Kenneth Green - Alpharetta GA, US Frances Kane - Cumming GA, US Peter Campochiaro - Baltimore MD, US
International Classification:
A61K031/502
US Classification:
514248000
Abstract:
Disclosed herein are methods for decreasing or attenuating an increase in capillary permeability in the retina in a subject in need of such treatment, comprising administering a composition comprising an amount of a phthalazine derivative or a salt thereof to a subject suffering from excessive or pathological capillary permeability in the retina, the amount of phthalazine derivative or salt thereof being effective to decrease the permeability of capillaries in the retina of the subject, in particular where the subject is suffering from macular edema.
Method For Decreasing Capillary Permeability In The Retina
Romulus Kimbro Brazzell - Alpharetta GA, US Kenneth E. Green - Alpharetta GA, US Frances Elizabeth Kane - Cumming GA, US Peter Anthony Campochiaro - Baltimore MD, US
International Classification:
A61K 31/502 A61P 27/02
US Classification:
514248
Abstract:
Disclosed herein are methods for decreasing or attenuating an increase in capillary permeability in the retina in a subject in need of such treatment, comprising administering a composition comprising an amount of a phthalazine derivative or a salt thereof to a subject suffering from excessive or pathological capillary permeability in the retina, the amount of phthalazine derivative or salt thereof being effective to decrease the permeability of capillaries in the retina of the subject.
Romulus Kimbro Brazzell - Alpharetta GA Jeanette Marjorie Wood - Biel Benken, CH Peter Anthony Campochiaro - Baltimore MD Frances Elizabeth Kane - Gainesville GA
Assignee:
Novartis AG - Basel
International Classification:
A61K 31395
US Classification:
51421108
Abstract:
The invention provides a method for treating or preventing ocular neovascularization. The method administers an effective amount of a staurosporine derivative to treat or prevent retinal or choroidal neovascularization. In each case, the effect on the pathologic blood vessels is dramatic and profound with complete or near-complete inhibition, but there is no identifiable toxic effect on mature retinal vessels.
Romulus Kimbro Brazzell - Alpharetta GA Jeanette Marjorie Wood - Biel Benken, CH Peter Anthony Campochiaro - Baltimore MD Frances Elizabeth Kane - Gainesville GA
Assignee:
CIBA Vision Corporation - Deluth GA
International Classification:
A01N 4358
US Classification:
514249
Abstract:
The invention relates to the use of certain phthalazines in the preparation of medicaments for the treatment of ocular neovascularization.
Frances Kane 1980 graduate of Arizona Western College in Yuma, AZ is on Memory Lane. Get caught up with Frances and other high school alumni from Arizona