Frances M Nelson

US Patent:

6465508, Oct 15, 2002

Filed:

Feb 23, 2001

Appl. No.:

09/792798

Inventors:

Frances Christy Nelson - Wyckoff NJ
Arie Zask - New York NY
James Ming Chen - San Ramon CA
Dominick Mobilio - Warren NJ
Ramaswamy Nilakantan - Closter NJ

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 3138

US Classification:

514443, 514469, 514470, 549 49, 549 51, 549 52, 549 53, 549 57, 549 58, 549466, 549467, 549468, 549470, 549471

Abstract:

Ortho-sulfonamido aryl hydroxamic acids are provided which are useful, inter alia, for the inhibition of matrix metalloproteinases and the treatment of conditions associated with overexpression of MMPs.

US Patent:

6825352, Nov 30, 2004

Filed:

Aug 30, 2002

Appl. No.:

10/231584

Inventors:

Frances Christy Nelson - Wyckoff NJ
Arie Zask - New York NY
James Ming Chen - San Ramon CA
Dominick Mobilio - Warren NJ
Ramaswamy Nilakantan - Closter NJ

Assignee:

Wyeth - Madison NJ

International Classification:

C07D21516

US Classification:

546153, 546155, 546156, 546157, 546159, 546162, 546167, 546168, 546170, 548483, 548484, 548486, 548492, 548494, 548503, 548509, 548511

Abstract:

Ortho-sulfonamido aryl hydroxamic acids are provided which are useful, inter alia, for the inhibition of matrix metalloproteinases and the treatment of conditions associated with overexpression of MMPs.

US Patent:

7470794, Dec 30, 2008

Filed:

Nov 4, 2004

Appl. No.:

10/980990

Inventors:

Frances Christy Nelson - Wyckoff NJ, US
Arie Zask - New York NY, US
James Ming Chen - San Ramon CA, US
Dominick Mobilio - Warren NJ, US
Ramaswamy Nilakantan - Closter NJ, US

Assignee:

Wyeth - Madison NJ

International Classification:

C07D 263/02

US Classification:

548215

Abstract:

Ortho-sulfonamido aryl hydroxamic acids are provided which are useful, inter alia, for the inhibition of matrix metalloproteinases and the treatment of conditions associated with overexpression of MMPs.

US Patent:

60573406, May 2, 2000

Filed:

Feb 3, 1999

Appl. No.:

9/243589

Inventors:

Michael G. Kelly - Plainsboro NJ
Lynne P. Greenblatt - Lambertville NJ
Frances C. Nelson - Wyckoff NJ

Assignee:

American Home Products Corporation - Madison NJ

International Classification:

A61K 31445
C07D40106
C07D41306

US Classification:

514326

Abstract:

This invention provides compounds of Formula 1 having the structure ##STR1## wherein: R. sub. 1 is hydrogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, benzyloxy, trifluoromethyl, chloro, bromo, or fluoro; a dashed line indicates an optional bond, X is NR. sub. 4, or no atom; R. sub. 2 is alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, cycloalkylalkyl wherein the cycloalkyl moiety is 3-8 carbon atoms and the alkyl moiety is 1-6 carbon atoms, aryl of 5-12 carbon atoms, or arylalkyl of 6-12 carbon atoms; R. sub. 3 is aryl of 5-12 carbon atoms, arylalkyl of 6-12 carbon atoms, or heteroaryl of 5-12 atoms; R. sub. 4 is hydrogen or alkyl of 1-6 carbon atoms; or a pharmaceutically acceptable salt thereof, which are useful in the treatment of psychosis (e. g. schizophrenia), anxiety, depression and related CNS disorders and other conditions such as the treatment of alcohol and drug withdrawal, sexual dysfunction and memory deficits associated with Alzheimer's disease and other dementias.