Francis Kalush

US Patent:

6818758, Nov 16, 2004

Filed:

Jan 24, 2001

Appl. No.:

09/768185

Inventors:

Francis Kalush - Rockville MD
Michael J Cassel - San Leandro CA
Stuart Soo-In Hwang - San Carlos CA
Emily S Winn-Deen - Potomac MD

Assignee:

Applera Corporation - Norwalk CT

International Classification:

C12Q 168

US Classification:

536 243, 435 912, 435 6, 536 235, 536 2431, 536 2532

Abstract:

The present invention is based on sequencing genomic DNA from human chromosome 6 and cDNAs to define the genomic structure of estrogen receptor beta genes and novel polymorphism in the estrogen receptor gene/protein. Such polymorphism can lead to a variety of disorders that are mediated/modulated by a variant estrogen receptor, such as a susceptibility to cancer, osteoporosis, cardiovascular disorder, etc. Based on this sequencing approach, the present invention provides genomic nucleotide sequences, cDNA sequences, amino acid sequences and sequence polymorphism in the ESR-beta genes, methods of detecting these sequences/polymorphism in a sample, methods of determining a risk of having or developing a disorder mediated by a variant estrogen receptor and methods of screening for compounds used to treat disorders mediated by a variant estrogen receptor.

US Patent:

6825336, Nov 30, 2004

Filed:

Sep 10, 2001

Appl. No.:

09/949001

Inventors:

J. Craig Venter - Rockville MD
Jinghui N. Zhang - Rockville MD
Xiangjun Liu - Olney MD
William Rowe - Rockville MD
Anibal Cravchik - Gaithersburg MD
Francis Kalush - Rockville MD
Ashwinikumar Naik - Gaithersburg MD
Gangadharan Subramanian - Columbia MD
Trevor Woodage - Washington DC

Assignee:

Applera Corporation - Norwalk CT

International Classification:

C07H 2104

US Classification:

536 2431, 536 233, 536 2433, 536 231

Abstract:

The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to osteoporosis. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant osteoporosis associated protein. The present invention provides reagents used for detecting and expressing the variant nucleic acid/protein sequence as well as methods of identifying and using these variants.

US Patent:

6900016, May 31, 2005

Filed:

Sep 10, 2001

Appl. No.:

09/949002

Inventors:

J. Craig Venter - Rockville MD, US
Jinghui N. Zhang - Rockville MD, US
Xiangjun Liu - Olney MD, US
William Rowe - Rockville MD, US
Anibal Cravchik - Gaithersburg MD, US
Francis Kalush - Rockville MD, US
Ashwinikumar Naik - Gaithersburg MD, US
Gangadharan Subramanian - Columbia MD, US
Trevor Woodage - Washington DC, US

Assignee:

Applera Corporation - Norwalk CT

International Classification:

C12Q001/68
C12P019/34
C07K013/00
C07H021/04

US Classification:

435 6, 435 912, 4353201, 530350, 536 234

Abstract:

The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to inflammatory and autoimmune disorders. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant inflammatory and autoimmune disorders associated protein. The present invention provides reagents used for detecting and expressing the variant nucleic acid/protein sequence as well as methods of identifying and using these variants.

US Patent:

20020123095, Sep 5, 2002

Filed:

Aug 21, 2001

Appl. No.:

09/933267

Inventors:

Francis Kalush - Rockville MD, US
Michael Cassel - San Leandro CA, US
Stuart Hwang - San Carlos CA, US
Emily Winn-Deen - Potomac MD, US

Assignee:

PE CORPORATION (NY) - Norwalk CT

International Classification:

C07K014/705
C07H021/04
C07K016/28
C12P021/02
C12N005/06

US Classification:

435/069100, 435/325000, 435/320100, 530/350000, 536/023500, 530/388220

Abstract:

The present invention is based on sequencing genomic DNA from human chromosome 6 and cDNAs to define the genomic structure of estrogen receptor alpha genes and novel polymorphism/haplotypes in the estrogen receptor gene/protein. Such polymorphism/haplotypes can lead to a variety of disorders that are mediated/modulated by a variant estrogen receptor, such as a susceptibility to cancer, osteoporosis, cardiovascular disorder, etc. Based on this sequencing approach, the present invention provides genomic nucleotide sequences, cDNA sequences, amino acid sequences and sequence polymorphism/haplotypes in the ESR-alpha genes, methods of detecting these sequences/polymorphism/haplotypes in a sample, methods of determining a risk of having or developing a disorder mediated by a variant estrogen receptor and methods of screening for compounds used to treat disorders mediated by a variant estrogen receptor.

US Patent:

20050147987, Jul 7, 2005

Filed:

Jul 19, 2004

Appl. No.:

10/893315

Inventors:

J. Venter - Rockville MD, US
Jinghui Zhang - Rockville MD, US
Xiangjun Liu - Olney MD, US
William Rowe - Rockville MD, US
Anibal Cravchik - Gaithersburg MD, US
Francis Kalush - Rockville MD, US
Ashwinikumar Naik - Gaithersburg MD, US
Gangadharan Subramanian - Columbia MD, US
Trevor Woodage - Washington DC, US

Assignee:

APPLERA CORPORATION (NY) - Norwalk CT

International Classification:

C12Q001/68
C07H021/04

US Classification:

435006000, 536024300

Abstract:

The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to type II diabetes and obesity. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant type II diabetes and obesity associated protein. The present invention provides reagents used for detecting and expressing the variant nucleic acid/protein sequence as well as methods of identifying and using these variants.

US Patent:

20070037162, Feb 15, 2007

Filed:

Jul 19, 2004

Appl. No.:

10/893319

Inventors:

J. Venter - Rockville MD, US
Jinghui Zhang - Rockville MD, US
Xiangjun Liu - Olney MD, US
William Rowe - Rockville MD, US
Anibal Cravchik - Gaithersburg MD, US
Francis Kalush - Rockville MD, US
Ashwinikumar Naik - Gaithersburg MD, US
Gangadharan Subramanian - Columbia MD, US
Trevor Woodage - Washington DC, US

Assignee:

APPLERA CORPORATION - Norwalk CT

International Classification:

C12Q 1/68
C07H 21/04

US Classification:

435006000, 536024300

Abstract:

The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to osteoporosis. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant osteoporosis associated protein. The present invention provides reagents used for detecting and expressing the variant nucleic acid/protein sequence as well as methods of identifying and using these variants.

US Patent:

20070037165, Feb 15, 2007

Filed:

Sep 15, 2004

Appl. No.:

10/940774

Inventors:

J. Venter - Rockville MD, US
Jinghui Zhang - Rockville MD, US
Xiangjun Liu - Olney MD, US
William Rowe - Rockville MD, US
Anibal Cravchik - Gaithersburg MD, US
Francis Kalush - Rockville MD, US
Ashwinikumar Naik - Gaithersburg MD, US
Gangadharan Subramanian - Columbia MD, US
Trevor Woodage - Washington DC, US

Assignee:

APPLERA CORPORATION - Norwalk CT

International Classification:

C12Q 1/68
C07H 21/04

US Classification:

435006000, 536024300

Abstract:

The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to human disease. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant human disease associated protein. The present invention provides reagents used for detecting and expressing the variant nucleic acid/protein sequence as well as methods of identifying and using these variants.

US Patent:

20070037168, Feb 15, 2007

Filed:

Jan 12, 2005

Appl. No.:

11/033545

Inventors:

J. Venter - Rockville MD, US
Jinghui Zhang - Rockville MD, US
Xiangjun Liu - Olney MD, US
William Rowe - Rockville MD, US
Anibal Cravchik - Gaithersburg MD, US
Francis Kalush - Rockville MD, US
Ashwinikumar Naik - Gaithersburg MD, US
Gangadharan Subramanian - Columbia MD, US
Trevor Woodage - Washington DC, US

Assignee:

APPLERA CORPORATION - Norwalk CT

International Classification:

C12Q 1/68
C07H 21/04

US Classification:

435006000, 536024300

Abstract:

The present invention is based on the discovery of novel polymorphisms (SNPs) in the genes known in the art to contribute to inflammatory and autoimmune disorders. Such polymorphisms can lead to a variety of disorders that are mediated/modulated by a variant inflammatory and autoimmune disorders associated protein. The present invention provides reagents used for detecting and expressing the variant nucleic acid/protein sequence as well as methods of identifying and using these variants.