Francis L Martin

US Patent:

6586002, Jul 1, 2003

Filed:

Jun 8, 2001

Appl. No.:

09/877978

Inventors:

Samuel Zalipsky - Redwood City CA
Martin C. Woodle - Menlo Park CA
Francis J. Martin - San Francisco CA
Yechezkel Barenholz - Jerusalem, IL
Herve Bercovier - Jerusalem, IL

Assignee:

Alza Corporation - Mountain View CA

International Classification:

A61K 9127

US Classification:

424450, 424812, 424 852, 424 854, 424 858, 530319, 5303911, 530350, 530324, 530325, 530326, 530327, 530328, 530329, 530330, 530331

Abstract:

A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the bloodstream. The effector molecules are attached to the distal ends of the polymer chains. In one embodiment, the effector is polymyxin B, for treatment of septic shock.

US Patent:

7150882, Dec 19, 2006

Filed:

Apr 26, 2004

Appl. No.:

10/832636

Inventors:

Samuel Zalipsky - Redwood City CA, US
Martin C. Woodle - Menlo Park CA, US
Francis J. Martin - San Francisco CA, US
Yechezkel Barenholz - Jerusalem, IL
Herve Bercovier - Jerusalem, IL

Assignee:

Alza Corporation - Mountain View CA

International Classification:

A61K 9/127

US Classification:

424450, 424 858, 424 852, 424 854, 424812, 5303911, 530350

Abstract:

A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the bloodstream. The effector molecules are attached to the distal ends of the polymer chains. In one embodiment, the effector is polymyxin B, for treatment of septic shock.

US Patent:

7160554, Jan 9, 2007

Filed:

May 14, 2003

Appl. No.:

10/438502

Inventors:

Samuel Zalipsky - Redwood City CA, US
Martin C. Woodle - Menlo Park CA, US
Francis J. Martin - San Francisco CA, US
Yechezkel Barenholz - Jerusalem, IL
Herve Bercovier - Jerusalem, IL

Assignee:

ALZA Corporation - Mountain View CA

International Classification:

A61K 9/127

US Classification:

424450, 424 858, 424 852, 424 854, 424812, 5303911, 530350, 530331, 530330, 530329, 530328, 530327, 530326, 530325, 530324

Abstract:

A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the bloodstream. The effector molecules are attached to the distal ends of the polymer chains. In one embodiment, the effector is polymyxin B, for treatment of septic shock.

US Patent:

7438910, Oct 21, 2008

Filed:

Sep 5, 2003

Appl. No.:

10/656769

Inventors:

Brian Varnum - Santa Monica CA, US
Chris Vezina - Newbury Park CA, US
Alison Witte - Scotts Valley CA, US
Xueming Qian - Oak Park CA, US
Francis Hall Martin - Newbury Park CA, US
Haichun Huang - Fremont CA, US
Gary Elliott - Thousand Oaks CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA
Medarex, Inc. - Princeton NJ

International Classification:

A61K 39/395

US Classification:

4241441, 5303871, 5303882, 53038873

Abstract:

Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.

US Patent:

8121662, Feb 21, 2012

Filed:

Jul 5, 2007

Appl. No.:

11/773928

Inventors:

Francis Rajesh Martin - Santa Clara CA, US
Patrick Clement - Belmont, CH
Sameer Bidichandani - Los Gatos CA, US
Frederic Castella - Lausanne, CH

Assignee:

Marvell World Trade Ltd. - St. Michael

International Classification:

H04M 1/00

US Classification:

4555756, 4555501, 3794301

Abstract:

An apparatus and method for receiving wireless signals couples an antenna input of a receiver to a human body and receives a signal conducting from said body. Impedance matching circuitry lessens signal power loss at the antenna input. Parameters of the impedance matching circuitry can be adjusted based on a detected impedance, a detected signal strength, or the frequency of the signal.

US Patent:

8236559, Aug 7, 2012

Filed:

Sep 15, 2008

Appl. No.:

12/210313

Inventors:

Brian Varnum - Santa Monica CA, US
Chris Vezina - Newbury Park CA, US
Alison Witte - Scotts Valley CA, US
Xueming Qian - Oak Park CA, US
Francis Hall Martin - Newbury Park CA, US
Haichun Huang - Fremont CA, US
Gary Elliott - Thousand Oaks CA, US

Assignee:

Medarex, Inc. - Princeton NJ
Amgen Inc. - Thousand Oaks CA

International Classification:

C12N 5/16

US Classification:

435326, 536 2351

Abstract:

Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.

US Patent:

8518407, Aug 27, 2013

Filed:

Apr 18, 2012

Appl. No.:

13/450126

Inventors:

Brian Varnum - Santa Monica CA, US
Chris Vezina - Newbury Park CA, US
Alison Witte - Scotts Valley CA, US
Xueming Qian - Oak Park CA, US
Francis Hall Martin - Newbury Park CA, US
Haichun Huang - Fremont CA, US
Gary Elliott - Thousand Oaks CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA
Medarex, Inc. - Princeton NJ

International Classification:

A61K 39/395

US Classification:

4241441, 4241541

Abstract:

Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.

US Patent:

20030215490, Nov 20, 2003

Filed:

Apr 2, 2002

Appl. No.:

10/115566

Inventors:

Theresa Allen - Edmonton, CA
Paul Uster - Pleasanton CA, US
Francis Martin - San Francisco CA, US
Samuel Zalipsky - Redwood City CA, US

Assignee:

Sequus Pharmaceuticals, Inc.

International Classification:

A61K039/395
A61K009/127

US Classification:

424/450000, 424/143100, 424/141100

Abstract:

Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.