Francis E O'Donnell

US Patent:

20060019870, Jan 26, 2006

Filed:

Jan 28, 2005

Appl. No.:

11/047373

Inventors:

Francis O'Donnell - Town and Country MO, US
Raphael Mannino - Annandale NJ, US

International Classification:

A61K 38/17
A61K 31/685

US Classification:

514002000, 514078000

Abstract:

Disclosed herein are cochleates and cochleate compositions associated with an apoprotein component and/or a plasmid component that encodes an apoprotein. Also disclosed are methods of making and using the compositions of the invention, including methods of administration. Use of the invention provides safe, effective and efficient delivery of apoproteins and/or plasmids encoding the same in a variety of dosage forms.

US Patent:

20060029656, Feb 9, 2006

Filed:

Feb 3, 2005

Appl. No.:

11/051562

Inventors:

Francis O'Donnell - Town and Country MO, US
Raphael Mannino - Annandale NJ, US

Assignee:

BioDelivery Sciences International, Inc. - Newark NJ

International Classification:

A61K 38/46
A61K 38/47
A61K 9/127

US Classification:

424450000, 424094610, 424094600

Abstract:

Disclosed are cochleates and cochleate compositions that associated with an replacement enzyme component and/or a plasmid component that encodes a replacement enzyme. Also disclosed are methods of making and using the compositions of the invention, including methods of administration. Use of the invention provides safe, effective and efficient delivery of replacement enzymes and/or plasmids encoding the same in a variety of dosage forms.

US Patent:

20070123769, May 31, 2007

Filed:

Oct 4, 2006

Appl. No.:

11/542761

Inventors:

Terry Fuller - Jenkintown PA, US
Francis O'Donnell - Town and Country MO, US
Yongping Wang - Philadelphia PA, US

International Classification:

A61B 3/16
A61B 8/00

US Classification:

600405000, 600449000

Abstract:

An apparatus for determining intraocular pressure includes a transducer assembly containing an applanation tonometer for the determination of a cornea applanation pressure and an ultrasonic pachymeter to determine the thickness of the cornea at the site of applanation. The assembly has a tip end which includes an applanation surface and an ultrasonic coupler surface, and an end cap membrane holder is adapted to fit over the tip end of the transducer assembly and hold a thin film membrane stretched over the applanation and ultrasonic coupler surfaces. The transducer assembly also has a detector for detecting the presence or absence of the end cap membrane holder, the detector may generate a signal to disable movement of the transducer assembly if the end cap is not detected.

US Patent:

20080131420, Jun 5, 2008

Filed:

Jul 13, 2007

Appl. No.:

11/777890

Inventors:

Francis E. O'Donnell - Town and Country MO, US

Assignee:

Accentia, Inc. - Tampa FL

International Classification:

A61K 38/47
A61K 31/14
A61K 31/44
A61P 29/00
A61K 31/235

US Classification:

424 9462, 514643, 514277, 514543

Abstract:

Disclosed herein are methods for treating mucositis (e.g., -activated mucositis) that involves the direct mucoadministration of an active agent that is antifungal and antibacterial in an amount and for a duration effective to treat mucositis.

US Patent:

55077404, Apr 16, 1996

Filed:

Aug 8, 1994

Appl. No.:

8/287407

Inventors:

Francis E. O'Donnell - Chesterfield MO

International Classification:

A61B 3107

US Classification:

606 4

Abstract:

A thin, pliable mat to enhance visualization of corneal topography during rastostereography or videokeratoscopy. The mat is approximately 20 microns or less in thickness and constructed from hydrophobic material. In one preferred embodiment, the mat has a pattern etched thereon. In an alternative embodiment, a pattern is projected onto the mat. For rastostereography the pattern is a grid. For videokeratoscopy the pattern is concentric circles. The mat conforms to the surface of the cornea and the pattern is analyzed using conventional technology to determine corneal topography.

US Patent:

60801441, Jun 27, 2000

Filed:

Jul 28, 1997

Appl. No.:

8/901323

Inventors:

Francis E. O'Donnell - Town and Country MO

International Classification:

A61M 506

US Classification:

606 5

Abstract:

A method of performing photorefractive keratectomy (PRK) wherein the surface smoothness is enhanced. The present invention minimizes the ablation zone dimension including central ablation depth, reducing the need for overcorrection. The present invention reduces regression and scarring (haze) providing enhanced clinical outcomes with faster rehabilitation, greater refractive stability, and improved corneal clarity. Moreover, improved clinical outcomes are achieved by adjusting the initial corneal correction to take into account the effects of regression based upon non-linear predictive formulas which vary with the square of the slope of ablation smoothness (roughness) per micron of ablation depth.