Francisco E Silva

US Patent:

20130052244, Feb 28, 2013

Filed:

Aug 30, 2012

Appl. No.:

13/599514

Inventors:

Mark Weinreb - Woodbury NY, US
Francisco Javier Silva - Miramar FL, US

International Classification:

A61K 8/97
A61Q 19/08
A61K 8/14

US Classification:

424401, 424744, 424725

Abstract:

Provided are cosmetic compositions including a succulent plant stem cell extract and, optionally, an excipient. Also provided are methods of preparing a cosmetic composition. The methods include, for example, growing an callus to a predetermined size, preparing an extract from the callus, and mixing the extract with an excipient, thereby preparing a cosmetic composition.

US Patent:

20130071360, Mar 21, 2013

Filed:

Jun 28, 2012

Appl. No.:

13/536564

Inventors:

Francisco Silva - Miramar FL, US
Mark Weinreb - Woodbury NY, US
Amit N. Patel - Salt Lake City UT, US
David A. Bull - Salt Lake City UT, US

Assignee:

BIORESTORATIVE THERAPIES, INC. - Jupiter FL

International Classification:

A61K 35/12
C12N 5/071
C12N 5/07
A61K 35/36

US Classification:

424 937, 435325, 424574, 435 29, 435 61, 435377

Abstract:

Methods of developing and using cell lines, such as stem cell lines, for therapeutic or cosmetic use. In one embodiment the cell lines are used to treat a wide range of degenerative and metabolic disorders including, but not limited to, obesity, diabetes, hypertension, and cardiac deficiency. Also described are methods of using such cell lines to screen for compounds that play a role in regulating a variety of processes.

US Patent:

20140017789, Jan 16, 2014

Filed:

Jul 1, 2013

Appl. No.:

13/932562

Inventors:

Francisco Javier Silva - Miramar FL, US
Mark Weinreb - Woodbury NY, US
Amit N. Patel - Salt Lake City UT, US
David A. Bull - Salt Lake City UT, US

International Classification:

C12N 5/077

US Classification:

435377

Abstract:

Methods of developing and using cell lines, such as stem cell lines, for therapeutic or cosmetic use. In one embodiment the cell lines are used to treat a wide range of degenerative and metabolic disorders including, but not limited to, obesity, diabetes, hypertension, and cardiac deficiency. Also described are methods of using such cell lines to screen for compounds that play a role in regulating a variety of processes.

US Patent:

20140023622, Jan 23, 2014

Filed:

Jul 1, 2013

Appl. No.:

13/932468

Inventors:

Francisco Javier Silva - Miramar FL, US
Mark Weinreb - Woodbury NY, US
Amit N. Patel - Salt Lake City UT, US
David A. Bull - Salt Lake City UT, US

International Classification:

A61K 35/12
G01N 33/50

US Classification:

424 937, 435378, 424574, 435 34, 435 71, 435 61, 435377

Abstract:

Methods of developing and using cell lines, such as stem cell lines, for therapeutic or cosmetic use. In one embodiment the cell lines are used to treat a wide range of degenerative and metabolic disorders including, but not limited to, obesity, diabetes, hypertension, and cardiac deficiency. Also described are methods of using such cell lines to screen for compounds that play a role in regulating a variety of processes.

US Patent:

20140038177, Feb 6, 2014

Filed:

Jul 1, 2013

Appl. No.:

13/932544

Inventors:

Francisco Javier Silva - Miramar FL, US
Mark Weinreb - Woodbury NY, US
Amit N. Patel - Salt Lake City UT, US
David A. Bull - Salt Lake City UT, US

International Classification:

G01N 33/50

US Classification:

435 61, 435 29

Abstract:

Methods of developing and using cell lines, such as stem cell lines, for therapeutic or cosmetic use. In one embodiment the cell lines are used to treat a wide range of degenerative and metabolic disorders including, but not limited to, obesity, diabetes, hypertension, and cardiac deficiency. Also described are methods of using such cell lines to screen for compounds that play a role in regulating a variety of processes.

US Patent:

20150010513, Jan 8, 2015

Filed:

Apr 17, 2014

Appl. No.:

14/255595

Inventors:

- Jupiter FL, US
Francisco Javier Silva - Miramar FL, US

International Classification:

C12N 5/0775
C12N 15/85
G01N 33/50
A61K 35/28

US Classification:

424 937, 435366, 435 29, 506 10, 435 613

Abstract:

An isolated human brown adipose tissue stem cell line. In one embodiment, the isolated human brown adipose tissue stem cell line expresses the markers CD9, SSEA4, CD44, CD90, CD166, CD73, but not CD14, CD34, CD45 or STRO-1. In another embodiment, the isolated human brown adipose tissue stem cell line expresses the genes UCP1, PPARGC1A, NRF1, FOXC2, CREB1, SIRT3, and WNT5A (REFX). In still another embodiment, the isolated human brown adipose tissue stem cell line is capable of differentiating into osteoblasts, chondrocytes, and adipocytes.

US Patent:

20140212875, Jul 31, 2014

Filed:

Jan 24, 2014

Appl. No.:

14/163594

Inventors:

Francisco Javier Silva - Miramar FL, US

Assignee:

BioRestorative Therapies, Inc. - Jupiter FL

International Classification:

C12Q 1/68

US Classification:

435 611

Abstract:

A method of distinguishing a brown adipose cell from a white adipose cell. In one embodiment the method includes measuring the expression level of one or more genes in an adipose cell; comparing the measured expression levels to a control, and correlating the expression level of the one or more genes to an identity as a white adipose cell or a brown adipose cell. In one embodiment the one or more genes are selected from the genes listed in FIG. C. In another aspect the invention relates to a method of differentiating an adipose stem cell. In one embodiment the method includes inducing differentiation of an adipose stem cell in vitro; and distinguishing the differentiated stem cell. In another embodiment the inducing is performed by contacting the adipose stem cell with a brown adipose cell differentiation media.