Francisco O Villa

US Patent:

20140147481, May 29, 2014

Filed:

Jun 3, 2011

Appl. No.:

13/696583

Inventors:

William Gerwick - La Jolla CA, US
Lena Gerwick - La Jolla CA, US
Francisco Villa - La Jolla CA, US
Jennifer Smith - San Diego CA, US
David C Rowley - Wakefield RI, US

Assignee:

UNIVERSITY OF RHODE ISLAND RESEARCH FOUNDATION - Kingston RI
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

C07D 307/33
C07C 69/732
C07C 57/52
C07C 233/15
A61Q 11/00
A61K 8/49
A61K 8/37
A61K 8/42
A61K 8/14
A61K 9/127
A61K 8/69

US Classification:

424422, 424450, 435375, 514473, 514547, 514549, 514557, 514627, 549318, 560181, 560219, 562598, 564207

Abstract:

The invention provides novel compositions based on a structure designated as “Honaucin A”, including Honaucin A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used as bacterial quorumsensing inhibitors. Accordingly, in alternative embodiments the compositions of the invention are used as anti-bacterial agents.