Frank W Hobbs

US Patent:

20040087583, May 6, 2004

Filed:

Oct 30, 2003

Appl. No.:

10/697531

Inventors:

Frank Hobbs - Wilmington DE, US

International Classification:

C07D279/12
C07D265/30
C07D211/26
A61K031/54
A61K031/535
A61K031/445

US Classification:

514/227500, 514/237800, 514/252120, 514/317000, 514/523000, 514/419000, 544/059000, 544/163000, 544/339000, 546/229000, 558/396000

Abstract:

This invention relates generally to amino-thio-acrylonitriles of formula Ia or Ib: as MEK inhibitors, pharmaceutical compositions containing the same, and methods of using the same as for treatment and prevention of inflammatory disorders or as an anticancer radiosensitizing agent.

US Patent:

51515075, Sep 29, 1992

Filed:

Jun 12, 1991

Appl. No.:

7/713906

Inventors:

Frank W. Hobbs - Wilmington DE
George L. Trainor - Wilmington DE

Assignee:

E. I. Du Pont de Nemours and Company - Wilmington DE

International Classification:

C07H 100

US Classification:

536 23

Abstract:

Alkynylamino-nucleotides and labeled alkynylaminonucleotides useful, for example, as chain terminating substrates for DNA sequencing are provided along with several key intermediates and processes for their preparation. For some applications, longer, hydrophilic linkers are provided.

US Patent:

52427960, Sep 7, 1993

Filed:

Oct 22, 1991

Appl. No.:

7/780346

Inventors:

James M. Prober - Wilmington DE
Rudy J. Dam - Landenberg PA
Charles W. Robertson - Rockland DE
Frank W. Hobbs - Wilmington DE
George L. Trainor - Glen Mills PA

Assignee:

E. I. Du Pont de Nemours and Company - Wilmington DE

International Classification:

C12Q 168

US Classification:

435 6

Abstract:

A DNA sequencing system and method are described to detect the presence of radiant energy emitted from different excited reporter dye-labeled species (DNA fragments) following separation in time and/or space, and the identity of the species which emit radiant energy closely spaced in wavelength. Functions of the emitted energy are obtained which vary over the wavelengths of the closely spaced spectra in different senses and the functions ratioed, whereby the ratio is indicative of the identity of the DNA fragments. The emitting portion of the reporter-labeled DNA fragment is preferably one of a family of fluorescent dyes based on 9-carboxyethyl-6-hydroxy-3-oxo-3 H-xanthene. These xanthene dyes are covalently attached to the DNA fragments through the carboxylic acid functionality, preferably via an amide linkage. The dyes may be protected by including an alkoxy group at the 9-position.

US Patent:

56080638, Mar 4, 1997

Filed:

Mar 28, 1995

Appl. No.:

8/412409

Inventors:

Frank W. Hobbs - Wilmington DE
George L. Trainor - Glen Mills PA

Assignee:

E. I. Du Pont de Nemours and Company - Wilmington DE

International Classification:

C07F 96512
C07F 96561

US Classification:

544244

Abstract:

A DNA sequencing system and method are described to detect the presence of radiant energy emitted from different excited reporter dye-labeled species (DNA fragments) following separation in time and/or space, and the identity of the species which emit radiant energy closely spaced in wavelength. Functions of the emitted energy are obtained which vary over the wavelengths of the closely spaced spectra in different senses and the functions ratioed, whereby the ratio is indicative of the identity of the DNA fragments. The emitting portion of the reporter-labeled DNA fragment is preferably one of a family of fluorescent dyes based on 9-carboxyethyl-6-hydroxy-3 -oxo-3H-xanthene. These xanthene dyes are covalently attached to the DNA fragments through the carboxylic acid functionality, preferably via an amide linkage. The dyes may be protected by including an alkoxy group at the 9-position.

US Patent:

52625362, Nov 16, 1993

Filed:

Dec 5, 1990

Appl. No.:

7/622265

Inventors:

Frank W. Hobbs - Wilmington DE

Assignee:

E. I. Du Pont de Nemours and Company - Wilmington DE

International Classification:

C07D31102
C07D31182
C07F 924
C07F 906

US Classification:

546 25

Abstract:

Fluorescent reagents possessing an activated phosphate for the convenient covalent coupling to the 5'-hydroxyl of oligonucleotides. A class of 5'-fluorescence-tagged oligonucleptides is also disclosed.

US Patent:

50475193, Sep 10, 1991

Filed:

Jun 12, 1987

Appl. No.:

7/057565

Inventors:

Frank W. Hobbs - Wilmington DE
Anthony J. Cocuzza - Wilmington DE

Assignee:

E. I. Du Pont de Nemours and Company - Wilmington DE

International Classification:

C07H 100

US Classification:

536 23

Abstract:

Alkynylamino-nucleotides and labeled alkynylamino-nucleotides useful, for example, as chain terminating substrates for DNA sequencing are provided along with several key intermediates and processes for their preparation.

US Patent:

50268988, Jun 25, 1991

Filed:

Jan 31, 1990

Appl. No.:

7/472922

Inventors:

Frank W. Hobbs - Wilmington DE
James L. Meek - Wilmington DE

Assignee:

E. I. Du Pont de Nemours and Company - Wilmington DE

International Classification:

C07C 6976

US Classification:

560106

Abstract:

A process for regioselectively preparing phosphorylated cyclitols, in particular phosphorylated inositols such as myo-inositol 1,4,5-tris(phosphate) and muo-inositol 1,3,4,5-tetrakis(phosphate). Novel cyclitols produced by means of this process are also described.

US Patent:

54847010, Jan 16, 1996

Filed:

Jan 31, 1992

Appl. No.:

7/829857

Inventors:

Anthony J. Cocuzza - Wilmington DE
Frank W. Hobbs - Wilmington DE
Robert J. Zagursky - Wilmington DE
Neil A. Straus - North York, CA

Assignee:

E. I. Du Pont de Nemours and Company - Wilmington DE

International Classification:

C12Q 168
C12P 1934

US Classification:

435 6

Abstract:

A simplified method for isolating primer extension products and generating them in a form appropriate for electrophoresis is disclosed. The method is compatible with automated DNA sequencing procedures.