Frank E Overton

US Patent:

20030235880, Dec 25, 2003

Filed:

May 14, 2003

Appl. No.:

10/438784

Inventors:

Craig Weaver - Boulder CO, US
James Metz - Longmont CO, US
Jerry Kuner - Longmont CO, US
Frank Overton - Boulder CO, US

International Classification:

C12P023/00
C07H021/04
C12N009/04
C12N001/21
C12P021/02
C12N015/74

US Classification:

435/067000, 435/069100, 435/190000, 435/252300, 435/320100, 536/023200

Abstract:

Described herein is a novel three domain gene from Schizochytrium, denoted carotene synthase, that encodes a protein with three different enzymatic activities: phytoene dehydrogenase (PD), phytoene synthase (PS), and lycopene cyclase (LC). Also described is the isolated gene encoding the carotene synthase, homologues thereof, the enzyme encoded by such gene, biologically active portions and homologues thereof, recombinant nucleic acid molecules, microorganisms and plants that have been genetically modified to increase or decrease the action of such gene, and methods of producing carotenoids and derivatives thereof or methods of producing microorganisms and lipid products lacking pigmentation using the knowledge of the carotene synthase described herein.

US Patent:

20070253933, Nov 1, 2007

Filed:

Nov 8, 2006

Appl. No.:

11/557743

Inventors:

Craig Weaver - Boulder CO, US
James Metz - Longmont CO, US
Jerry Kuner - Longmont CO, US
Frank Overton - Boulder CO, US

Assignee:

MARTEK BIOSCIENCES CORPORATION - Columbia MD

International Classification:

C12P 1/04
A61K 39/00
C07H 21/04
C07K 14/00
C07K 16/18
C12N 1/21
C12N 15/00

US Classification:

424093400, 426061000, 435134000, 435252300, 435320100, 435069100, 530350000, 530387100, 536023700, 554008000

Abstract:

Described herein is a novel three domain gene from denoted carotene synthase, that encodes a protein with three different enzymatic activities: phytoene dehydrogenase (PD), phytoene synthase (PS), and lycopene cyclase (LC). Also described is the isolated gene encoding the carotene synthase, homologues thereof, the enzyme encoded by such gene, biologically active portions and homologues thereof, recombinant nucleic acid molecules, microorganisms and plants that have been genetically modified to increase or decrease the action of such gene, and methods of producing carotenoids and derivatives thereof or methods of producing microorganisms and lipid products lacking pigmentation using the knowledge of the carotene synthase described herein.

US Patent:

20070269869, Nov 22, 2007

Filed:

Nov 8, 2006

Appl. No.:

11/557761

Inventors:

Craig Weaver - Boulder CO, US
James Metz - Longmont CO, US
Jerry Kuner - Longmont CO, US
Frank Overton - Boulder CO, US

Assignee:

MARTEK BIOSCIENCES CORPORATION - Columbia MD

International Classification:

C12P 19/00
A01H 5/00
C12P 7/64
C11B 11/00

US Classification:

435072000, 435134000, 554175000, 800298000

Abstract:

Described herein is a novel three domain gene from , denoted carotene synthase, that encodes a protein with three different enzymatic activities: phytoene dehydrogenase (PD), phytoene synthase (PS), and lycopene cyclase (LC). Also described is the isolated gene encoding the carotene synthase, homologues thereof, the enzyme encoded by such gene, biologically active portions and homologues thereof, recombinant nucleic acid molecules, microorganisms and plants that have been genetically modified to increase or decrease the action of such gene, and methods of producing carotenoids and derivatives thereof or methods of producing microorganisms and lipid products lacking pigmentation using the knowledge of the carotene synthase described herein.

US Patent:

20070269881, Nov 22, 2007

Filed:

Nov 8, 2006

Appl. No.:

11/557783

Inventors:

Craig Weaver - Boulder CO, US
James Metz - Longmont CO, US
Jerry Kuner - Longmont CO, US
Frank Overton - Boulder CO, US

Assignee:

MARTEK BIOSCIENCES CORPORATION - Columbia MD

International Classification:

C12N 1/20
C07C 53/00

US Classification:

435252300, 554001000

Abstract:

Described herein is a novel three domain gene from , denoted carotene synthase, that encodes a protein with three different enzymatic activities: phytoene dehydrogenase (PD), phytoene synthase (PS), and lycopene cyclase (LC). Also described is the isolated gene encoding the carotene synthase, homologues thereof, the enzyme encoded by such gene, biologically active portions and homologues thereof, recombinant nucleic acid molecules, microorganisms and plants that have been genetically modified to increase or decrease the action of such gene, and methods of producing carotenoids and derivatives thereof or methods of producing microorganisms and lipid products lacking pigmentation using the knowledge of the carotene synthase described herein.