Franklin T Collins

Address:

3872 Buena Vis Dr, Loveland, CO 80538

VIN:

1NXBR32E87Z807986

Make:

TOYOTA

Model:

COROLLA

Year:

2007

US Patent:

6362319, Mar 26, 2002

Filed:

May 26, 1995

Appl. No.:

08/452229

Inventors:

Leu-Fen H. Lin - Boulder CO
Franklin D. Collins - Agoura Hills CA
Daniel H. Doherty - Boulder CO
Jack Lile - Nederland CO
Susan Bektesh - Boulder CO

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07K 14475

US Classification:

530399, 530350, 530402, 930 10

Abstract:

A novel neurotrophic factor referred to as glial derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequenced. A gene encoding GDNF has been subcloned into a vector, and the vector has been used to transform a host cell in order to produce biologically active GDNF in a recombinant DNA process.

US Patent:

7226758, Jun 5, 2007

Filed:

Sep 17, 1992

Appl. No.:

08/182183

Inventors:

Leu-Fen H. Lin - Boulder CO, US
Franklin D. Collins - Agoura Hills CA, US
Daniel H. Doherty - Boulder CO, US
Jack Lile - Nederland CO, US
Susan Bektesh - Boulder CO, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C12N 15/18
C12N 15/85
C12N 15/63
C12N 15/70

US Classification:

435 694, 435325, 43525233, 4353201, 536 2351, 536 231

Abstract:

A novel neurotrophic factor referred to as glial cell line-derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequenced. A gene encoding GDNF has been subcloned into a vector, and the vector has been used to transform a host cell in order to produce biologically active GDNF in a recombinant DNA process.

US Patent:

20020197675, Dec 26, 2002

Filed:

Nov 13, 2001

Appl. No.:

09/991119

Inventors:

Leu-Fen Lin - Boulder CO, US
Franklin Collins - Agoura Hills CA, US
Daniel Doherty - Boulder CO, US
Jack Lile - Nederland CO, US
Susan Bektesh - Boulder CO, US

Assignee:

Amgen Inc.

International Classification:

A61K038/00
C07K001/00
C07K016/00
C07K017/00
C07K014/00
C12N005/02
C12N005/00
C12N015/74
C12N015/70
C12N015/63
C12N015/09
C12N015/00
C12P021/06
C07H021/04

US Classification:

435/069100, 530/350000, 536/023500, 435/320100, 435/325000, 514/012000, 530/387100

Abstract:

A novel neurotrophic factor referred to as glial derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequenced. A gene encoding GDNF has been subcloned into a vector, and the vector has been used to transform a host cell in order to produce biologically active GDNF in a recombinant DNA process.

US Patent:

20040175795, Sep 9, 2004

Filed:

Jan 14, 2004

Appl. No.:

10/758622

Inventors:

Leu-Fen Lin - Boulder CO, US
Franklin Collins - Agoura Hills CA, US
Daniel Doherty - Boulder CO, US
Jack Lile - Nederland CO, US
Susan Bektesh - Boulder CO, US

Assignee:

Amgen Inc.

International Classification:

C07K014/475
C07H021/04

US Classification:

435/069100, 435/320100, 435/325000, 530/399000, 536/023500

Abstract:

A novel neurotrophic factor referred to as glial derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequenced. A gene encoding GDNF has been subcloned into a vector, and the vector has been used to transform a host cell in order to produce biologically active GDNF in a recombinant DNA process.

US Patent:

51418568, Aug 25, 1992

Filed:

Dec 28, 1989

Appl. No.:

7/458564

Inventors:

Franklin D. Collins - Boulder CO
Leu-Fen Lin - Boulder CO
Drzislav Mismer - Boulder CO
Christine Ko - Boulder CO

Assignee:

Synergen, Inc. - Boulder CO

International Classification:

C12P 2102
C12P 1934
C12N 1500
C12N 700
C12N 500
C12N 121
C12N 116
C12N 11815/70
C12N 1585
C07K 300
C07H 1512

US Classification:

435 691

Abstract:

A ciliary neurotrophic factor (CNTF), particularly sciatic nerve CNTF (SN-CNTF) is claimed. The SN-CNTF described herein is a single protein species and has a specific activity that increased to greater than 25,000-fold from crude extract. Amino acid data for this SN-CNTF is also provided. In addition, methods for using this data for providing SN-CNTF probes and for screening cDNA and genomic libraries are also provided. Recombinant-DNA methods for the production of SN-CNTF are described. Nucleic acid sequences encoding rabbit and human CNTF are provided. A recombinant expression system is provided for producing biologically active CNTF.

US Patent:

50119141, Apr 30, 1991

Filed:

Jan 5, 1989

Appl. No.:

7/293851

Inventors:

Franklin D. Collins - Boulder CO
Leu-Fen Lin - Golden CO

International Classification:

C07K 314
C07K 318
C07K 324
C07K 328

US Classification:

530399

Abstract:

A ciliary neurotrophic factor (CNTF), particularly sciatic nerve CNTF (SN-CNFT) is claimed. The SN-CNTF described herein is a single protein species and has a specific activity that increased to greater than 25,000-fold from crude extract. The purification is carried out by lowering the pH of the crude nerve extract preparation to form a precipitate which is removed and discarded; raising the pH to about 6. 3 followed by ammonium sulfate fractionation; chromatofocusing a solution containing a second precipitate obtained from the 30% to 60% ammonium sulfate containing solution; subjecting the fractions obtained by chromatofocusing to sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis (PAGE); and performing reversed-phase high-performance liquid chromatography (HPLC) on the SDS-PAGE eluate. Amino acid data for this SN-CNTF is also provided. In addition, methods for using this data for providing SN-CNTF probes and for screening cDNA and genomic libraries are also provided.

US Patent:

49979299, Mar 5, 1991

Filed:

Sep 8, 1989

Appl. No.:

7/404533

Inventors:

Franklin D. Collins - Boulder CO
Leu-Fen Lin - Boulder CO

Assignee:

Synergen, Inc. - Boulder CO

International Classification:

C12P 2100
C12N 1500
C07H 1512

US Classification:

536 27

Abstract:

A ciliary neurotrophic factor (CNTF), particularly sciatic nerve CNTF(SN-CNFT) is claimed. The SN-CNTF described herein is a single protein species and has a specific activity that increased to greater than 25,000-fold from crude extract. Amino acid data for this SN-CNTF is also provided. In addition, methods for using this data for providing SN-CNTF probes and for screening cDNA and genomic libraries are also provided. Recombinant-DNA methods for the production of SN-CNTF are described. Nucleic acid sequences encoding rabbit and human CNTF are provided. A recombinant expression system is provided for producing biologically active CNTF.

US Patent:

60155728, Jan 18, 2000

Filed:

May 30, 1995

Appl. No.:

8/453176

Inventors:

Leu-Fen H. Lin - Boulder CO
Franklin D. Collins - Agoura Hills CA
Daniel H. Doherty - Boulder CO
Jack Lile - Nederland CO
Susan Bektesh - Boulder CO

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61F 200
A61K 922
C12N 1104

US Classification:

424424

Abstract:

A novel neurotrophic factor referred to as glial cell line-derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequenced. A gene encoding GDNF has been subcloned into a vector, and the vector has been used to transform a host cell in order to produce biologically active GDNF in a recombinant DNA process. An implantable device containing recombinant GDNF secreting cells encapsulated in a semipermeable membrane may be used to treat nerve damage in patients suffering from disorders such as Parkinson's disease.