Fred T Bizzarro

US Patent:

6489485, Dec 3, 2002

Filed:

May 1, 2001

Appl. No.:

09/846820

Inventors:

Fred Thomas Bizzarro - Colonia NJ
Nancy-Ellen Haynes - Cranford NJ
Ramakanth Sarabu - Cedar Grove NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D27704

US Classification:

548195

Abstract:

Para-alkyl, aryl, cycloheteroalkyl or heteroaryl [carbonyl or sulfonyl] amino substituted phenyl amides active as glucokinase activators to increase insulin secretion which makes them useful for treating type II diabetes.

US Patent:

6528543, Mar 4, 2003

Filed:

Mar 21, 2000

Appl. No.:

09/532506

Inventors:

Fred Thomas Bizzarro - Colonia NJ
Wendy Lea Corbett - Randolph NJ
Antonio Focella - Wayne NJ
Joseph Francis Grippo - Stirling NJ
Nancy-Ellen Haynes - Cranford NJ
George William Holland - North Caldwell NJ
Robert Francis Kester - Hackensack NJ
Paige Erin Mahaney - Montclair NJ
Ramakanth Sarabu - Cedar Grove NJ

Assignee:

Hoffman-La Roche Inc. - Nutley NJ

International Classification:

A61K 3117

US Classification:

514594, 514522, 514530, 514542, 514595, 558413, 558417, 560 9, 560 13, 564 47, 564 56

Abstract:

Glucokinase activating compounds of the formula wherein R and R are independently hydrogen, halo, amino, nitro, cyano, sulfonamido, lower alkyl, perfluoro-lower alkyl, lower alkyl thio, perfluoro-lower alkyl thio, lower alkyl sulfonyl, or perfluoro-lower alkyl sulfonyl; R is cycloalkyl having from 3 to 7 carbon atoms or lower alkyl having from 2 to 4 carbon atoms; R is hydrogen, lower alkyl, lower alkenyl, hydroxy lower alkyl, halo lower alkyl, R and R are hydrogen or lower alkyl; and n is 0, 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof.

US Patent:

6610846, Aug 26, 2003

Filed:

Sep 28, 2000

Appl. No.:

09/675781

Inventors:

Fred Thomas Bizzarro - Colonia NJ
Wendy Lea Corbett - Randolph NJ
Joseph Francis Grippo - Stirling NJ
Nancy-Ellen Haynes - Cranford NJ
George William Holland - Houston TX
Robert Francis Kester - Verona NJ
Paige Erin Mahaney - Montclair NJ
Ramakanth Sarabu - Pine Brook NJ

Assignee:

Hoffman-La Roche Inc. - Nutley NJ

International Classification:

C07D23724

US Classification:

544182, 544211, 544224, 544238, 544329, 544336

Abstract:

2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.

US Patent:

6951945, Oct 4, 2005

Filed:

Jul 9, 2003

Appl. No.:

10/616359

Inventors:

Fred Thomas Bizzarro - Colonia NJ, US
Wendy Lea Corbett - Randolph NJ, US
Joseph Francis Grippo - Stirling NJ, US
Nancy-Ellen Haynes - Cranford NJ, US
George William Holland - Houston TX, US
Robert Francis Kester - Verona NJ, US
Paige Erin Mahaney - Montclair NJ, US
Ramakanth Sarabu - Pine Brook NJ, US

Assignee:

Hoffman-La Roche Inc. - Nutley NJ

International Classification:

C07D285/06
C07D285/12
C07D277/04
C07D275/02

US Classification:

548127, 548128, 548134, 548139, 548195, 548214

Abstract:

2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.

US Patent:

7223868, May 29, 2007

Filed:

Apr 4, 2005

Appl. No.:

11/098717

Inventors:

Fred Thomas Bizzarro - Colonia NJ, US
Wendy Lea Corbett - Randolph NJ, US
Joseph Francis Grippo - Stirling NJ, US
Nancy-Ellen Haynes - Cranford NJ, US
George William Holland - Houston TX, US
Robert Francis Kester - Verona NJ, US
Paige Erin Mahaney - Montclair NJ, US
Ramakanth Sarabu - Pine Brook NJ, US

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D 213/75
C07D 213/84

US Classification:

546289, 546297, 546309, 546310

Abstract:

2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.

US Patent:

20030060625, Mar 27, 2003

Filed:

Sep 26, 2002

Appl. No.:

10/255440

Inventors:

Fred Bizzarro - Colonia NJ, US
Nancy-Ellen Haynes - Cranford NJ, US
Ramakanth Sarabu - Pinebrook NJ, US

International Classification:

C07D279/12
C07C311/36
C07D277/04
C07D295/22

US Classification:

544/059000, 544/158000, 544/170000, 544/399000, 546/229000, 548/204000, 548/236000, 548/335500, 564/152000

Abstract:

Para-alkyl, aryl, cycloheteroalkyl or heteroaryl [carbonyl or sulfonyl] amino substituted phenyl amides active as glucokinase activators to increase insulin secretion which makes them useful for treating type II diabetes.

US Patent:

20070203207, Aug 30, 2007

Filed:

Apr 23, 2007

Appl. No.:

11/789105

Inventors:

Fred Bizzarro - Colonia NJ, US
Wendy Corbett - Randolph NJ, US
Joseph Grippo - Stirling NJ, US
Nancy-Ellen Haynes - Cranford NJ, US
George Holland - Houston TX, US
Robert Kester - Verona NJ, US
Paige Mahaney - Montclair NJ, US
Ramakanth Sarabu - Pine Brook NJ, US

International Classification:

A61K 31/425
C07C 211/00
C07C 211/01
C07C 311/00
C07D 277/00

US Classification:

514365000, 548199000, 562837000, 564001000, 564366000

Abstract:

2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.

US Patent:

63200503, Nov 20, 2001

Filed:

Mar 15, 2000

Appl. No.:

9/526143

Inventors:

Fred Thomas Bizzarro - Colonia NJ
Wendy Lea Corbett - Randolph NJ
Joseph Francis Grippo - Stirling NJ
Nancy-Ellen Haynes - Cranford NJ
George William Holland - North Caldwell NJ
Robert Francis Kester - Hackensack NJ
Ramakanth Sarabu - Cedar Grove NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D27738
C07D21326
C07D23942

US Classification:

544332

Abstract:

2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.