Frederick F Becker

US Patent:

6362200, Mar 26, 2002

Filed:

Aug 8, 2000

Appl. No.:

09/634102

Inventors:

Frederick F. Becker - Houston TX
Bimal K. Banik - Missouri City TX

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C07D29518

US Classification:

514319, 546195

Abstract:

Dibenzofluorene derivatives having a formula selected from the group consisting of and salts thereof have antitumor activity. At least one of R -R in formula (I) or R -R in formula (II) is âR Z. R is a substituted or unsubstituted amino or amido group having from 1-12 carbon atoms, and Z is a substituted or unsubstituted heterocyclic group having from 1-12 carbon atoms. The remainder of R -R in formula (I) or R -R in formula (II) are independently selected from the group consisting of hydrogen, hydroxyl, halogen, nitro, substituted or unsubstituted amino or amido groups having from 1-12 carbon atoms, and alkyl groups having 1-12 carbon atoms.

US Patent:

6437551, Aug 20, 2002

Filed:

Nov 1, 2000

Appl. No.:

09/704355

Inventors:

Peter Krulevitch - Pleasanton CA
Harold D. Ackler - Sunnyvale CA
Frederick Becker - Houston TX
Bernhard E. Boser - Berkeley CA
Adam B. Eldredge - Austin TX
Christopher K. Fuller - Livermore CA
Peter R. C. Gascoyne - Bellaire TX
Julie K. Hamilton - Tracy CA
Stefan P. Swierkowski - Livermore CA
Xiao-Bo Wang - San Diego CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N 2700

US Classification:

324 711, 324649, 436518

Abstract:

A microfabricated instrument for detecting and identifying cells and other particles based on alternating current (AC) impedance measurements. The microfabricated AC impedance sensor includes two critical elements: 1) a microfluidic chip, preferably of glass substrates, having at least one microchannel therein and with electrodes patterned on both substrates, and 2) electrical circuits that connect to the electrodes on the microfluidic chip and detect signals associated with particles traveling down the microchannels. These circuits enable multiple AC impedance measurements of individual particles at high throughput rates with sufficient resolution to identify different particle and cell types as appropriate for environmental detection and clinical diagnostic applications.

US Patent:

6479662, Nov 12, 2002

Filed:

Jan 14, 2002

Appl. No.:

10/047301

Inventors:

Frederick F. Becker - Houston TX
Bimal K. Banik - Missouri City TX

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C07D29518

US Classification:

546195

Abstract:

Dibenzofluorene derivatives having a formula selected from the group consisting of and salts thereof have antitumor activity. At least one of R -R in formula (I) or R -R in formula (II) is âR Z. R is a substituted or unsubstituted amino or amido group having from 1-12 carbon atoms, and Z is a substituted or unsubstituted heterocyclic group having from 1-12 carbon atoms. The remainder of R -R in formula (I) or R -R in formula (II) are independently selected from the group consisting of hydrogen, hydroxyl, halogen, nitro, substituted or unsubstituted amino or amido groups having from 1-12 carbon atoms, and alkyl groups having 1-12 carbon atoms.

US Patent:

6641708, Nov 4, 2003

Filed:

Aug 23, 1999

Appl. No.:

09/378874

Inventors:

Frederick F. Becker - Houston TX
Peter R. C. Gascoyne - Belaire TX
Ying Huang - San Diego CA
Xiao-Bo Wang - San Diego CA
Jun Yang - Houston TX

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

G01N 2726

US Classification:

204547, 204643

Abstract:

Methods and apparatus for discriminating matter in a chamber having an inlet port and an outlet port utilizing dielectrophoresis and field flow fractionation. A carrier medium is introduced into the inlet port and is directed from the inlet port to the outlet port according to a velocity profile. A programmed voltage signal is applied to an electrode element coupled to the chamber to form a dielectrophoretic force on the matter. The dielectrophoretic force is balanced with a gravitational force to displace the matter to positions within said velocity profile in the carrier medium to discriminate the matter. A chamber having a top and bottom outlet port may be utilized to withdraw a first portion of a carrier medium from the top outlet port at a first, controllable fluid flow rate and to withdraw a second portion of the carrier medium from the bottom outlet port at a second, controllable fluid flow rate.

US Patent:

6703819, Mar 9, 2004

Filed:

Dec 3, 2001

Appl. No.:

10/005373

Inventors:

Peter Gascoyne - Bellaire TX
Tom Anderson - Houston TX
Jody Vykoukal - Houston TX
Frederick Becker - Houston TX

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

G01N 2700

US Classification:

324 714

Abstract:

Apparatuses and methods for analyzing particles using an impedance sensor. A flow-through impedance sensor may use two in-line electrodes driven in counter phase. A common sensor electrode may be used to, for example, detect impedance and determine trajectories through the sensor area. The sensor may be used in a wide variety of applications, including but not limited to use with microfluidic devices for determining particle characteristics such as position, velocity, size, and concentration as well as detection of bacterial spores and other biological agents of potential use in warfare and bio-terrorism.

US Patent:

6790330, Sep 14, 2004

Filed:

Jun 14, 2001

Appl. No.:

09/883110

Inventors:

Peter Gascoyne - Bellaire TX
Jody V. Vykoukal - Houston TX
Frederick F. Becker - Houston TX

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

G01N 27447

US Classification:

204547, 204643

Abstract:

Systems, apparatuses and methods for cell isolation and analysis. Cells are introduced into a dielectrophoretic prefilter including one or more trapping electrodes configured to trap at least a portion of the cells with a dielectrophoretic force. The cells trapped from the prefilter are directed into a dielectrophoretic field-flow fractionation separator coupled to the prefilter. The cells are discriminated by balancing a dielectrophoretic force (and optionally a magnetophoretic force) with a gravitational force to displace the cells to positions within a velocity profile in the separator. At least a portion of the cells are trapped as a function of the cells time of emergence from the separator with two or more spiral electrode segments coupled to the separator.

US Patent:

6866762, Mar 15, 2005

Filed:

Dec 20, 2001

Appl. No.:

10/028945

Inventors:

Peter Gascoyne - Bellaire TX, US
Jon Schwartz - Sugar Land TX, US
Jody V. Vykoukal - Houston TX, US
Frederick F. Becker - Houston TX, US

Assignee:

Board of Regents, University of Texas System - Austin TX

International Classification:

G01N027/447
G01N027/453

US Classification:

204547, 204643

Abstract:

A dielectric gate and related systems and methods for controlling fluid flow. A dielectric gate includes one or more electrodes coupled between an inlet fluid pathway and an outlet fluid pathway. The electrodes are configured to draw fluid from the inlet fluid pathway to the outlet fluid pathway in a precise manner by using dielectric forces arising from electrical signals applied to the electrodes.

US Patent:

6893547, May 17, 2005

Filed:

Jun 14, 2001

Appl. No.:

09/883109

Inventors:

Peter Gascoyne - Bellaire TX, US
Jody V. Vykoukal - Houston TX, US
Jon Schwartz - Sugar Land TX, US
Frederick F. Becker - Houston TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

G01N027/447
G01N027/453

US Classification:

204547, 204643

Abstract:

Methods and apparatuses for metered injection of a fluid packet. A vessel containing a fluid is pressurized to a pressure less than or equal to a hold-off pressure. The fluid is subjected to an extraction force to form the fluid packet and extract the fluid packet from the vessel onto a surface.