Gang Chen

US Patent:

6459487, Oct 1, 2002

Filed:

Sep 4, 2001

Appl. No.:

09/944126

Inventors:

Gang Paul Chen - Monterey Park CA 91754
Avishay Eyal - Pasedena CA 91106
Anthony S. Kewitsch - Santa Monica CA 90402
Victor Leyva - Pasedena CA 91104
George A. Rakuljic - Santa Monica CA 90402

International Classification:

G01B 902

US Classification:

356491, 356492

Abstract:

Optical components, particularly microoptic glass components used in synthesizing birefringence in filter systems based on polarization interferometer techniques, are fabricated using systems and methods which provide accurate frequency periodicity measurements. These measurements are derived from differential delays induced by in-process glass elements between beam components in a polarization interferometer unit and from progressive wavelength scanning across a wavelength band of interest. The consequent sinusoidal output variation has peak to peak spacings which are measured to provide frequency periodicity values from which precise length corrections for the optical elements can be calculated.

US Patent:

6546167, Apr 8, 2003

Filed:

Dec 11, 2001

Appl. No.:

10/014324

Inventors:

Gang Chen - Walnut CA
Stephanus J. Spammer - Painted Post NY

Assignee:

Corning Incorporated - Corning NY

International Classification:

G02B 628

US Classification:

385 24, 385 37, 385 46, 359130

Abstract:

One aspect of the invention is an optical add/drop multiplexer. The optical add/drop multiplexer includes a first optical circulator, the first circulator includes a first port, a second port, and a third port. The optical add/drop multiplexer also includes a first tunable grating coupled to the first port and a second tunable grating coupled to the first grating. The optical add/drop multiplexer further includes a second optical circulator, the second optical circulator includes a fourth port, coupled to the second grating; a fifth port, and a sixth port. Wherein the first tunable grating is a fiber Bragg grating and wherein the second tunable grating is a fiber Bragg grating.

US Patent:

6846113, Jan 25, 2005

Filed:

May 15, 2003

Appl. No.:

10/438411

Inventors:

Xian-Li Yeh - Walnut CA, US
Gang Paul Chen - Walnut CA, US

International Classification:

H04N 595

US Classification:

385 88, 385 90, 385 91

Abstract:

Locally heated low temperature solder glass is used to permanently fix an optical fiber with sub-micron precision to a glass ceramic submount inside a high power pump laser module. The fiber is manipulated into a predetermined alignment while the solder glass is still molten and the solder glass is then cooled to its solidified state. The predetermined alignment may include an offset to compensate for subsequent thermally related dimensional changes as the solder glass cools and solidifies. If necessary, the solder glass can be remelted and the fiber realigned with a different offset if the first alignment attempt is less than optimal. This alignment process has been demonstrated to provide reliable and efficient coupling of an optical fiber to a high power pump laser within very tight tolerances. A similar process can also be applied to other micro-optics assemblies where high precision, high reliability fiber fixing is required.

US Patent:

7829063, Nov 9, 2010

Filed:

Apr 7, 2008

Appl. No.:

12/099135

Inventors:

Hartmuth C. Kolb - Playa Del Rey CA, US
Joseph C. Walsh - Pacific Palisades CA, US
Dhanalakshmi Kasi - Los Angeles CA, US
Vani P. Mocharla - Los Angeles CA, US
Bing Wang - San Jose CA, US
Umesh B. Gangadharmath - Los Angeles CA, US
Brian A. Duclos - Kalamazoo MI, US
Kai Chen - Los Angeles CA, US
Wei Zhang - Los Angeles CA, US
Gang Chen - Los Angeles CA, US
Henry Clifton Padgett - Hermosa Beach CA, US
Farhad Karimi - Canton MA, US
Peter J. H. Scott - Marina-del-Ray CA, US
Zhiyong Gao - Los Angeles CA, US
Qianwa Liang - Hacienda Heights CA, US
Thomas Lee Collier - Perkasie PA, US
Tieming Zhao - Los Angeles CA, US
Chunfang Xia - Los Angeles CA, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

A61K 51/00
C07D 343/00

US Classification:

424 111, 549 32

Abstract:

The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.

US Patent:

8293206, Oct 23, 2012

Filed:

Jun 1, 2009

Appl. No.:

12/455346

Inventors:

Hartmuth C. Kolb - Playa Del Rey CA, US
Joseph C. Walsh - Pacific Palisades CA, US
Kai Chen - Rockville MD, US
Dhanalakshmi Kasi - Los Angeles CA, US
Umesh B. Gangadharmath - Los Angeles CA, US
Peter J. H. Scott - Ypsilanti MI, US
Gang Chen - Los Angeles CA, US
Vani P. Mocharla - Los Angeles CA, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

A61M 36/14
A61K 39/00

US Classification:

424 169, 4241811

Abstract:

The present disclosure provides methods for treating cancer in a patient in need of such treatment, the method includes prequalifying a patient's therapeutic treatment by performing a molecular imaging procedure to the patient using a labeled biomarker specific for a cancer target at the tumor site; and administering a therapeutic effective amount of a compound comprising a targeting agent linked to a chemotherapeutic or a targeting agent linked to an antibody. Embodiments of the present invention also include compounds and compositions for using such methods.

US Patent:

8318132, Nov 27, 2012

Filed:

Feb 17, 2009

Appl. No.:

12/372717

Inventors:

Hartmuth C. Kolb - Playa Del Rey CA, US
Joseph C. Walsh - Pacific Palisades CA, US
Wei Zhang - Los Angeles CA, US
Peter J. H. Scott - Marina-del-Rey CA, US
Kai Chen - Los Angeles CA, US
Vani P. Mocharla - Los Angeles CA, US
Dhanalakshmi Kasi - Los Angeles CA, US
Gang Chen - Los Angeles CA, US
Eric Wang - San Diego CA, US
Anjana Sinha - San Diego CA, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

A61K 51/00
A61M 36/14

US Classification:

424 111, 424 189, 424 185, 424 181, 424 165, 424 91

Abstract:

Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease.

US Patent:

8354092, Jan 15, 2013

Filed:

Aug 25, 2010

Appl. No.:

12/862955

Inventors:

Hartmuth C. Kolb - Playa Del Rey CA, US
Joseph C. Walsh - Pacific Palisades CA, US
Dhanalakshmi Kasi - Los Angeles CA, US
Vani P. Mocharla - Los Angeles CA, US
Bing Wang - San Jose CA, US
Umesh B. Gangadharmath - Los Angeles CA, US
Brian A. Duclos - Kalamazoo MI, US
Kai Chen - Rockville MD, US
Wei Zhang - Norwood MA, US
Gang Chen - Los Angeles CA, US
Henry Clifton Padgett - Hermosa Beach CA, US
Farhad Karimi - Mansfield MA, US
Peter J. H. Scott - Ypsilanti MI, US
Zhiyong Gao - Wynnewood PA, US
Qianwa Liang - Hacienda Heights CA, US
Thomas Lee Collier - Perkasie PA, US
Tieming Zhao - Los Angeles CA, US
Chunfang Xia - Los Angeles CA, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

A61K 51/00
C07D 249/00
C07D 343/00

US Classification:

424 153, 514359, 514449, 514461, 530330, 548255, 549429

Abstract:

The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.

US Patent:

8420052, Apr 16, 2013

Filed:

Jul 24, 2009

Appl. No.:

12/509259

Inventors:

Hartmuth C. Kolb - Playa Del Rey CA, US
Joseph C. Walsh - Pacific Palisades CA, US
Wei Zhang - Los Angeles CA, US
Umesh B. Gangadharmath - Los Angeles CA, US
Dhanalakshmi Kasi - Los Angeles CA, US
Kai Chen - Rockville MD, US
Anjana Sinha - San Diego CA, US
Eric Wang - San Diego CA, US
Gang Chen - Los Angeles CA, US
Peter J. H. Scott - Ypsilanti MI, US
Henry Clifton Padgett - Hermosa Beach CA, US
Qianwa Liang - Hacienda Heights CA, US
Zhiyong Gao - Wynnewood PA, US
Tieming Zhao - Los Angeles CA, US
Chunfang Xia - Los Angeles CA, US
Vani P. Mocharla - Los Angeles CA, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

A61K 51/00
A61M 36/14

US Classification:

424 189, 424 111, 424 165, 424 181, 424 185

Abstract:

Provided herein are compounds and compositions which comprise the formulae as disclosed herein, wherein the compound is an amyloid binding compound. An amyloid binding compound according to the invention may be administered to a patient in amounts suitable for in vivo imaging of amyloid deposits, and distinguish between neurological tissue with amyloid deposits and normal neurological tissue. Amyloid probes of the invention may be used to detect and quantitate amyloid deposits in diseases including, for example, Down's syndrome, familial Alzheimer's Disease. In another embodiment, the compounds may be used in the treatment or prophylaxis of neurodegenerative disorders. Also provided herein are methods of allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing a neurodegenerative disease.